Search results for "4a"
showing 10 items of 178 documents
p14ARF re-expression induces apoptosis in aneuploid HCT116 cells
2012
Weakening the Spindle Assembly Checkpoint by reduced expression of its components such as MAD2, BubR1 and MPS1 induces chromosome instability and aneuploidy both hallmarks of cancer cells. p14ARF that is found frequently altered in human cancers, is overexpressed in response to oncogenic stimuli to stabilize p53 halting cell progression. Previously, we determined that lack or reduced expression of p14ARF is involved in the maintenance of aneuploid cells suggesting that it could be part of a pathway controlling proliferation of aneuploidy cells. To investigate further this aspect of p14ARF function it was ectopically expressed in HCT116 cells, a stable near diploid cell line, after MAD2 depl…
Identification of molecular markers involved in cellular response to aneuploidy in normal and tumor cells
2020
La valutazione dell'iperespressione della proteina p16INK4a come possibile biomarcatore prognostico nelle lesioni cervicali intraepiteliali di basso …
2014
Prognostic significance of p16INK4a alterations and 9p21 loss of heterozigosity in locally advanced laryngeal squamous cell carcinoma
2002
The p16INK4a gene, localized within chromosome 9p21, has been identified as a cyclin-dependent kinase inhibitor and may negatively regulate the cell cycle acting as a tumor suppressor. Genetic alterations involving the 9p21 region are common in human cancers. A consecutive series of 64 untreated patients (median of follow up 53 months) undergoing surgical resection for locally advanced laryngeal squamous-cell carcinomas (LSCCs) has been studied prospectively. Our purpose was to investigate p16 alterations (9p21 allelic loss, hypermethylation and point mutations) and their possible association with clinico-pathological data and flow cytometric variables (DNA-ploidy and S-phase fraction (SPF)…
CCDC 247963: Experimental Crystal Structure Determination
2005
Related Article: H.Kivela, Z.Zalan, P.Tahtinen, R.Sillanpaa, F.Fulop, K.Pihlaja|2005|Eur.J.Org.Chem.|2005|1189|doi:10.1002/ejoc.200400611
CCDC 1964840: Experimental Crystal Structure Determination
2019
Related Article: Ferenc Miklós, Kristof Bozó, Zsolt Galla, Matti Haukka, Ferenc Fülöp|2017|Tetrahedron:Asymm.|28|1401|doi:10.1016/j.tetasy.2017.07.006
CCDC 1964842: Experimental Crystal Structure Determination
2019
Related Article: Ferenc Miklós, Kristof Bozó, Zsolt Galla, Matti Haukka, Ferenc Fülöp|2017|Tetrahedron:Asymm.|28|1401|doi:10.1016/j.tetasy.2017.07.006
CCDC 1583208: Experimental Crystal Structure Determination
2018
Related Article: Nicolas Sok, Claire Bernhard, Pauline Désogère, Christine Goze, Yoann Rousselin, Frédéric Boschetti, Isabelle Baglin, Franck Denat|2018|Eur.J.Org.Chem.|2018|4762|doi:10.1002/ejoc.201800801
CCDC 902371: Experimental Crystal Structure Determination
2013
Related Article: P.Desogere,C.Bernhard,C.Goze,M.-J.Penouilh,Y.Rousselin,F.Denat|2013|Eur.J.Org.Chem.|2013|1538|doi:10.1002/ejoc.201201337
CCDC 902370: Experimental Crystal Structure Determination
2013
Related Article: P.Desogere,C.Bernhard,C.Goze,M.-J.Penouilh,Y.Rousselin,F.Denat|2013|Eur.J.Org.Chem.|2013|1538|doi:10.1002/ejoc.201201337