Search results for "53"
showing 10 items of 2908 documents
The apoptotic effects and synergistic interaction of sodium butyrate and MG132 in human retinoblastoma Y79 cells
1999
This study deals with the apoptotic effect exerted on human retinoblastoma Y79 cells by both sodium butyrate and an inhibitor of 26S proteasome [z-Leu-Leu-Leu-CHO (MG132)] and their synergistic effect. Exposure to sodium butyrate (1-4 mM) induced an accumulation of cells in the G2-M phase that was already visible after 24 h of treatment, when morphological and biochemical signs of apoptosis appeared only in a small number of cells (5-10%). Thereafter, the apoptotic effects increased progressively with slow kinetics, reaching a maximum after 72 h of exposure, when they concerned a large fraction of cells (>75% with 4 mM sodium butyrate). Sodium butyrate stimulated the conversion of procaspas…
The analysis of the concept of vulnerability on the International legal framework on Human Trade
2018
The establishment of the Trafficking1 and the Smuggling Protocol2 has brought to the surface the importance of the concept of vulnerability. However, the Protocols have not given a precise definition to the concept of vulnerability, in order to perceive a practical application on legal grounds. In 2005, the Council of Europe tries to delimit the definition’s gap of such concept, through the Convention of Warsaw3, giving a more exact definition of the concept. The present article intends to analyse the evolution and the application of this concept on the international legal framework on Human trafficking and Smuggling of migrants.
Molecular dynamics studies on Mdm2 complexes: An analysis of the inhibitor influence
2012
p53 is a powerful anti-tumoral molecule frequently inactivated by mutations or deletions in cancer. However, half of all human tumors expresses wild-type p53, and its activation, by antagonizing its negative regulator Mdm2, might offer a new strategy for therapeutic protocol. In this work, we present a molecular dynamics study on Mdm2 structure bound to two different known inhibitors with the aim to investigate the structural transitions between apo-Mdm2 and Mdm2-inhibitor complexes. We tried to gain information about conformational changes binding a benzodiazepine derivative inhibitor with respect the known nutlin and the apo form. The conformational changes alter the size of the cleft and…
Search for new particles in two-jet final states in 7 TeV proton-proton collisions with the ATLAS detector at the LHC
2010
19 páginas, 2 figuras, 1 tabla.-- et al.(ATLAS Collaboration).
A parts-per-billion measurement of the antiproton magnetic moment
2017
The magnetic moment of the antiproton is measured at the parts-per-billion level, improving on previous measurements by a factor of about 350. Comparing the fundamental properties of normal-matter particles with their antimatter counterparts tests charge–parity–time (CPT) invariance, which is an important part of the standard model of particle physics. Many properties have been measured to the parts-per-billion level of uncertainty, but the magnetic moment of the antiproton has not. Christian Smorra and colleagues have now done so, and report that it is −2.7928473441 ± 0.0000000042 in units of the nuclear magneton. This is consistent with the magnetic moment of the proton, 2.792847350 ± 0.0…
Antiproton over proton and K$^-$ over K$^+$ multiplicity ratios at high $z$ in DIS
2020
The $\bar{\rm p} $ over p multiplicity ratio is measured in deep-inelastic scattering for the first time using (anti-) protons carrying a large fraction of the virtual-photon energy, $z>0.5$. The data were obtained by the COMPASS Collaboration using a 160 GeV muon beam impinging on an isoscalar $^6$LiD target. The regime of deep-inelastic scattering is ensured by requiring $Q^2$ > 1 (GeV/$c$)$^2$ for the photon virtuality and $W > 5$ GeV/$c^2$ for the invariant mass of the produced hadronic system. The range in Bjorken-$x$ is restricted to $0.01 < x < 0.40$. Protons and antiprotons are identified in the momentum range $20 ��60$ GeV/$c$. In the whole studied $z$-region, the $\…
Measurement of multi-jet cross sections in proton-proton collisions at a 7 TeV center-of-mass energy
2011
Inclusive multi-jet production is studied in proton–proton collisions at a center-of-mass energy of 7 TeV, using the ATLAS detector. The data sample corresponds to an integrated luminosity of 2.4 pb−1. Results on multi-jet cross sections are presented and compared to both leading-order plus parton-shower Monte Carlo predictions and to next-to-leading-order QCD calculations.
Measurement of the Charge-Averaged Elastic Lepton-Proton Scattering Cross Section by the OLYMPUS Experiment
2020
Physical review letters 126(16), 162501 (1-6) (2021). doi:10.1103/PhysRevLett.126.162501
Measurement of proton electromagnetic form factors in the time-like region using initial state radiation at BESIII
2021
Physics letters / B 817, 136328 (2021). doi:10.1016/j.physletb.2021.136328
Conflicts over the provision and payment of wages of the "pavordías" of the University of Valencia during the second half of the seventeenth century
2002
Este artículo analiza las causas que influyeron en la dificultad de dotar las pavordías de la Universidad de Valencia en la segunda mitad del seiscientos. Los incrementos salariales de los pavordes, los gastos provocados por los continuos pleitos con los canónigos, la disminución de la renta de la pavordía, la reclamación por la Cámara Apostólica de los quindenios correspondientes y el desacuerdo entre la Ciudad y los pavordes respecto al estado de las cuentas se conjugaron para provocar la paralización de la provisión de preposituras. Situación a la que sólo la firma de las sucesivas concordias de 1669 y 1680 entre la Ciudad y los pavordes consiguió poner fin. This article analyzes the cau…