Search results for "48"
showing 10 items of 1388 documents
Search for direct CP violation in the decays K-+/- -> 3 pi(+/-)
2006
Abstract We report a measurement of the direct CP violation asymmetry parameter A g in charged kaon decays K ± → π ± π + π − by the NA48/2 experiment at the CERN SPS. The experiment has been designed not to be limited by systematics in the asymmetry measurement. Using 1.67 × 10 9 such decays collected during the 2003 run, the charge asymmetry in the Dalitz plot linear slope parameter g has been measured to be A g = ( 1.7 ± 2.9 ) × 10 −4 . The precision of the result is limited by the statistics used.
Influence of the oncolytic parvovirus H-1, CTLA-4 antibody tremelimumab and cytostatic drugs on the human immune system in a human in vitro model of …
2013
Bernd Heinrich,* Katrin Goepfert,* Maike Delic, Peter R Galle, Markus MoehlerUniversity Medical Center of the Johannes Gutenberg University Mainz, 1st Department of Internal Medicine, Langenbeckstrasse, Mainz, Germany *These authors contributed equally to this workIntroduction: Tumor-directed and immune-system-stimulating therapies are of special interest in cancer treatment. Here, we demonstrate the potential of parvovirus H-1 (H-1PV) to efficiently kill colorectal cancer cells and induce immunogenicity of colorectal tumors by inducing maturation of dendritic cells (DCs) alone and also in combination with cytostatic drugs in vitro. Using our cell culture model, we have additionally investi…
Anaplastic Thyroid Cancer in Sicily: The Role of Environmental Characteristics
2017
Background: Anaplastic thyroid cancer (ATC) is a rare but extremely aggressive cancer of the thyroid, contributing up to 30-40% of thyroid cancer-specific mortality. We analyzed ATC characteristics and survival rates in Sicily to evaluate the possible influence of environmental factors. With this aim data regarding ATC incidences in urban/rural and industrial, iodine deficient and volcanic vs. control areas were compared in Sicily as well as ATC data from Sicily and USA. Methods: Using the Sicilian Register of Thyroid Cancer (SRTC) database incidence, age, gender, tumor size and histotype, extrathyroidal extension, stage and coexistence with pre-existing differentiated thyroid cancer (DTC) …
Medullary Thyroid Carcinoma With Exon 2 p.L56M RET Variant: Clinical Particular Features in Two Patients
2018
RET (REarranged during Transfection) proto-oncogene variants are essential for the development of familial and sporadic forms of medullary thyroid carcinoma (MTC). The most frequent variants are usually located in exons 10, 11, and 13 through 16 of the RET gene. We report two cases of apparently sporadic MTC associated with the variant in exon 2 of RET gene. Patient 1, a 62-year old man who had undergone adrenalectomy for a 5 cm pheochromocytoma, was screened for type 2 multiple endocrine neoplasia (MEN 2) which showed elevated basal and post-intravenous calcium gluconate calcitonin levels. A fine needle aspiration biopsy (FNAB) confirmed the suspicion of MTC. The patient underwent total th…
The Impact of Diet and Physical Activity on Bone Health in Children and Adolescents.
2021
There is growing recognition of the role of diet and physical activity in modulating bone mineral density, bone mineral content, and remodeling, which in turn can impact bone health later in life. Adequate nutrient composition could influence bone health and help to maximize peak bone mass. Therefore, children’s nutrition may have lifelong consequences. Also, physical activity, adequate in volume or intensity, may have positive consequences on bone mineral content and density and may preserve bone loss in adulthood. Most of the literature that exists for children, about diet and physical activity on bone health, has been translated from studies conducted in adults. Thus, there are still man…
Glucocorticoids in Graves’ orbitopathy: mechanisms of action and clinical application
2020
Background:Graves’ orbitopathy (GO) is the most frequent extrathyroidal manifestation of the autoimmune Graves’ disease. GO significantly impacts quality of life and has a psycho-social morbidity. Inflammation and swelling of the orbital tissue often leads to proptosis, diplopia, and decrease of visual acuity. Due to the inflammatory background of the disease, glucocorticoids (GC) have been used as a first-line treatment for decades.Methods:PubMed and MeSH database were searched for original articles, clinical trials, reviews, and meta-analyses published between 1 January 2000 and 31 March 2020 and pertaining to both the mechanism of action and immunological effects of GC as well as to the …
Argumentos retóricos sobre Interrupción Voluntaria del Embarazo en Colombia. Análisis jurisprudencial desde la teoría de la argumentación jurídica de…
2011
RESUMENEl presente trabajo aborda los conceptos planteados por Chaïm Perelman en su teoría de la argumentación, con el fin de lograr una comprensión del razonamiento en las decisiones judiciales tomadas por la Corte Constitucional de Colombia, en relación a tres casos sobre interrupción voluntaria del embarazo (IVE). En primer lugar, se aborda la teoría de la “Nueva Retórica” de Chaïm Perelman, y en especial su aplicación en el campo del Derecho. A continuación se hace un breve repaso de las premisas de la argumentación y las técnicas argumentativas manteniendo un enfoque de carácter jurídico. Para finalizar, se analiza la motivación de las sentencias de la Corte Constitucional colombiana …
Ara ojats queus notifiquen, y fan a saber de part de la S.C.R. Magestad, e per aquella. De part del Illustrissim ... Don Duart Fernando Aluarez de To…
1647
Caplletra ornada Sign. : [ ]2 Reclams
Vida del venerable, y apostolico prelado ... D. Luis Crespi de Borja, Obispo que fue de Orihuela, y Plasencia ... / Escriuela ... Fr. Tomas de la Res…
1676
Segons Palau amb el retrat del bisbe fet per Marcos Orozco Sign.: [*]3, **-****4, œ-œœœœœ4, A-Bbbb4, a-b4, œ4 Errates de pag.