Search results for "46"
showing 10 items of 1176 documents
Treatment approaches to patients with multiple sclerosis and coexisting autoimmune disorders.
2021
The past decades have yielded major therapeutic advances in many autoimmune conditions – such as multiple sclerosis (MS) – and thus ushered in a new era of more targeted and increasingly potent immunotherapies. Yet this growing arsenal of therapeutic immune interventions has also rendered therapy much more challenging for the attending physician, especially when treating patients with more than one autoimmune condition. Importantly, some therapeutic strategies are either approved for several autoimmune disorders or may be repurposed for other conditions, therefore opening new curative possibilities in related fields. In this article, we especially focus on frequent and therapeutically rele…
Comparable efficacy and safety of dimethyl fumarate and teriflunomide treatment in Relapsing-Remitting Multiple Sclerosis: an Italian real-word multi…
2018
BACKGROUND: The aim of the study was to evaluate the achievement of 'no evidence of disease activity' (NEDA) over a 12-month period in a large multicenter population with relapsing remitting multiple sclerosis (RRMS) treated with delayed-release dimethyl fumarate (DMF) and teriflunomide (TRF) using a propensity-score adjustment. METHODS: A time-to-event method was used to determine the percentages of patients with RRMS (pwRRMS) in both groups achieving NEDA 3 (no relapses, no 12-week confirmed disability progression, and no new T2/gadolinium-enhancing brain lesions). We described the safety profile of the investigated drugs. RESULTS: Of the 587 pwRRMS treated with DMF and the 316 pwRRMS tre…
Brief an Johann Gottfried Herder
1797
Shape identification in inverse medium scattering problems with a single far-field pattern
2016
Consider time-harmonic acoustic scattering from a bounded penetrable obstacle $D\subset {\mathbb R}^N$ embedded in a homogeneous background medium. The index of refraction characterizing the material inside $D$ is supposed to be Holder continuous near the corners. If $D\subset {\mathbb R}^2$ is a convex polygon, we prove that its shape and location can be uniquely determined by the far-field pattern incited by a single incident wave at a fixed frequency. In dimensions $N \geq 3$, the uniqueness applies to penetrable scatterers of rectangular type with additional assumptions on the smoothness of the contrast. Our arguments are motivated by recent studies on the absence of nonscattering waven…
Difficiles nugae: costrutti impersonali riflessivi e non riflessivi
2009
Excessive Daytime Sleepiness in Obstructive Sleep Apnea Patients Treated With Continuous Positive Airway Pressure: Data From the European Sleep Apnea…
2021
Excessive daytime sleepiness (EDS) is a symptom of obstructive sleep apnea (OSA) that resolves under treatment with continuous positive airway pressure (CPAP). In some patients, sleepiness persists despite CPAP treatment. We retrospectively analyzed data on subjective residual EDS, assessed as an Epworth Sleepiness Scale score (ESS) >10, in patients from the European Sleep Apnea Database (n = 4,853, mean age +/- SD 54.8 +/- 11.8 years, 26.1% females), at baseline and at the first visit (median follow-up: 5 months, interquartile range 3-13). An ESS > 10 occurred in 56% of patients at baseline and in 28.2% of patients at follow-up. Residual EDS was analyzed in 2,190 patients (age: 55.1 +/- 12…
Art. 2462 c.c.
2010
La pubblicazione ha ad oggetto l'analisi dell'art. 2462 c.c., inerente il regime della responsabilità dei soci della s.r.l.Il commento si sofferma sulle innovazioni legate alla riforma del diritto societario del 2003, sottolineandone le ricadute sulla nozione ed i connotati tipologici della società a responsabilità limitata. Particolare attenzione è dedicata alla disciplina della responsabilità dell'unico socio ed al regime giuridico delle operazioni compiute anteriormente all'iscrizione della s.r.l. nel registro delle imprese.
The close classical T Tauri binary V4046 Sgr: Complex magnetic fields & distributed mass accretion
2011
We report here the first results of a multi-wavelength campaign focussing on magnetospheric accretion processes within the close binary system V4046 Sgr, hosting two partly-convective classical T Tauri stars of masses ~0.9 Msun and age ~12 Myr. In this paper, we present time-resolved spectropolarimetric observations collected in 2009 September with ESPaDOnS at the Canada-France-Hawaii Telescope (CFHT) and covering a full span of 7d or ~2.5 orbital/rotational cycles of V4046 Sgr. Small circularly polarised Zeeman signatures are detected in the photospheric absorption lines but not in the accretion-powered emission lines of V4046 Sgr, thereby demonstrating that both system components host lar…
Regular solutions for nonlinear elliptic equations, with convective terms, in Orlicz spaces
2022
We establish some existence and regularity results to the Dirichlet problem, for a class of quasilinear elliptic equations involving a partial differential operator, depending on the gradient of the solution. Our results are formulated in the Orlicz-Sobolev spaces and under general growth conditions on the convection term. The sub- and supersolutions method is a key tool in the proof of the existence results.
Synchronizing Two Superconducting Qubits through a Dissipating Resonator
2021
A system consisting of two qubits and a resonator is considered in the presence of different sources of noise, bringing to light the possibility of making the two qubits evolve in a synchronized way. A direct qubit–qubit interaction turns out to be a crucial ingredient, as well as the dissipation processes involving the resonator. The detrimental role of the local dephasing of the qubits is also taken into account.