Search results for "5-dihydro-1"

showing 10 items of 63 documents

Clearance and metabolism of arachidonic acid by C6 glioma cells and astrocytes.

1995

Effects of increased levels of arachidonic acid (AA) were analyzed in vitro by employment of C6 glioma cells and astrocytes from primary culture. The cells were suspended in a physiological medium added with arachidonic acid (AA) in a concentration range from 0.01 to 0.5 mM. The concentration profiles of the fatty acid and AA-metabolites were subsequently followed for 90 min. AA was measured by gas chromatography, whereas the AA-metabolites PGF2 alpha and LTB4 by radioimmunoassay (RIA). Following administration of AA at 0.05 or 0.1 mM the medium was completely cleared from the fatty acid within 10 to 15 min. However, when 0.5 mM were added, AA concentrations of 0.36 +/- 0.055 mM were found …

medicine.medical_specialty45-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amineBiologyDinoprostBiochemistryLeukotriene B4Cellular and Molecular NeuroscienceLipoxygenasechemistry.chemical_compoundInternal medicinemedicineTumor Cells CulturedCyclooxygenase InhibitorsLipoxygenase Inhibitorschemistry.chemical_classificationArachidonic AcidFatty acidRadioimmunoassayGeneral MedicineMetabolismGliomaCulture MediaKineticsEndocrinologymedicine.anatomical_structurechemistryCell cultureAstrocytesbiology.proteinNeurogliaArachidonic acidAstrocyteNeurochemical research
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Mechanisms of arachidonic acid induced glial swelling

2000

Accumulation of arachidonic acid (AA) in the brain during ischaemia may contribute to development of brain oedema. In this study we investigated the effect of selected drugs on AA-induced cytotoxic brain oedema in C6 glioma cells. Suspended C6 glioma cells were preincubated with drugs and AA (0.1 mM) was added. When no drug was administered cell volume increased immediately after the addition of AA with a maximum cell swelling of 13.1+/-1.9% at 15 min (mean +/- S.E. M.). Preincubation of cells with BW 755C, a dual inhibitor of cyclo- and lipoxygenases, showed no reduction in cell swelling from AA, whereas superoxide dismutase, amiloride and the protein kinase inhibitor H-9370 led to a signi…

medicine.drug_classModels Neurological45-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amineBrain EdemaPharmacologyAmilorideSuperoxide dismutaseCellular and Molecular Neurosciencechemistry.chemical_compoundTumor Cells CulturedmedicineAnimalsCytotoxic T cellEnzyme InhibitorsOuabainMolecular BiologyCell SizeArachidonic AcidbiologySuperoxide DismutaseGliomaProtein kinase inhibitorIn vitroAmiloridemedicine.anatomical_structurechemistryCell cultureImmunologybiology.proteinNeurogliaArachidonic acidNeurogliamedicine.drugMolecular Brain Research
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CCDC 1549500: Experimental Crystal Structure Determination

2017

Related Article: Brian M. Barry, R. Graeme Soper, Juha Hurmalainen, Akseli Mansikkamäki, Katherine N. Robertson, William L. McClennan, Alex J. Veinot, Tracey L. Roemmele, Ulrike Werner-Zwanziger, René T. Boeré, Heikki M. Tuononen, Jason A. C. Clyburne, Jason D. Masuda|2018|Angew.Chem.,Int.Ed.|57|749|doi:10.1002/anie.201711031

2-{[4-(chloroethynyl)phenyl]ethynyl}-13-bis[26-bis(propan-2-yl)phenyl]-45-dihydro-1H-imidazol-3-ium 2-{[4-(bromoethynyl)phenyl]ethynyl}-13-bis[26-bis(propan-2-yl)phenyl]-45-dihydro-1H-imidazol-3-ium tetraphenylborate dichloromethane solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 2044705: Experimental Crystal Structure Determination

