Search results for "47"
showing 10 items of 1382 documents
Congreso de Jóvenes Investigadores/as I. "Espacio, redes y cultura en un mundo globalizado". Valencia, 22-23 de febrero de 2018
2018
Reseña de: Mínguez, Raúl. Evas, Marías y Magdalenas. Género y modernidad católica en la España liberal (1833-1874). Madrid: AHC-CEPC, 2016. 299 pgs.
2017
Reseña de: Mínguez, Raúl. Evas, Marías y Magdalenas. Género y modernidad católica en la España liberal (1833-1874). Madrid: AHC-CEPC, 2016. 299 pgs.
IFT46 Expression in the Nasal Mucosa of Primary Ciliary Dyskinesia Patients: Preliminary Study
2021
Este artículo se encuentra disponible en la siguiente URL: https://journals.sagepub.com/doi/pdf/10.1177/2152656721989288 Background: Primary ciliary dyskinesia (PCD) is characterised by an imbalance in mucociliary clearance leading to chronic respiratory infections. Cilia length is considered to be a contributing factor in cilia movement. Recently, IFT46 protein has been related to cilia length. Therefore, this work aims to study IFT46 expression in a PCD patients cohort and analyse its relationship with cilia length and function, as it was not previously described. Materials and methods: The expression of one intraflagellar transport (IFT46) and two regulating ciliary architecture (FOXJ1 a…
Sul nuovo rito dei licenziamenti e una proposta di modifica
2012
Lo studio propone una prima analisi delle norme che regolano il c.d. nuovo rito dei licenziamenti, introdotto dalla riforma Fornero, come complemento alla modificazione disciplina della reintegrazione e dei licenziamenti collettivi, allo scopo di snellire e accelerare i processi in questa materia e di aumentare la certezza in ordine alla risoluzione dei rapporti. Chiude lo studio un'appendice in cui l'autore propone un modello alternativo di rito dei licenziamenti.The study provides an initial analysis of the rules of the new trial of dismissals. It introduced by the Fornero reform, as a complement to the modification both dismissal reinstatement and collective redundancies. The purpos…
Voz cantada y Electromiografía de Superficie: Un estudio comparativo de la actividad muscular en cantantes formados y no formados
2018
En los últimos años ha habido un incremento del uso de la Electromiografía de Superficie en logopedia, lo que se evidencia en el número creciente de publicaciones en este área en revistas científicas. Este instrumento permite presentar de forma objetiva y precisa la actividad mioeléctrica en tiempo real, es no invasiva y se percibe de fácil aplicación. El objetivo de este trabajo es comparar la actividad mioeléctrica de los músculos maseteros, suprahioideos y esternoicleidomastoideos de cantantes con y sin entrenamiento vocal reglado a través de la Electromiografía de Superficie durante la realización de un fonetograma. La muestra estuvo conformada por 12 sopranos con edades entre 19 y 29 a…
Parasite presence induces gene expression changes in an ant host related to immunity and longevity
2021
Most species are either parasites or exploited by parasites, making parasite&ndash
“One Ring to Bind Them All”—Part II: Identification of Promising G-Quadruplex Ligands by Screening of Cyclophane-Type Macrocycles
2010
A collection of 26 polyammonium cyclophane-type macrocycles with a large structural diversity has been screened for G-quadruplex recognition. A two-step selection procedure based on the FRET-melting assay was carried out enabling identification of macrocycles of high affinity (ΔT1/2up to30°C) and high selectivity for the human telomeric G-quadruplex. The four selected hits possess sophisticated architectures, more particularly the presence of a pendant side-arm as well as the existence of a particular topological arrangement appear to be strong determinants of quadruplex binding. These compounds are thus likely to create multiple contacts with the target that may be at the origin of their h…
The distributions of protein coding genes within chromatin domains in relation to human disease.
2019
Abstract Background Our understanding of the nuclear chromatin structure has increased hugely during the last years mainly as a consequence of the advances in chromatin conformation capture methods like Hi-C. The unprecedented resolution of genome-wide interaction maps shows functional consequences that extend the initial thought of an efficient DNA packaging mechanism: gene regulation, DNA repair, chromosomal translocations and evolutionary rearrangements seem to be only the peak of the iceberg. One key concept emerging from this research is the topologically associating domains (TADs) whose functional role in gene regulation and their association with disease is not fully untangled. Resul…
SNPs detection by eBWT positional clustering
2019
Sequencing technologies keep on turning cheaper and faster, thus putting a growing pressure for data structures designed to efficiently store raw data, and possibly perform analysis therein. In this view, there is a growing interest in alignment-free and reference-free variants calling methods that only make use of (suitably indexed) raw reads data. We develop the positional clustering theory that (i) describes how the extended Burrows–Wheeler Transform (eBWT) of a collection of reads tends to cluster together bases that cover the same genome position (ii) predicts the size of such clusters, and (iii) exhibits an elegant and precise LCP array based procedure to locate such clusters in the e…
Multiplex Amplicon Quantification (MAQ), a fast and efficient method for the simultaneous detection of copy number alterations in neuroblastoma
2010
Abstract Background Cancer genomes display characteristic patterns of chromosomal imbalances, often with diagnostic and prognostic relevance. Therefore assays for genome-wide copy number screening and simultaneous detection of copy number alterations in specific chromosomal regions are of increasing importance in the diagnostic work-up of tumors. Results We tested the performance of Multiplex Amplicon Quantification, a newly developed low-cost, closed-tube and high-throughput PCR-based technique for detection of copy number alterations in regions with prognostic relevance for neuroblastoma. Comparison with array CGH and the established Multiplex Ligation-dependent Probe Amplification method…