Search results for "5-tetrazine"
showing 2 items of 32 documents
CCDC 1942013: Experimental Crystal Structure Determination
2020
Related Article: Antonio A. Garcı́a-Valdivia, Manuel Pérez-Mendoza, Duane Choquesillo-Lazarte, Javier Cepeda, Belén Fernández, Manuel Souto, Marcos González-Tejero, Jose A. Garcı́a, Guillermo Mı́nguez Espallargas, Antonio Rodrı́guez-Diéguez|2020|Cryst.Growth Des.|20|4550|doi:10.1021/acs.cgd.0c00345
Ortho -Functionalized Aryltetrazines by Direct Palladium-Catalyzed C−H Halogenation: Application to Fast Electrophilic Fluorination Reactions
2016
International audience; A general catalyzed direct C-H functionalization of s-tetrazines is reported. Under mild reaction conditions, N-directed ortho-C-H activation of tetrazines allows the introduction of various functional groups, thus forming carbon-heteroatom bonds: C-X (X=I, Br, Cl) and C-O. Based on this methodology, we developed electrophilic mono- and poly-ortho-fluorination of tetrazines. Microwave irradiation was optimized to afford fluorinated s-aryltetrazines, with satisfactory selectivity, within only ten minutes. This work provides an efficient and practical entry for further accessing highly substituted tetrazine derivatives (iodo, bromo, chloro, fluoro, and acetate precurso…