Search results for "47"

The Fitness Effects of Random Mutations in Single-Stranded DNA and RNA Bacteriophages

2009

Mutational fitness effects can be measured with relatively high accuracy in viruses due to their small genome size, which facilitates full-length sequencing and genetic manipulation. Previous work has shown that animal and plant RNA viruses are very sensitive to mutation. Here, we characterize mutational fitness effects in single-stranded (ss) DNA and ssRNA bacterial viruses. First, we performed a mutation-accumulation experiment in which we subjected three ssDNA (ΦX174, G4, F1) and three ssRNA phages (Qβ, MS2, and SP) to plaque-to-plaque transfers and chemical mutagenesis. Genome sequencing and growth assays indicated that the average fitness effect of the accumulated mutations was similar…

Genome-Wide Haplotype Analysis of Cis Expression Quantitative Trait Loci in Monocytes

2013

In order to assess whether gene expression variability could be influenced by several SNPs acting in cis, either through additive or more complex haplotype effects, a systematic genome-wide search for cis haplotype expression quantitative trait loci (eQTL) was conducted in a sample of 758 individuals, part of the Cardiogenics Transcriptomic Study, for which genome-wide monocyte expression and GWAS data were available. 19,805 RNA probes were assessed for cis haplotypic regulation through investigation of ∼2,1×109 haplotypic combinations. 2,650 probes demonstrated haplotypic p-values >104-fold smaller than the best single SNP p-value. Replication of significant haplotype effects were tested f…

FOXP2 gene and language impairment in schizophrenia: association and epigenetic studies

2010

Abstract Background Schizophrenia is considered a language related human specific disease. Previous studies have reported evidence of positive selection for schizophrenia-associated genes specific to the human lineage. FOXP2 shows two important features as a convincing candidate gene for schizophrenia vulnerability: FOXP2 is the first gene related to a language disorder, and it has been subject to positive selection in the human lineage. Methods Twenty-seven SNPs of FOXP2 were genotyped in a cohort of 293 patients with schizophrenia and 340 controls. We analyzed in particular the association with the poverty of speech and the intensity of auditory hallucinations. Potential expansion of thre…

What You Should Know About Carbon Markets

2008

Since the entry into force of the Kyoto Protocol, carbon trading has been in continuous expansion. In this paper, we review the origins of carbon trading in order to understand how carbon trading works in Europe and, specifically, the functioning of the European Union Emission Trading Scheme (EU ETS) and the workings of several spot, futures and options markets where European Union Allowances are traded. As well, the linking of the EU ETS with the other United Nations carbon markets is also studied.

Historia del duque Carlos de Borgoña, bisaguelo del Emperador Carlos Quinto / el secretario Aguilon

1586

Sign.: A-N8, O4 Retrat de Carles, duc de Borgonya a cavall en O4 Port. amb esc. grav. - Capll.

Propositio facta per oratores Innocentii VIII coram Carolo VIII, Francorum rege

1488

Sign.: a6. - Data completa, d. 20 gener, 1488 L. gòt. - 33 lín. - Capll. grav

Teresa y Luis, Luis y Teresa. Dos santos en tiempos recios

2016

Resumen: El presente articulo analiza la relacion entre dos grandes santos espanoles de la Contrarreforma Catolica, Teresa de Jesus y el dominico fray Luis Bertran Palabras clave: Teresa de Jesus, Luis Bertran, Santos, Contrarreforma, Carmelitas Descalzos, Dominicos, Siglo XVI Abstract: The present article analyses the relation between two big Spanish saints of the Catholic Counter-reformation, Teresa de Jesus and the Dominican monk Luis Bertran Keywords : Teresa de Jesus, Luis Bertran, Saints, Counter-reformation, Discalced Carmelite, Dominicans, 16th century

Particularismes i populismes als països de llengua catalana

2020

[cat] L'article analitza breument l'ampla varietat de conceptes de populisme en la política actual. Aquesta anàlisi intenta mostrar com el populisme ha donat suport als particularismes lingüístics a València i a Mallorca. Aquests particularismes (anomenats blaverisme a València, i gonellisme a Mallorca) no reconeixen la unitat de la comunitat lingüística catalana, i per tant amenacen la recuperació social (normalització) de la llengua catalana.

Ejes vertebradores de la oligarquía urbana de Cataluña

1998

Vita Sanctae Catharinae Senensis / [per Nicolaum Burgensium

1501

Orla tip. grav. que envolta el tít. i la menció de responsabilitat en p. [6 Caplletra grav. en p. [8 Sign.: a6, b-n4, o6