Search results for "4a"
showing 10 items of 178 documents
"Delirium Day": a nationwide point prevalence study of delirium in older hospitalized patients using an easy standardized diagnostic tool
2016
Background To date, delirium prevalence in adult acute hospital populations has been estimated generally from pooled findings of single-center studies and/or among specific patient populations. Furthermore, the number of participants in these studies has not exceeded a few hundred. To overcome these limitations, we have determined, in a multicenter study, the prevalence of delirium over a single day among a large population of patients admitted to acute and rehabilitation hospital wards in Italy. Methods This is a point prevalence study (called “Delirium Day”) including 1867 older patients (aged 65 years or more) across 108 acute and 12 rehabilitation wards in Italian hospitals. Delirium wa…
Next-generation sequencing confirms the implication of SLC24A1 in autosomal-recessive congenital stationary night blindness.
2015
Congenital stationary night blindness (CSNB) is a clinically and genetically heterogeneous retinal disorder which represents rod photoreceptor dysfunction or signal transmission defect from photoreceptors to adjacent bipolar cells. Patients displaying photoreceptor dysfunction show a Riggs-electroretinogram (ERG) while patients with a signal transmission defect show a Schubert-Bornschein ERG. The latter group is subdivided into complete or incomplete (ic) CSNB. Only few CSNB cases with Riggs-ERG and only one family with a disease-causing variant in SLC24A1 have been reported. Whole-exome sequencing (WES) in a previously diagnosed icCSNB patient identified a homozygous nonsense variant in SL…
Beneficial effects of C1 esterase inhibitor in ST-elevation myocardial infarction in patients who underwentsurgical reperfusion: a randomized double-…
2007
Background: The inflammatory cascade has been hypothesized to be an important mechanism of post-ischaemic myocardial reperfusion injury and several studies demonstrated that C1 esterase inhibitor (C1 -INH) is effective in post-ischaemia myocardial protection. Therefore, we aimed to investigate prospectively in a randomised double-blind study the cardioprotective effects of C1-INH in ST segment elevation myocardial infarction (STEMI) in patients who underwent emergent reperfusion with coronary artery bypass grafting (CABG). Methods: In this study, we enrolled 80 patients affected with STEMI who underwent emergent CABG. Patients were assigned in two groups (C1-INH group: receive 1000 Ul of C1…
ATP4A autoimmunity in pediatric patients with type 1 diabetes and its relationship to blood count, iron metabolism, and vitamin B12
2017
Objective We aimed to assess the prevalence of autoantibodies against the 4A subunit of the gastric proton pump (ATP4A) in pediatric type 1 diabetes (T1D) patients and explore the relationship between ATP4A positivity and blood cell count, iron turnover, and vitamin B12 concentration. Subjects The study included 94 (59% female) T1D children (aged 12.5 ± 4.1 years, T1D duration 4.2 ± 3.6 years, HbA1c 7.3 ± 1.5% (57 ± 12.6 mmol/mol) with no other autoimmune diseases. Methods ATP4A antibodies were measured in T1D patients using a radioimmunoprecipitation assay. Blood cell count, iron concentration, total iron binding capacity, ferritin, transferrin, hepcidin, and vitamin B12 concentration were…
Difference between Guinea Pig and Rat in the Liver Peroxisomal Response to Equivalent Plasmatic Level of Ciprofibrate
1996
Abstract Guinea pig was previously classified as a species nonresponsive to peroxisome proliferators. However, none of the previous reports was based on pharmacokinetic data. Here, after a comparative pharmacokinetic study between guinea pig and rat, we evaluate the guinea pig liver peroxisomal response to ciprofibrate, a hypolipemic agent and a potent peroxisome proliferator in rat. (1) Pharmacokinetic results show that plasmatic concentrations of ciprofibrate are equivalent in guinea pig and rat when guinea pigs are treated with ciprofibrate at 30 mg/kg twice a day and rats are treated at 3 mg/kg once a day. (2) The treatment of guinea pigs at 30 mg/kg twice a day for 2 weeks leads to a s…
Role of thyroid state on induction by ciprofibrate of laurate hydroxylase and peroxisomal enzymes in rat liver microsomes.
1993
The effects of hypothyroidism and hyperthyroidism upon liver microsomal omega-laurate hydroxylase activity (cytochrome P450 IV A1-dependent), peroxisome proliferation marker enzyme activities and acyl CoA oxidase (AOX) expression induced by ciprofibrate (2 mg/kg/day during 8 days) were studied in the male Wistar rat so as to clarify firstly the possible involvement of thyroid hormones in the modification of peroxisomal ciprofibrate-induced enzyme activities in relation to hepatic microsomal cytochrome P450 IV A1 induction, and secondly the possible direct effect of thyroid hormones on the gene expression of specific peroxisomal enzymes. No significant change was found in the ciprofibrate-in…
Milnor-Witt Motives
2020
We develop the theory of Milnor-Witt motives and motivic cohomology. Compared to Voevodsky's theory of motives and his motivic cohomology, the first difference appears in our definition of Milnor-Witt finite correspondences, where our cycles come equipped with quadratic forms. This yields a weaker notion of transfers and a derived category of motives that is closer to the stable homotopy theory of schemes. We prove a cancellation theorem when tensoring with the Tate object, we compare the diagonal part of our Milnor-Witt motivic cohomology to Minor-Witt K-theory and we provide spectra representing various versions of motivic cohomology in the $\mathbb{A}^1$-derived category or the stable ho…
Some sufficient conditions for lower semicontinuity in SBD and applications to minimum problems of Fracture Mechanics
2009
We provide some lower semicontinuity results in the space of special functions of bounded deformation for energies of the type $$ %\int_\O {1/2}({\mathbb C} \E u, \E u)dx + \int_{J_{u}} \Theta(u^+, u^-, \nu_{u})d \H^{N-1} \enspace, \enspace [u]\cdot \nu_u \geq 0 \enspace {\cal H}^{N-1}-\hbox{a. e. on}J_u, $$ and give some examples and applications to minimum problems. \noindent Keywords: Lower semicontinuity, fracture, special functions of bounded deformation, joint convexity, $BV$-ellipticity.
Geodesic ray transform with matrix weights for piecewise constant functions
2019
We show injectivity of the geodesic X-ray transform on piecewise constant functions when the transform is weighted by a continuous matrix weight. The manifold is assumed to be compact and nontrapping of any dimension, and in dimension three and higher we assume a foliation condition. We make no assumption regarding conjugate points or differentiability of the weight. This extends recent results for unweighted transforms.
X-ray Tomography of One-forms with Partial Data
2021
If the integrals of a one-form over all lines meeting a small open set vanish and the form is closed in this set, then the one-form is exact in the whole Euclidean space. We obtain a unique continuation result for the normal operator of the X-ray transform of one-forms, and this leads to one of our two proofs of the partial data result. Our proofs apply to compactly supported covector-valued distributions.