Search results for "47"
showing 10 items of 1382 documents
The σ B -dependent regulatory sRNA Rli47 represses isoleucine biosynthesis in Listeria monocytogenes through a direct interaction with the ilvA trans…
2019
International audience; The facultative intracellular pathogen Listeria monocytogenes can persist and grow in a diverse range of environmental conditions, both outside and within its mammalian host. The alternative sigma factor Sigma B (sigma(B)) plays an important role in this adaptability and is critical for the transition into the host. While some of the functions of the sigma(B) regulon in facilitating this transition are understood the role of sigma(B)-dependent small regulatory RNAs (sRNAs) remain poorly characterized. In this study, we focused on elucidating the function of Rli47, a sigma(B)-dependent sRNA that is highly induced in the intestine and in macrophages. Using a combinatio…
Dictionnaire Adégien : Néologismes, régionalismes et mots d'argot dans l'oeuvre d'A.D.G., maître du néo-polar et amoureux des mots
2021
International audience; Alain Fournier dit A.D.G. (1947-2004) est à côté de Jean-Patrick Manchette, Jean-Bernard Pouy, Frédéric H. Fajardie et d'autres encore, l'un des représentants les plus importants du néo-polar, ce courant littéraire né en France dans les années 1970 qui a révolutionné, en le rajeunissant, le genre policier français. Écrivain mais aussi journaliste, ce natif de Touraine s'est établi à Paris mais il a passé une partie de sa vie en Nouvelle-Calédonie. Ces lieux ont servi de décors à ses romans, mais ils ont été aussi de véritables sources lexicales pour cet amoureux des mots. Car tout au long de son oeuvre, A.D.G. a forgé un style vigoureux et poétique, au vocabulaire fo…
“IN INGHILTERRA LA GIUSTIZIA È APERTA A TUTTI, COME L’HOTEL RITZ”. E IN ITALIA?
2015
L’aumento continuo e progressivo del contributo unificato in materia di appalti pubblici al vaglio della Corte di giustizia: le conclusioni dell'Avvocato generale.
Runs of homozygosity in the Italian goat breeds: impact of management practices in low-input systems
2021
Abstract Background Climate and farming systems, several of which are considered as low-input agricultural systems, vary between goat populations from Northern and Southern Italy and have led to different management practices. These processes have impacted genome shaping in terms of inbreeding and regions under selection and resulted in differences between the northern and southern populations. Both inbreeding and signatures of selection can be pinpointed by the analysis of runs of homozygosity (ROH), which provides useful information to assist the management of this species in different rural areas. Results We analyzed the ROH distribution and inbreeding (FROH) in 902 goats from the Italia…
Cancer‐associated venous thromboembolism: Treatment and prevention with rivaroxaban
2020
Abstract Cancer‐associated venous thromboembolism (VTE) is a frequent, potentially life‐threatening event that complicates cancer management. Anticoagulants are the cornerstone of therapy for the treatment and prevention of cancer‐associated thrombosis (CAT); factor Xa–inhibiting direct oral anticoagulants (DOACs; apixaban, edoxaban, and rivaroxaban), which have long been recommended for the treatment of VTE in patients without cancer, have been investigated in this setting. The first randomized comparisons of DOACs against low‐molecular‐weight heparin for the treatment of CAT indicated that DOACs are efficacious in this setting, with findings reflected in recent updates to published guidan…
La tipografía en el cine: : análisis de cabeceras y créditos de películas como estrategia educativa desde la cultura visual
2013
En el presente artículo se recogen un conjunto de relexiones sobre papel que adquieren los textos escritos utilizados como imágenes en el discurso cinematográico. Las letras del alfabeto han estado íntimamente unidas a la tradición del cine desde sus inicios. Esta atracción mutua que ha existido siempre entre el alfabeto y el cine ha generado un extraordinario legado que podemos analizar mediante los postulados de la cultura visual. Sugerimos la oportunidad de utilizar este elemento visual para solventar algunos errores, empobrecimientos, insuiciencias y déicits que pueden observarse en buena parte de los rituales educativos convencionales, ya que las letras como signos son artefactos visua…
Jumilla, arquitectura y urbanismo
2017
Mamá Antula: la beata de los ejercicios espirituales desde la mirada de los jesuitas desterrados
2016
Resumen: Cuando en 1767 Carlos III expulsó a los jesuitas, una beata: Mª Antonia de San José, asumió la responsabilidad de continuar con la labor de estos religiosos, centrándose en la realización de los Ejercicios Espirituales al modo de San Ignacio por la Provincia de Paraguay. Analizamos aquí la influencia de estos jesuitas en su actividad misional y algunos de los comentarios que hicieron durante su exilio. Palabras clave: jesuitas, beata, ejercicios espirituales, destierro Abstract: When in 1767 Charles III of Spain expelled the Jesuits, a devout woman: Maria Antonia de San José, continued their work focusing on the realization of the Ignatian Spiritual Exercises along the Province of …
Immune Thrombocytopenia: Recent Advances in Pathogenesis and Treatments
2021
Immune thrombocytopenia (ITP) is a rare autoimmune disease due to both a peripheral destruction of platelets and an inappropriate bone marrow production. Although the primary triggering factors of ITP remain unknown, a loss of immune tolerance—mostly represented by a regulatory T-cell defect—allows T follicular helper cells to stimulate autoreactive splenic B cells that differentiate into antiplatelet antibody-producing plasma cells. Glycoprotein IIb/IIIa is the main target of antiplatelet antibodies leading to platelet phagocytosis by splenic macrophages, through interactions with Fc gamma receptors (FcγRs) and complement receptors. This allows macrophages to activate autoreactive T cells …
The genetic heritage of Alpine local cattle breeds using genomic SNP data
2020
Abstract Background Assessment of genetic diversity and population structure provides important control metrics to avoid genetic erosion, inbreeding depression and crossbreeding between exotic and locally-adapted cattle breeds since these events can have deleterious consequences and eventually lead to extinction. Historically, the Alpine Arc represents an important pocket of cattle biodiversity with a large number of autochthonous breeds that provide a fundamental source of income for the entire regional economy. By using genotype data from medium-density single nucleotide polymorphism (SNP) arrays, we performed a genome-wide comparative study of 23 cattle populations from the Alpine Arc an…