Search results for "47"
showing 10 items of 1382 documents
Emblemi del Novecento. Cruciverba, linguaggio, luoghi comuni: faccette di storia culturale del Moderno
2009
Aikuisten maahanmuuttajien kotoutumiskoulutuksen tulosten ennustaminen lähtötason arviointien perusteella
2017
Artikkelissa selvitetään aikuisten maahanmuuttajien kotoutumiskoulutuksessa saavuttamaa suomen kielen taitoa ja sitä, ennustaako koulutuksen alussa tehtävä lähtötason arviointi saavutettua kielitaitoa. Tutkimukseen osallistuneet maahanmuuttajat (N = 286) osallistuivat lähtötason arviointiin Testipisteessä. Sen jälkeen he suorittivat kotoutumiskoulutuksen opinnot peruspolun tai hitaan opintopolun mukaisesti muutamassa pääkaupunkiseudun oppilaitoksessa. Testipisteen mallin mukaisessa lähtötason arvioinnissa selvitetään maahanmuuttajan suomen kielen taitoa ja opiskeluvalmiuksia testeillä ja taustatietoja keräämällä. Niiden pohjalta maahanmuuttaja ohjataan sopivimmalle opintopolulle ja kielitai…
Preprinting is positively associated with early career researcher status in ecology and evolution.
2021
Abstract The usage of preprint servers in ecology and evolution is increasing, allowing research to be rapidly disseminated and available through open access at no cost. Early Career Researchers (ECRs) often have limited experience with the peer review process, which can be challenging when trying to build publication records and demonstrate research ability for funding opportunities, scholarships, grants, or faculty positions. ECRs face different challenges relative to researchers with permanent positions and established research programs. These challenges might also vary according to institution size and country, which are factors associated with the availability of funding for open acces…
Succesio ab intestato: Concerning the death of Rodrigo de Mendoza, I Marquis of the Cenete
2017
La muerte de Rodrigo de Mendoza, I marqués del Cenete, sin testamento se vio envuelta de la incertidumbre propia del fallecimiento de un noble con un cuantioso patrimonio heredado en gran parte de su padre, el gran cardenal de España, sin especificar ni repartir y con tres hijas menores huérfanas sin un albacea designado por él. El gobernador general de Valencia, Lluís de Cabanyelles, del círculo más íntimo del marqués durante su estancia en la ciudad del Turia, junto a otros partícipes y testigos, impulsó el proceso de inventariado de todos sus bienes cuatro días después de su defunción, apelando, asimismo, al emperador Carlos V para que confirmase al virrey del reino de Valencia y hermano…
Analysis of DRD2 Gene Polymorphism in the Context of Personality Traits in a Group of Athletes
2021
The presented study showed the relationship between dopamine receptor gene polymorphism and personality traits in athletes training in martial arts. Behavioral modulation resulting from a balance of the neurotransmitters dopamine and norepinephrine to inactivation of the dorsolateral prefrontal cortex and dysregulation of various pathways involved in attention and impulse control processes
La Unión Liberal en el sistema político isabelino. Concepciones, alcances y limitaciones (1858-1863) The Liberal Union in the political Elizabethan s…
2017
Este artículo pretende revisar el estado actual de conocimientos sobre una formación política, la Unión Liberal, que presidió el Gobierno más largo y estable de la era isabelina. El unionismo es un proyecto político que tradicionalmente ha sufrido la desatención de la historiografía por ser considerado continuación o solución estratégica para que el moderantismo clásico se perpetuase en el poder. Mi investigación trata de cuestionar esta línea interpretativa y enfatizar que el unionismo puede agrietar más si cabe la tesis de la debilidad del liberalismo español.La Unión Liberal fue un experimento político, original e innovador, que bajo premisas ya contempladas en la cultura liberal, reinte…
Antithrombotics and new interventions for venous thromboembolism: Exploring possibilities beyond factor IIa and factor Xa inhibition.
2021
Abstract Direct oral anti–activated factor X and antithrombin agents have largely replaced vitamin K antagonists as the standard of care in treatment of venous thromboembolism. However, gaps in efficacy and safety persist, notably in end‐stage renal disease, implantable heart valves or assist devices, extracorporeal support of the circulation, and antiphospholipid syndrome. Inhibition of coagulation factor XI (FXI) emerges as a promising new therapeutic target. Antisense oligonucleotides offer potential advantages as a prophylactic or therapeutic modality, with one dose‐finding trial in orthopedic surgery already published. In addition, monoclonal antibodies blocking activation and/or activ…
INTEGRATED EFFICACY RESULTS FROM THE PHASE 2 AND PHASE 3 STUDIES WITH CAPLACIZUMAB IN PATIENTS WITH ACQUIRED THROMBOTIC THROMBOCYTOPENIC PURPURA
2021
Objective: An integrated analysis based on the Phase 2 TITAN (NCT01151423) and Phase 3 HERCULES (NCT02553317) studies with caplacizumab (CPLZ) in acquired thrombotic thrombocytopenic purpura (aTTP) was performed to assess treatment differences on efficacy and safety outcomes that may have been undetected in the individual trials. Methodology: In both trials, patients with an acute episode of aTTP were randomized to receive CPLZ or placebo (PBO) in addition to therapeutic plasma exchange (TPE) and immunosuppression. All randomized patients from both studies were included in the integrated efficacy analyses (CPLZ: n=108; PBO: n=112), and those who received at least 1 dose of the study drug we…
Effects of time of day on resistance exercise-induced anabolic signaling in skeletal muscle
2013
This study examined the effect of morning versus afternoon exercise on acute responses in phosphorylation of proteins regulating muscle size and metabolism. Twenty-two untrained men, divided into the morning (n = 11) or afternoon (n = 11) group, performed maximal isometric leg extensions before and after resistance loading at 07:30–08:30 h and 16:00–17:00 h, respectively. Muscle pre- and postloading biopsies were analyzed for phosphorylated Akt, p70S6K, rpS6, p38 mitogen-activated protein kinase (MAPK), Erk1/2, and eukaryotic elongation factor (eEF) 2. Muscle force declined after exercise in both groups (p < 0.001). p70S6K Thr389 (p < 0.05) and Thr421/Ser424 and rpS6 (all p < 0.001) increas…
Does aspirin save lives in patients with COVID-19?
2021
‘An aspirin a day keeps the heart attack away’, is this also true in the prevention of thrombotic events associated with COVID-19? The rising COVID-19 pandemic has led to much work in the understanding of the pathophysiology of the disease. COVID-19 infection is thought to be an endothelial disease. Supporting this concept, it has been suggested that infection with SARS-CoV-2, the aetiological agent for COVID-19 infection, leads to a state mimicking Virchow’s triad, that is, vascular endothelial injury, blood stasis and clotting in concert with systemic inflammation resulting in systemic thrombosis. In keeping with this concept, moderately and critically ill patients with COVID-19 have been…