Search results for "45"

Repeated exposure of fluazinam fungicides affects gene expression profiles yet carries no costs on a nontarget pest

2021

Fungicides are used to control pathogenic fungi of crop species, but they have also been shown to alter behavioral, life history and fitness related traits of non-target insects. Here, we tested the fungicide effects on feeding behavior, survival and physiology of the non-target pest insect, the Colorado potato beetle (Leptinotarsa decemlineata). Feeding behavior was studied by a choice test of adult beetles, which were allowed to choose between a control and a fungicide (fluazinam) treated potato leaf. Larval survival was recorded after 24-hour and 72-hour exposure to control and fungicide-treated leaves with two different concentrations. The adults did not show fungicide avoidance behavio…

Anisotropic elliptic equations with gradient-dependent lower order terms and L^1 data

2023

<abstract><p>We prove the existence of a weak solution for a general class of Dirichlet anisotropic elliptic problems such as $ \mathcal Au+\Phi(x, u, \nabla u) = \mathfrak{B}u+f $ in $ \Omega $, where $ \Omega $ is a bounded open subset of $ \mathbb R^N $ and $ f\in L^1(\Omega) $ is arbitrary. The principal part is a divergence-form nonlinear anisotropic operator $ \mathcal A $, the prototype of which is $ \mathcal A u = -\sum_{j = 1}^N \partial_j(|\partial_j u|^{p_j-2}\partial_j u) $ with $ p_j > 1 $ for all $ 1\leq j\leq N $ and $ \sum_{j = 1}^N (1/p_j) > 1 $. As a novelty in this paper, our lower order terms involve a new class of operators $ \mathfrak B $ such…

Monohydroxylated fatty acid substrate specificity of human leukocyte 5-lipoxygenase and ω-hydroxylase

1988

Various monohydroxylated fatty acids were synthesized from eicosapolyenoic acids, namely arachidonic (20:4 omega-6), timnodonic (20:5 omega-3), dihomogammalinolenic (20:3 omega-6) and mead (20:3 omega-9) acids. 12-Hydroxy derivatives, as well as 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT), were produced with platelets as the enzyme source, and 15-hydroxy derivatives were produced by soya bean lipoxygenase treatment. Each monohydroxylated fatty acid was incubated with human leukocytes in the presence or absence of the calcium ionophore A23187, and dihydroxylated products were analysed by h.p.l.c. 12-Hydroxy derivatives of 20:4 omega-6, 20:5 omega-3 and 20:3 omega-9 were similarly oxygenat…

Fame. Espressioni, esperienze, esperimenti nel Moderno

2008

Dire la fame. "Se questo è un uomo" e altre esperienze (meta)linguistiche del Moderno

2009

Zvaigžņotā Debess: 2018, Pavasaris (239)

2018

Contents: “ZVAIGŽŅOTĀ DEBESS” FORTY YEARS AGO: A.Balklavs. Some Considerations about Communication with Extraterrestrial Civilizations (abridged) ; I.Rabinovičs. Does the Moon Affect Living Nature? (abridged) ; DEVELOPMENTS in SCIENCE: K.Schwartz. Brown Dwarfs ; DISCOVERIES: I.Pundure. Odd Movements of Star Reveal Lonely Black Hole in Globular Star Cluster ; I.Pundure. Gaia Enables Viewing Evolution of Orion Constellation over Coming 450 000 Years ; J.Kuzmanis. A Guest from Another Stars ; SPACE RESEARCH and EXPLORATION: J.Jaunbergs. To Catch the Galactic Visitor `Oumuamua ; J.Jaunbergs. Invisible Connections of Dione ; LATVIAN SCIENTISTS: The List of Popular Science Papers (1958-2016) by P…

Unexpected DNA damage caused by polycyclic aromatic hydrocarbons under standard laboratory conditions

2007

Abstract The genotoxicity of 15 polycyclic aromatic hydrocarbons was determined with the alkaline version of the comet assay employing V79 lung fibroblasts of the Chinese hamster as target cells. These cells lack the enzymes necessary to convert PAHs to DNA-binding metabolites. Surprisingly, 11 PAHs, i.e., benzo[ a ]pyrene (BaP), benz[ a ]anthracene, 7,12-dimethylbenz[ a ]anthracene, 3-methylcholanthrene, fluoranthene, anthanthrene, 11 H -benzo[ b ]fluorene, dibenz[ a,h ]anthracene, pyrene, benzo[ ghi ]perylene and benzo[ e ]pyrene caused DNA strand breaks even without external metabolic activation, while naphthalene, anthracene, phenanthrene and naphthacene were inactive. When the comet as…

Nimbolide inhibits 2D and 3D prostate cancer cells migration, affects microtubules and angiogenesis and suppresses B-RAF/p.ERK-mediated in vivo tumor…

2021

Abstract Background Prostate cancer (PCa) is the most prominent malignancy among men worldwide. PCa cells have a high tendency to metastasize to various distant organs, and this activity is the main cause of PCa mortality. Nimbolide is a promising phytochemical constituent of neem Azadirachta indica (Meliaceae). Previous studies showed that nimbolide exhibited potent anticancer activity however, its role against PCa tumorigenesis has not been fully elucidated. Purpose Our work aims to explore the role of nimbolide in regulating the essential tumor-associated processes involved in the metastatic cascade in PCa cells. Study design Cytotoxicity assay, wound healing and spheroid invasion assays…

Verb inflection in Ancient Greek and Sanskrit and auxiliation patterns in French and Italian. Forms, functions, system

2009

This paper deals with the complex interaction between form and function in the verb morphosyntax of four Indo-European languages (French, Italian, Ancient Greek and Sanskrit). Beyond the difference in form, auxiliation patterns in French and Italian, and verb inflections in Ancient Greek and Sanskrit correlate, thanks to the agreement for number and person, to the expression of the relationship with the Subject. The different auxiliation patterns (sum and habeo) and the different inflections (middle and active) correlate to different properties of the Subject. In particular, these forms depend on the syntactic opposition between middle and non-middle. The ways of this dependency are regulat…

Genetic signature consistent with selection against the CYP3A4*1B allele in non-African populations.

2005

Cytochrome P450 3A enzymes (CYP3A) play a major role in the metabolism of steroid hormones, drugs and other chemicals, including many carcinogens. The individually variable CYP3A expression, which remains mostly unexplained, has been suggested to affect clinical phenotypes. We investigated the CYP3A locus in five ethnic groups. The degree of linkage disequilibrium (LD) differed among ethnic groups, but the most common alleles of the conserved LD regions were remarkably similar. Non-African haplotypes are few; for example, only four haplotypes account for 80% of common European Caucasian alleles. Large LD blocks of high frequencies were suggestive of selection. Accordingly, European Caucasia…