Search results for "49"
showing 10 items of 1208 documents
Oratio ad Innocentium VIII habita 11 Feb. 1485
1485
Sense sign. - Data completa, d. 11 febrer, 1485 Oratio ad Innocentium VIII pro Republica Senensium / Andreoccius de Chinucciis L. gòt. - 33-34 lín. - Esp. p. inic. - Filigr.: corn de caça. - Sense fol
Oratio ad Innocentium VIII, anno 1485 habita
1485
Sense sign. - Data completa, d. 27 abril, 1485 L. rom. - 33 lín. - Capll. grav. - Sense fol
Oratio de oboedientia ad Innocentium VIII
1485
Sense sign. - Data completa, d. 9 desembre, 1485 L. gòt. - 30-34 lín. - Min. p. inic. - Filigr.: balança encerclada
Sermo in publicatione confoederationis inter Innocentium VIII et Venetos
1487
Sense sign. - Data completa, d. 2 febrer, 1487 L. rom. - 33 lín. - Capll. grav. - Sense fol. - Filigr.: corn de caça
Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta.
2002
The integrins are a large family of heterodimeric transmembrane receptors composed of α and β subunits (22). In addition to mediating cell-matrix interactions, integrins have been shown to activate intracellular signaling pathways which, in collaboration with growth factor-induced signals, regulate cellular functions (46). Some integrin signaling cascades are activated via the β subunit cytoplasmic domain, and they are therefore triggered by several integrin heterodimers. These signals include the activation of protein tyrosine kinases of the Src and focal adhesion kinase (FAK) families (9, 47). More-recent studies have revealed signaling events that are activated specifically by an α subun…
β1D Integrin Inhibits Cell Cycle Progression in Normal Myoblasts and Fibroblasts
1998
Integrins are alphabeta heterodimeric transmembrane receptors involved in the regulation of cell growth and differentiation. The beta1 integrin subunit is widely expressed in vivo and is represented by four alternatively spliced cytoplasmic domain isoforms. beta1D is a muscle-specific variant of beta1 integrin and a predominant beta1 isoform in striated muscles. In the present study we showed that expression of the exogenous beta1D integrin in C2C12 myoblasts and NIH 3T3 or REF 52 fibroblasts inhibited cell proliferation. Unlike the case of the common beta1A isoform, adhesion of beta1D-transfected C2C12 myoblasts specifically via the expressed integrin did not activate mitogen-activated pro…
Transcription of α2 Integrin Gene in Osteosarcoma Cells Is Enhanced by Tumor Promoters
1998
Integrin alpha2beta1 is a heterodimeric transmembrane receptor for collagens. In osteogenic cells the expression of alpha2beta1 integrin is induced by both Kirsten sarcoma virus and chemical transformation. The association of alpha2 integrin with transformed cell phenotype was studied further by testing the effects of two tumor promoters, 12-O-tetradecanoylphorbol 13-acetate (TPA) and okadaic acid (OA), on human MG-63 osteosarcoma cells. TPA, an activator of protein kinase C, increased the cell surface expression of alpha2 integrin and the corresponding mRNA levels. Nuclear run-on assays indicated that TPA activated the transcription of alpha2 integrin gene. TPA also slightly increased the …
Internacionalismo juglar en la corte de Carlos II y Carlos III de Navarra (1349-1425)
1963
Anthropogenic soils: general aspects and features
2015
In recent decades man's role in soil formation has become a matter of great concern among soil scientists. Man is now considered a soil-forming factor and anthrosolization is recognised as a soil-forming process that consists of a collection of geomorphic and pedological processes resulting from human activities. These human activities include deep working, intensive fertilization, the addition of extraneous materials, irrigation with sediment-rich waters and wet cultivation. In this paper we review the influence of man as a soil forming factor stressing also some peculiar aspects linked to their classification.