Search results for "53"
showing 10 items of 2908 documents
High-resolution, accurate multiple-reflection time-of-flight mass spectrometry for short-lived, exotic nuclei of a few events in their ground and low…
2019
Physical review / C covering nuclear physics 99(6), 064313 (2019). doi:10.1103/PhysRevC.99.064313
Studi di dinamica molecolare su Mdm2 legata a due differenti inibitori
2009
MOLECULAR DYNAMICS AND DOCKING IN THE STUDY OF NEW INHIBITORS OF MDM2-p53 INTERACTION
2008
Fundamental bounds on qubit reset
2020
Qubit reset is a basic prerequisite for operating quantum devices, requiring the export of entropy. The fastest and most accurate way to reset a qubit is obtained by coupling the qubit to an ancilla on demand. Here, we derive fundamental bounds on qubit reset in terms of maximum fidelity and minimum time, assuming control over the qubit and no control over the ancilla. Using the Cartan decomposition of the Lie algebra of qubit plus two-level ancilla, we identify the types of interaction and controls for which the qubit can be purified. For these configurations, we show that a time-optimal protocol consists of purity exchange between qubit and ancilla brought into resonance, where the maximu…
Succesio ab intestato: Concerning the death of Rodrigo de Mendoza, I Marquis of the Cenete
2017
La muerte de Rodrigo de Mendoza, I marqués del Cenete, sin testamento se vio envuelta de la incertidumbre propia del fallecimiento de un noble con un cuantioso patrimonio heredado en gran parte de su padre, el gran cardenal de España, sin especificar ni repartir y con tres hijas menores huérfanas sin un albacea designado por él. El gobernador general de Valencia, Lluís de Cabanyelles, del círculo más íntimo del marqués durante su estancia en la ciudad del Turia, junto a otros partícipes y testigos, impulsó el proceso de inventariado de todos sus bienes cuatro días después de su defunción, apelando, asimismo, al emperador Carlos V para que confirmase al virrey del reino de Valencia y hermano…
Garrido Mayol, Vicente: Las garantías del procedimiento prelegislativo: la elaboración y aprobación de los proyectos de ley
2010
Recensión sobre la obra: GARRIDO MAYOL, Vicente: Las garantías del procedimiento prelegislativo: la elaboración y aprobación de los proyectos de ley. Tirant lo Blanch, Valencia, 2010, 336 pp.
Current advancement in immunosensing of p53 tumor suppressor protein based on nanomaterials: Analytical approach
2017
Abstract The utility of detection of p53 in tomorrow's personalized health care field will mean early and accurate diagnosis of many types of cancers. This review is meant to provide an overview of the various types of immunosensors and immunoassay have been developed for determination of p53, along with significant advances over the last several years in related technologies. In addition, this review described: • Most frequently applied principles in immunoassay/immunosensing of p53. • The aspects of fabrication in the perspective of immunoassay/immunosensing applications. • The potential of various electrochemical, electrochemiluminescence immunosensors for the determination of p53 within…
Synergistic cytotoxic interactions between sodium butyrate, MG132 and camptothecin in human retinoblastoma Y79 cells.
2000
This paper studies the effects caused in human retinoblastoma Y79 cells by treatment with combinations of sodium butyrate, the inhibitor of topoisomerase I camptothecin and the inhibitor of 26S proteasome MG132. The combination of sodium butyrate and camptothecin resulted in a strong synergistic cytotoxicity, as revealed by combination indices of 0.77 and 0.52 calculated at IC(50) and IC(75). Synergistic interactions were also demonstrated for combinations of sodium butyrate and MG132, camptothecin and MG132 and for a combination of all three compounds. The cytotoxic effects observed after the combined treatments can be considered a consequence of apoptosis, as suggested by the appearance o…
Structural, Thermodynamic, and Kinetic Traits of Antiestrogen-Compounds Selectively Targeting the Y537S Mutant Estrogen Receptor α Transcriptional Ac…
2019
The most frequently diagnosed cancers in women are the estrogen receptor (ER)-positive breast cancer subtypes, which are characterized by estrogen dependency for their growth. The mainstay of clinical treatment for this tumor relies on the modulation of ER action or on the suppression of estrogen biosynthesis via the administration of Selective ERα Modulators/Down-regulators (SERMs/SERDs) or aromatase inhibitors, respectively. Nevertheless, de novo and acquired resistance to these therapies frequently occurs and represents a major clinical concern for patient survival. Recently, somatic mutations affecting the hormone-binding domain of ERα (i. e. Y537S, Y537N, D538G) have been associated w…
p53 Involvement in the control of murine hair follicle regression.
2001
p53 is a transcription factor mediating a variety of biological responses including apoptotic cell death. p53 was recently shown to control apoptosis in the hair follicle induced by ionizing radiation and chemotherapy, but its role in the apoptosis-driven physiological hair follicle regression (catagen) remains to be elucidated. Here, we show that p53 protein is strongly expressed and co-localized with apoptotic markers in the regressing hair follicle compartments during catagen. In contrast to wild-type mice, p53 knockout mice show significant retardation of catagen accompanied by significant decrease in the number of apoptotic cells in the hair matrix. Furthermore, p53 null hair follicles…