Search results for "507"
showing 10 items of 575 documents
Immunoproteasome LMP2 60HH Variant Alters MBP Epitope Generation and Reduces the Risk to Develop Multiple Sclerosis in Italian Female Population
2010
BackgroundAlbeit several studies pointed out the pivotal role that CD4+T cells have in Multiple Sclerosis, the CD8+ T cells involvement in the pathology is still in its early phases of investigation. Proteasome degradation is the key step in the production of MHC class I-restricted epitopes and therefore its activity could be an important element in the activation and regulation of autoreactive CD8+ T cells in Multiple Sclerosis.Methodology/principal findingsImmunoproteasomes and PA28-alphabeta regulator are present in MS affected brain area and accumulated in plaques. They are expressed in cell types supposed to be involved in MS development such as neurons, endothelial cells, oligodendroc…
Alcohol-impaired Walking in 16 Countries: A Theory-Based Investigation.
2021
Alcohol is a global risk factor for road trauma. Although drink driving has received most of the scholarly attention, there is growing evidence of the risks of alcohol-impaired walking. Alcohol-impaired pedestrians are over-represented in fatal crashes compared to non-impaired pedestrians. Additionally, empirical evidence shows that alcohol intoxication impairs road-crossing judgements. Besides some limited early research, much is unknown about the global prevalence and determinants of alcohol-impaired walking. Understanding alcohol-impaired walking will support health promotion initiatives and injury prevention. The present investigation has three aims: (1) compare the prevalence of alcoho…
Genetic variants in a sodium-dependent vitamin C transporter gene and age-related cataract
2018
BACKGROUND: Cataract is a major health burden in many countries and a significant problem in India. While observational studies show lower cataract risk with increasing dietary or plasma vitamin C, randomised controlled trials of supplements have been negative. Genetic variants in vitamin C transporter proteins (SLC23A1), especially rs33972313, may provide evidence on a causal association of vitamin C with cataract. METHODS: We used data from a randomly selected population-based study in people aged 60 years and above in north and south India. Of 7518 sampled, 5428 (72%) were interviewed for socioeconomic and lifestyle factors, attended hospital for lens imaging and blood collection and wer…
Is cancer risk of radiation workers larger than expected?
2009
Occupational exposures to ionising radiation mainly occur at low-dose rates and may accumulate effective doses of up to several hundred milligray. The objective of the present study is to evaluate the evidence of cancer risks from such low-dose-rate, moderate-dose (LDRMD) exposures. Our literature search for primary epidemiological studies on cancer incidence and mortality risks from LDRMD exposures included publications from 2002 to 2007, and an update of the UK National Registry for Radiation Workers study. For each (LDRMD) study we calculated the risk for the same types of cancer among the atomic bomb survivors with the same gender proportion and matched quantities for dose, mean age att…
Theory of Mind (ToM) and language: stimulating metalinguistic skills in people with dementia
2016
ABSTRACT Purpose The purpose of this paper was to assess the use of the Metalinguistic Skills Stimulation Program in Theory of Mind (ToM) in people with dementia. Methods An experimental research design was developed. Forty-two subjects, 28 women and 14 men, aged 61 to 87 participated in the study. The three following groups were created: Experimental Group and Control Group - both composed of people with dementia, and Normal Group - consisting of people without dementia or any medical and psychological disorders that keep them from living a normal life. All subjects in the sample were evaluated using the MMSE30 Test and the MetAphAs Test. The stimulation program was used with the Experimen…
Growth and sustainability of agricultural systems: the case of Sicilian wine-growing farms
2016
International audience; The Sicilian wine-growing sector is characterised by the presence on the one hand of many small enterprises that limit their activity to the first stage of the supply chain (field production) and on the other of few enterprises that adopt a strategy of total vertical integration, from the production to the sale of wine. The first group of enterprises operates in a competitive market and in many cases with marginal revenues that are lower than marginal costs, leading entrepreneurs to abandon the activity of grape production. The second group operates in an oligopolistic market and it is able to compete in an international market. Findings reveal that competitive advan…
Growth dynamics and space in Brazil
2003
The authors bring together two strands of the empirical literature and analyze the geography of the regional economic performance of the states of the Brazilian Federation from 1939 to 1998. Using tools from spatial statistics, they examine the spatial dependence of regional per capita income in Brazil during the past six decades. They also examine the role of geography in explaining economic growth patterns using intradistribution dynamic tools based on Markov transition matrices and stochastic kernels in a discrete and a continuous framework. The analyses reveal the existence of two spatial clusters in Brazil, a low-income cluster in the northeast and a high-income cluster in the southea…
Building on precarious knowledge: The governing of family formation through matching practice in transnational adoption
2018
This article explores matching as a psycho-pedagogical technology of child placement in transnational adoption. Drawing on empirical data and theoretical linkages to governmentality and biopolitics...
Urban Sprawl and Northern European Residential Tourism in the Spanish Mediterranean Coast
2016
Residential tourism from Northern European countries has influenced the process of urban development in the Spanish Mediterranean coast. We explain the recent urban growth in Spain (or “Spanish house bubble”) and then show the main characteristics of the influx of citizens from other European countries richer than Spain, especially into the Spanish Mediterranean coast and specifically into the Costa Blanca region. Finally we demonstrate the relationship between the development of residential tourism and the growth of urban sprawl in the Spanish Mediterranean coast and we analyze some of its consequences for the region..
Soil erosion processes in subtropical plantations ( Diospyros kaki ) managed under flood irrigation in Eastern Spain
2019
Persimmons (Diospyros kaki) are trees cultivated under subtropical environmental conditions but are also found in other regions such as the Mediterranean. However, no research has been conducted to investigate soil erosion processes under Mediterranean soil management systems characterized by flood irrigation and/or tillage. The Improved Stock Unearthing Method (ISUM) for assessing long-term soil mobilization was applied to two fields, one under tillage and the other under no-till with herbicide within a 25-year old Mediterranean persimmon plantation. Replicating methods used in vineyard studies, graft unions on persimmon plants were used as passive bio-indicators of soil surface changes in…