Search results for "4aS*"
showing 10 items of 178 documents
Search for multiwavelength emission from the binary millisecond pulsar PSR J1836-2354A in the globular cluster M22
2019
We present a multi-band search for X-ray, optical and $\gamma$-ray emission of the radio binary millisecond pulsar J1836-2354A, hosted in the globular cluster M22. X-ray emission is significantly detected in two Chandra observations, performed in 2005 and 2014, at a luminosity of $\sim$2-3$\times$10$^{30}$ erg s$^{-1}$, in the 0.5-8 keV energy range. The radio and the X-ray source positions are found consistent within 1$\sigma$ error box. No detection is found in archival XMM-Newton and Swift/XRT observations, compatible with the Chandra flux level. The low statistics prevents us to assess if the X-ray source varied between the two observations. The X-ray spectrum is consistent with a power…
Torus computed tomography
2020
We present a new computed tomography (CT) method for inverting the Radon transform in 2D. The idea relies on the geometry of the flat torus, hence we call the new method Torus CT. We prove new inversion formulas for integrable functions, solve a minimization problem associated to Tikhonov regularization in Sobolev spaces and prove that the solution operator provides an admissible regularization strategy with a quantitative stability estimate. This regularization is a simple post-processing low-pass filter for the Fourier series of a phantom. We also study the adjoint and the normal operator of the X-ray transform on the flat torus. The X-ray transform is unitary on the flat torus. We have i…
Possible protective role for C-reactive protein in atherogenesis: complement activation by modified lipoproteins halts before detrimental terminal se…
2004
Background—Previous work indicated that enzymatically remodeled LDL (E-LDL) might activate complement in atherosclerotic lesions via a C-reactive protein (CRP)–dependent and CRP-independent pathway. We sought to substantiate this contention and determine whether both pathways drive the sequence to completion.Methods and Results—E-LDL was prepared by sequential treatment of LDL with a protease and cholesteryl esterase. Trypsin, proteinase K, cathepsin H, or plasmin was used with similar results. Functional tests were used to assess total complement hemolytic activity, and immunoassays were used to demonstrate C3 cleavage and to quantify C3a, C4a, C5a, and C5b-9. E-LDL preparations activated …
A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2
2009
BACKGROUND: Common polymorphisms have been identified in genes suspected to play a role in asthma. We investigated their associations with wheeze and allergy in a case-control sample from Phase 2 of the International Study of Asthma and Allergies in Childhood. METHODS: We compared 1105 wheezing and 3137 non-wheezing children aged 8-12 years from 17 study centres in 13 countries. Genotyping of 55 candidate single nucleotide polymorphisms (SNPs) in 14 genes was performed using the Sequenom System. Logistic regression models were fitted separately for each centre and each SNP. A combined per allele odds ratio and measures of heterogeneity between centres were derived by random effects meta-ana…
Regularization of perturbed state-dependent sweeping processes with nonregular sets
2018
International audience; In this paper, we prove the convergence strongly pointwisely (up to a subsequence) of Moreau-Yosida regularization of perturbed state-dependent sweeping process with nonregular (subsmooth and positively alpha-far) sets in separable Hilbert spaces. Some relevant consequences are indicated.
A new class of spaces with all finite powers Lindelof
2013
We consider a new class of open covers and classes of spaces defined from them, called "iota spaces". We explore their relationship with epsilon-spaces (that is, spaces having all finite powers Lindelof) and countable network weight. An example of a hereditarily epsilon-space whose square is not hereditarily Lindelof is provided.
Interaction of 68–kDa TAR RNA-binding protein and other cellular proteins with rpion protein-RNA stem-loop
1995
The RNA stem-loop structure of the trans-activating region TAR sequence of human immunodeficiency virus-1 mRNA is the binding site for a number of host cell proteins. A virtually identical set of proteins from HeLa nuclear extracts was found to bind to the predicted RNA hairpin element of prion protein (PrP) mRNA, as demonstrated in UV cross-linking/RNase protection and Northwestern assays. We show that the cellular TAR loop-binding protein, p68, is among those proteins which associate with PrP RNA. Competition experiments with various TAR RNA mutants revealed that binding of partially purified p68 to PrP RNA stem-loop occurs sequence-specifically. The 100-kDa 2-5A synthetase which is invol…
Differential proteomic analysis of an engineered Streptomyces coelicolor strain reveals metabolic pathways supporting growth on n-hexadecane
2012
The alkB gene, encoding an alkane monooxygenase in the actinomycete Gordonia sp. SoCg, was expressed in the non-alkane-degrading actinomycete Streptomyces coelicolor M145. The resulting engineered strain, M145-AH, can grow on n-hexadecane as sole carbon source. To unravel proteins associated with growth on n-alkanes, proteome of M145-AH after 6, 24, and 48 h of incubation in the Bushnell-Haas (BH) mineral medium containing n-hexadecane as sole carbon source (H condition) and in BH without any carbon source (0 condition) were compared using 2D-differential gel electrophoresis. Proteome analysis revealed significant changes only at 48 h, showing 48 differentially abundant proteins identified …
Null alleles of human complement C4. Evidence for pseudogenes at the C4A locus and for gene conversion at the C4B locus
1990
The two genes for the C4A and C4B isotypes of the fourth component of human complement are located in the MHC class III region. Previous studies have demonstrated the unusual expression of C4 genes in the form of aberrant or duplicated haplotypes. Null alleles of C4A or C4B (AQ0 or BQ0) have been defined by the absence of gene products and occur at frequencies of 0.1-0.3. However, only some C4 null alleles are due to gene deletions, the remainder were thought to be nonexpressed genes. We have analyzed the C4 gene structure of 26 individuals lacking either C4A or C4B protein. The DNA of individuals with apparently nonexpressed C4 genes was tested for the presence of C4A- and C4B-specific seq…
Unique continuation property and Poincar�� inequality for higher order fractional Laplacians with applications in inverse problems
2020
We prove a unique continuation property for the fractional Laplacian $(-\Delta)^s$ when $s \in (-n/2,\infty)\setminus \mathbb{Z}$. In addition, we study Poincar\'e-type inequalities for the operator $(-\Delta)^s$ when $s\geq 0$. We apply the results to show that one can uniquely recover, up to a gauge, electric and magnetic potentials from the Dirichlet-to-Neumann map associated to the higher order fractional magnetic Schr\"odinger equation. We also study the higher order fractional Schr\"odinger equation with singular electric potential. In both cases, we obtain a Runge approximation property for the equation. Furthermore, we prove a uniqueness result for a partial data problem of the $d$-…