Search results for "53"
showing 10 items of 2908 documents
Design, Synthesis, Chemical and Biochemical Insights Into Novel Hybrid Spirooxindole-Based p53-MDM2 Inhibitors With Potential Bcl2 Signaling Attenuat…
2021
The tumor resistance to p53 activators posed a clinical challenge. Combination studies disclosed that concomitant administration of Bcl2 inhibitors can sensitize the tumor cells and induce apoptosis. In this study, we utilized a rapid synthetic route to synthesize two novel hybrid spirooxindole-based p53-MDM2 inhibitors endowed with Bcl2 signaling attenuation. The adducts mimic the thematic features of the chemically stable potent spiro [3H-indole-3,2′-pyrrolidin]-2(1H)-ones p53-MDM2 inhibitors, while installing a pyrrole ring via a carbonyl spacer inspired by the natural marine or synthetic products that efficiently inhibit Bcl2 family functions. A chemical insight into the two synthesized…
Association between socioeconomic factors and origin of hospital referrals among patients with oral cancer.
2022
The Brazilian Unified Health System (SUS) is responsible for offering free assistance to more than 100 million Brazilians, including treatment of oral cancer lesions. Considering that the Brazilian public system aids the most vulnerable population, this study analyzed whether the origin of hospital referrals of patients with oral cancer is associated with socioeconomic factors. A cross-sectional study was carried out from cancer hospital records of the National Cancer Institute (RHC-INCA), considering the primary locations (C00 to C06) diagnosed between 2016 and 2019. Data on gender, skin color (white and non-white), education (no schooling, incomplete or complete elementary education; high…
Interactions of membranes with coarse-grain proteins: a comparison
2012
We study the interactions between lipid bilayers and rigid transmembrane proteins by Monte Carlo simulations of generic coarse-grain models. Different popular protein models are considered and compared with each other, and key parameters such as the hydrophobicity and the hydrophobic mismatch are varied systematically. Furthermore, the properties of the membrane are manipulated by applying different tensions. The response of the membrane to the insertion of single proteins is found to be mostly generic and independent of the choice of the protein model. Likewise, the orientational distributions of single proteins depend mainly on the hydrophobic mismatch and the hydrophobicity of the protei…
Testing the nature of the Λ(1520)-resonance in proton-induced production
2006
The $\Lambda(1520)$ resonance has been recently studied in a unitarized coupled channel formalism with $\pi\Sigma(1385)$, $K\Xi(1530)$, $\bar{K}N$ and $\pi\Sigma$ as constituents blocks. We provide a theoretical study of the predictions of this model in physical observables of the $pp\to pK^+K^-p$ and $pp\to pK^+\pi^0\pi^0\Lambda$ reactions. In particular, we show that the ratio between the $\pi^0\pi^0\Lambda$ and $K^-p$ mass distributions can provide valuable information on the ratio of the couplings of the $\Lambda(1520)$ resonance to $\pi\Sigma(1385)$ and $\bar{K}N$ that the theory predicts. Calculations are done for energies which are accessible in an experimental facility like COSY at …
Antecedentes y efectos del apego a la marca: papel moderador del posicionamiento de marca por atributo preeminente y de la implicación en la categorí…
2017
Cada día estamos expuestos a mayor cantidad de marcas, pocas sobresalen y menos aún generan apego emocional en sus usuarios. Aquellas que logran generar el apego emocional de sus consumidores, se benefician no solamente en cuanto a preferencia, lealtad y recompra, sino además en recomendaciones positivas, disposición a pagar un valor más alto por sus consumidores para poseerlas, y hasta tolerancia mayor con errores que la marca puede cometer. En este marco, la presente tesis persigue tres objetivos: (i) Explorar el impacto que cuatro antecedentes (personalidad de la marca, calidad percibida, notoriedad de marca y credibilidad de marca) y tres efectos (lealtad, intención de compra y riesgo p…
Study of very forward energy and its correlation with particle production at midrapidity in pp and p-Pb collisions at the LHC
2022
Journal of high energy physics 08(8), 86 (2022). doi:10.1007/JHEP08(2022)086
Hard x-ray photoelectron spectroscopy: a snapshot of the state-of-the-art in 2020
2021
Journal of physics / Condensed matter 33(23), 233001 (1-44) (2021). doi:10.1088/1361-648X/abeacd
De participació local. Una proposta metodològica desde la investigació-acció-participativa
2018
Citizen participation is an increasingly prevalent term in our society. In the process of deployment in the municipal area, progressively local corporations make efforts to innovate practices and develop experiences of citizen participation in defining policies and public affairs, and allocating budgets. While innovation has been advanced with regard to the tools and mechanisms to be used to promote participation, many of the initiatives and experiences have focused more on the implementation of the vote than in the different social processes inherent in the participation. Moreover, we are faced with the absence of a methodological guide that allows approaching a project or strategic plan o…
Plasma-wall interaction studies within the EUROfusion consortium: Progress on plasma-facing components development and qualification
2017
This work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014-2018 under grant agreement No 633053. The views and opinions expressed herein do not necessarily reflect those of the European Commission.
«Cual doctora en cielo graduada...». The feminine poetry for literary contests in honor of the beatification and canonization of Teresa of Ávila (Val…
2015
L’objectiu d’aquest estudi és examinar les composicions poètiques aportades per dones als tres certàmens celebrats a València i Barcelona, amb motiu de la beatificació (1614) i posterior canonització (1622) de Teresa de Jesús; dos moments clau per a la consolidació de la fama de la carmelitana avilesa que van possibilitar l’exhibició pública i impressió de poesia femenina. Analitzem també la participació femenina catalana al certamen celebrat a Saragossa el 1614 per la beatificació. L’estudi està enfocat des d’una perspectiva femenina, a través de la revisió de dihuit poesies amb signatura de dones que ens han transmès les extenses relacions impreses. Al llarg del comentari dels poemes, ana…