Search results for "48"
showing 10 items of 1388 documents
Myriocin-induced adaptive laboratory evolution of an industrial strain of Saccharomyces cerevisiae reveals its potential to remodel lipid composition…
2020
The modification of lipid composition allows cells to adjust membrane biophysical properties in response to changes in environmental temperature. Here, we use adaptive laboratory evolution (ALE) in the presence of myriocin, a sphingolipid (SLs) biosynthesis inhibitor, to remodel the lipid profile of an industrial yeast strain (LH) of Saccharomyces cerevisiae. The approach enabled to obtain a heterogeneous population (LHev) of myriocin‐tolerant evolved clones characterized by its growth capacity at high temperature. Myriocin exposure also caused tolerance to soraphen A, an inhibitor of the acetyl‐CoA carboxylase Acc1, the rate‐limiting enzyme in fatty acid de novo production, supporting a ch…
Validity of multiplex biomarker model of 6 genes for the differential diagnosis of thyroid nodules
2011
Abstract Background Currently the cytological examination of fine needle aspiration (FNA) biopsies is the standard technique for the pre-operative differential diagnosis of thyroid nodules. However, the results may be non-informative in ~20% of cases due to an inadequate sampling and the lack of highly specific, measurable cytological criteria, therefore ancillary biomarkers that could aid in these cases are clearly needed. The aim of our study was to evaluate the mRNA expression levels of 8 candidate marker genes as the diagnostic biomarkers for the discrimination of benign and malignant thyroid nodules and to find a combination of biomarkers with the highest diagnostic value. Materials an…
Inhibition of giant cell formation by compound 48/80 after infection with herpesvirus hominis
1974
Choline kinase has been found to be a soluble enzyme with a molecular weight of 105,000 in the cytoplasm of primary rabbit kidney cells. It has been purified 150-fold. It was investigated whether the inhibiting effect of Cpd 48/80 on virus-induced giant cell formation is due to interference with this enzyme. Cpd 48/80-dimer was shown to inhibit the choline kinase activityin vitro without a concomitant inhibition of giant cell formation. Likewise, another competitive inhibitor of choline kinase, purinyl-6-histamine, does not prevent giant cell formation. This finding suggests that there is no correlation between choline kinase activity and giant cell formation.
A multilevel statistical toolkit to study animal social networks: the Animal Network Toolkit Software (ANTs) R package
2020
Abstract The possible role played by individual attributes, sociodemographic characteristics and/or ecological pressures in the interaction between animals and the development of social relationships between them is of great interest in animal ecology and evolutionary biology. Social Network Analysis is an ideal tool to study these types of questions. The Animal Network Toolkit Software (ANTs) R package was specifically developed to provide all the different social network analysis techniques currently used in the study of animal social networks. This global package enables users to (1) compute global, polyadic and nodal network measures; (2) perform data randomisation: data stream and netw…
Effect of environmental conditions on the durability of polycarbonate for the protection of cultural heritage sites.
2019
Polycarbonate is a good material for covering and protecting cultural heritage sites because of its durability, mechanical properties, and transparency. However, polycarbonate degrades under environmental weathering with a significant decrease of physical and mechanical properties and loss of transparency. In this work, the contemporary presence of ultraviolet irradiation and different temperature and moisture conditions have been taken into account to study the environmental degradation of this polymer with regard to its mechanical and optical properties. The photo-oxidation reactions cause a decrease in the molecular weight and the formation of many oxygenated species. The hydrolytic sci…
Vida, virtudes, milagros, y festivos cultos de Santo Thomas de Villanveva Arzobispo de Valencia, de la Orden de N.G.P. San Agustin / su autor Don Jos…
1731
Descripció física completa obtinguda del CCPB Sign.: [ ]1, ^-^₅4, A4, B-O2, P-Z, Aa-Kk4, Ll-Zz2, Aaa-Kkk4, Lll-Zzz, Aaaa2, Bbbb4, Cccc-Eeee2 Port. a 2 tintes amb orla tip. Text a 2 cols. - Notes a peu de p. - Reclams Gravat calc. signat per Tomàs Planes. - Caplletres orn., fris xil., culs de llàntia tip.
Ara ojats, queus fan asaber de part dels ... Iusticia, y Iurats de ... Valencia. Con ses Señories ha[n] tengut certes noticies. q[ue] ... Alexandre …
1659
Sig. [ ]3 Grav. de Sant Tomás de Villanueva i dels escuts del Regne i de la Ciutat en la 1 ̇p.
Solenidad festiua con que en la insigne, leal, noble y coronada ciudad de Valencia se celebrò la feliz nueva de la canonizacion de su milagroso Arç…
1659
Inclou, amb portadelles pròpies, sermons de Melcior Fuster, Josep Vicent de l'Olmo, Josep Sanchís, Antoni Bonaventura Guerau, Domingo Sarrio, Marcelo Marona, Cristóbal Abella i Jerónimo de Córdoba (p. 1-248 de la 2a sequència) Port. gravada calcogr. atribuïda a Gregorio Heredia (v. Ferran Salvador) F. de grav. calc. representant els Altars i un jeroglífic de les virtuts del sant, alguns d'ells signats per Juan Felipe (Páez. Repertorio 1, 723/6) i altres atribuïts a G. Heredia (Ferran Salvador) i Nicolás Viñerta (Palau) Grav. calc. intercal·lats al text representant els carros (Roques) dels distints gremis que ixen en la procesió del Corpus de València Caplletres orn. i culs-de…
Vida, virtudes, milagros, y festivos cultos de Santo Thomas de Villanueua Arzobispo de Valencia, de la Orden de N.G.P. San Agustin
Gravat calc. en el f. de làm.: "T. Planes sp. 1729" Port. amb orla tip Frisos, vinyetes, caplletres ornades, asteriscos, filets Descripció física completa obtinguda del CCPB Sign.: [ ]1, §1(2, §2(2), §3(2), §4(2), §5(2), A4, B-O2, P-Kkk4, Lll-Aaaa2, Bbbb4, Cccc-Eeee2 Port. a 2 tintes Text a 2 cols. - Notes a peu de pa 1 col. - Reclams
Ara ojats, queus fan asaber de part dels molts illustres señors iusticia, y jurats de dita ciutat de Valencia, com ses señories ha[n] tengut certes n…
Text signat per Vicent Felizes Escriva Precedeix el títol: "A llahor, honor, è gloria de nostre señor Deu Iesu Christ" Títol obtingut del començament del text Text datat a València el 18 d'abril de 1659 Signatures: [ ]3 Escuts calcogràfics de Jaume I i de València Caplletres ornades al començament de diversos paràgrafs Gravat de Sant Tomás de Villanueva "Pregó del Consell General de València sobre la canonització de Sant Tomàs de Villanova"