Search results for "53"
showing 10 items of 2908 documents
David Rosenthal’s Tirant lo Blanc turns 30
2014
The groundbreaking English language translation of Tirant lo Blanc by New York poet and academic David Rosenthal remains dominant three decades after its initial, and celebrated, release. Rosenthal’s controversially fluid and concise rendering of the Valencian classic survived a serious challenge 20 years ago by a more literal version from a well-meaning amateur translator and journeyman academic backed by a leading U.S.-based Catalan scholar. The article reviews the controversy and compares the two versions, adding comments from some of the key critics. La traducció capdavantera a l’anglés del Tirant lo Blanc, feta pel poeta i erudit de Nova York, David Rosenthal, continua mantenint la seu…
Mans mnemòniques en l’Ars demonstrativa de Ramon Llull
2014
Aquest article recupera el concepte d’art de la memòria aplicat a les obres de Ramon Llull a partir de la presentació i el comentari de figures de mans amb finalitats mnemotècniques, especulatives i predicadores, que es troben en els manuscrits lul·lians de l’Ars demonstrativa –escrita el 1283– datats del segle xiii i el xvi. En els manuscrits de Venècia (Bibl. Marciana, Lat. VI. 200), de Bèrgam (MA 365) i de San Candido (B. della Collegiata, VIII C.8), la mà està vinculada a la figura S de l’Ars demonstrativa. En el ms &.IV.6 de l’Escorial, en canvi, la mà representa la figura A. El precedent més rellevant d’aquesta iconografia manual és la mà guidoniana, en l’àmbit musical, juntament amb …
MYC Activates Stem-like Cell Potential in Hepatocarcinoma by a p53-Dependent Mechanism
2014
Activation of c-MYC is an oncogenic hallmark of many cancers including liver cancer, and is associated with a variety of adverse prognostic characteristics. Despite a causative role during malignant transformation and progression in hepatocarcinogenesis, consequences of c-MYC activation for the biology of hepatic cancer stem cells (CSCs) are undefined. Here, distinct levels of c-MYC over-expression were established by using two dose-dependent tetracycline inducible systems in 4 hepatoma cell lines with different p53 mutational status. The CSCs were evaluated using side-population approach as well as standard in vitro and in vivo assays. Functional repression of p53 was achieved by lentivira…
Cytotoxicity of the bisphenolic honokiol from Magnolia officinalis against multiple drug-resistant tumor cells as determined by pharmacogenomics and …
2014
A main problem in oncology is the development of drug-resistance. Some plant-derived lignans are established in cancer therapy, e.g. the semisynthetic epipodophyllotoxins etoposide and teniposide. Their activity is, unfortunately, hampered by the ATP-binding cassette (ABC) efflux transporter, P-glycoprotein. Here, we investigated the bisphenolic honokiol derived from Magnolia officinalis. P-glycoprotein-overexpressing CEM/ADR5000 cells were not cross-resistant to honokiol, but MDA-MB-231 BRCP cells transfected with another ABC-transporter, BCRP, revealed 3-fold resistance. Further drug resistance mechanisms analyzed study was the tumor suppressor TP53 and the epidermal growth factor recepto…
Modelling, Identification and Control of a 5-DOF Shotcrete Robot : Development of a Framework for Automatic Application of Shotcrete for AMV 4200H
2019
Master's thesis Mechatronics MAS500 - University of Agder 2019 Today, process automation is the primary area of development in the shotcrete industry. Automaticshotcrete operations can yield an increase in operational efficiency and personnel safety as well asreductions in cost and environmental impact. This thesis develops a framework for automaticapplication of shotcrete using the AMV 4200H and provides an automatic spraying mode usinginteroceptive sensing. The shotcrete vehicle is equipped with a five degrees-of-freedom manipulatorand is currently operated manually. Our contributions include solving the forward kinematicsthrough the Denavit-Hartenberg convention, and the inverse kinemati…
Modelling soil organic carbon stocks in global change scenarios: a CarboSOIL application
2013
Abstract. Global climate change, as a consequence of the increasing levels of atmospheric CO2 concentration, may significantly affect both soil organic C storage and soil capacity for C sequestration. CarboSOIL is an empirical model based on regression techniques and developed as a geographical information system tool to predict soil organic carbon (SOC) contents at different depths. This model is a new component of the agro-ecological decision support system for land evaluation MicroLEIS, which assists decision-makers in facing specific agro-ecological problems, particularly in Mediterranean regions. In this study, the CarboSOIL model was used to study the effects of climate change on SOC …
Nouvelles perspectives concernant la structure et la fonction du domaine carboxyl terminal de Hfq
2015
Accumulating evidence indicates that RNA metabolism components assemble into supramolecular cellular structures to mediate functional compartmentalization within the cytoplasmic membrane of the bacterial cell. This cellular compartmentalization could play important roles in the processes of RNA degradation and maturation. These components include Hfq, the RNA chaperone protein, which is involved in the post-transcriptional control of protein synthesis mainly by the virtue of its interactions with several small regulatory ncRNAs (sRNA). The Escherichia coli Hfq is structurally organized into two domains. An N-terminal domain that folds as strongly bent β-sheets within individual protomers to…
Utvikling av verdikjeden oppstrøms for Trebyggeriet AS
2003
Hovedoppgave i Industriell økonomi og informasjonsledelse, Høgskolen i Agder, Grimstad Vi har i denne oppgaven sett på muligheten til å utvikle verdikjeden oppstrøms for en produsent av trekonstruksjoner. Trebyggeriet AS er en nyetablert bedrift lokalisert på Kjetså i Evje og Hornnes kommune. I produksjonen benyttes en datastyrt pre-cut maskin til å forme trelasten. Dette er en teknologi som ikke har vært benyttet før i Norge, men som har utviklet seg over en 10 – 15 års periode i Mellom-Europa. For å oppnå en effektiv vareflyt og minimale mengder avkapp av materialene kreves det andre egenskaper ved leveransene enn det som er vanlig i Norge i dag. I Tyskland, hvor denne teknologien har vær…
En studie av fagarbeiderens informasjonsbehov på byggeplass : En kvalitativ casestudie
2018
Masteroppgave industriell økonomi og teknologiledelse IND590 - Universitetet i Agder 2018 Kontekst: Veidekke Agder bygger videregående skole i Tvedestrand, hvor det er gjort innkjøp av digitale verktøy som kan formidle informasjon til og fra fagarbeideren. Oppgaven omhandler gjennomføringen av en casestudie med utgangspunkt i lean-filosofi. Hensikten er at forutsetningene rundt skal effektiviseres og ikke fagarbeideren. Forskeren ønsker derfor å se hvordan fagarbeideren kan få sitt informasjonsbehov dekket, samtidig som at informasjonen ikke møter hindringer til og fra fagarbeideren. Metode: Det er blitt utført en kvalitativ casestudie, hvor data er blitt hentet gjennom Veidekke sine aktøre…
Integrated project delivery (IPD) in Norwegian construction projects : Sharing of risk and opportunities aiming at better cooperation and project ach…
2018
Master's thesis Industrial Economics and Technology Management IND590 - University of Agder 2018 In the architecture, engineering and construction (AEC) industry projects are often temporary in nature and are often characterised as PBO project-based organisations. Each project chooses a number of strategies which makes up a project development model. Traditionally models have focused on transactional contracting between actors in the value chain which opens up the way, for sub-optimisation and risk aversion as the common challenges. In such circumstances, each actor has a different perception of the aim and the success of the project, and so try to find ways to take the lowest risk and gain…