2021

Related Article: Sergiu Calancea, Luca Carrella, Teodora Mocanu, Vladimir Sadohin, Mihai Raduca, Iacob Gutu, Julio C. Rocha, Maria G. F. Vaz, Eva Rentschler, Marius Andruh|2021|Eur.J.Inorg.Chem.|2021|567|doi:10.1002/ejic.202000954

bis(mu-4455-tetramethyl-3-oxo-2-(5-phenyl-1H-pyrazol-4-yl)-45-dihydro-1H-3-imidazol-1-oxyl)-hexakis(111555-hexafluoroacetylacetonato)-di-gadolinium(iii)Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1475564: Experimental Crystal Structure Determination

2016

Related Article: Torben Kienz, Christoph Förster, and Katja Heinze|2016|Organometallics|35|3681|doi:10.1021/acs.organomet.6b00619

Space GroupCrystallographyCrystal System3-(ferrocen-1-yl)-5-((ferrocen-1-yl)(1-((ferrocen-1-yl)iminio)ethyl)amino)-2-methyl-45-dihydro-13-thiazol-3-ium bis(hexafluoro-antimony) dichloromethane solvateCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 984540: Experimental Crystal Structure Determination

2014

Related Article: L. Koskinen, P. Hirva, E. Kalenius, S. Jääskeläinen, K. Rissanen, M. Haukka|2015|CrystEngComm|17|1231|doi:10.1039/C4CE01735H

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersbis(22'-(iodoniumdiyldisulfanediyl)bis(45-dihydro-1H-imidazol-3-ium)) iodide triiodideExperimental 3D Coordinates
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CCDC 1444032: Experimental Crystal Structure Determination

2016

Related Article: Fares Ibrahim Amr, Carlos Vila, Gonzalo Blay, M. Carmen Muñoz and José R. Pedro|2016|Adv.Synth.Catal.|358|1583|doi:10.1002/adsc.201600036

t-butyl (1-benzyl-5-chloro-3-(34-dimethyl-5-oxo-1-phenyl-45-dihydro-1H-pyrazol-4-yl)-2-oxo-23-dihydro-1H-indol-3-yl)carbamateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 2060888: Experimental Crystal Structure Determination

2021

Related Article: Lucija Ptiček, Lucija Hok, Petra Grbčić, Filip Topić, Mario Cetina, Kari Rissanen, Sandra Kraljević Pavelić, Robert Vianello, Livio Racané|2021|Org.Biomol.Chem.|19|2784|doi:10.1039/D1OB00235J

hydrogen bis(2-(3-amino-4-oxyphenyl)-45-dihydro-1H-imidazol-3-ium) chloride tetrahydrateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 906031: Experimental Crystal Structure Determination

2013

Related Article: Pekka K.Poutiainen ,Jorma J.Palvimo,Ari E.Hinkkanen,Arto Valkonen,Topi K.Vaisanen,Reino Laatikainen,Juha T.Pulkkinen|2013|J.Med.Chem.|56|1064|doi:10.1021/jm301516q

5-(4-Fluorobenzyl)-3-(4-methoxyphenyl)-45-dihydro-12-oxazoleSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 699684: Experimental Crystal Structure Determination

2009

Related Article: M.Jung, A.Sharma, D.Hinderberger, S.Braun, U.Schatzschneider, E.Rentschler|2009|Eur.J.Inorg.Chem.||1495|doi:10.1002/ejic.200801248

Space GroupCrystallographyCrystal SystemCrystal Structure(mu~2~-4-(4455-Tetramethyl-45-dihydro-1H-imidazol-2-yl 3-oxide 1-oxyl)benzoato radical-OO')-(mu~2~-NNN'N'-tetrakis((1-(n-propyl)benzimidazol-2-yl)methyl)-2-oxidopropane-13-diamine-NN'N''N'''N''''N'''''OO)-di-cobalt(ii) diperchlorate diethyl ether solvateCell ParametersExperimental 3D Coordinates
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