Search results for "5-HT receptor"
showing 2 items of 52 documents
Polymorphisms in the Serotonin (5-Hydroxytryptamine (5-HT)) Type 2A Receptor (5-HTR2A) Gene, Other Related Genes and Anthropometry
2012
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter, which helps to regulate many physiological processes such as sleep, appetite, eating disorders, thermoregulation, hormone secretion, mood, anxiety, etc. The serotonin and related genes, such as the 5-HT2A receptor gene (HTR2A), the 5-HT transporter gene (SLC6A4), the 5-HT2C receptor gene (HTR2C), or the 5-HT1A receptor (HTR1A) gene, are re-emerging as powerful candidates for studying the association between food intake and anthropometry. Variations in all of these genes need to be studied to better understand the effects of serotonin and its receptors on anthropometry. The most widely studied polymorphism is the −1438G…
Preferential Modulation of the GABAergic vs. Dopaminergic Function in the Substantia Nigra by 5-HT2C Receptor
2009
Serotonin (5-HT) is intimately involved in the modulation of the basal ganglia circuitry and in its pathologies. The 5-HT pivotal role is supported by anatomical evidence demonstrating a large serotonergic innervation throughout the basal ganglia, with the highest concentration of this indole in the substantia nigra (SN). Among all the 5-HT receptors present in the SN, the 5-HT2C receptor subtype seems to be one of the principal receptors through which 5-HT exerts its function. In this chapter, we present in vivo electrophysiology and microdialysis evidence showing that the selective activation of 5-HT2C receptors does not affect dopaminergic function whereas it has a profound impact on GAB…