Search results for "53"

Telomere Shortening in Neural Stem Cells Disrupts Neuronal Differentiation and Neuritogenesis

2009

Proliferation in the subependymal zone (SEZ) and neurogenesis in the olfactory bulb decline in the forebrain of telomerase-deficient mice. The present work reveals additional effects of telomere shortening on neuronal differentiation, as adult multipotent progenitors with critically short telomeres yield reduced numbers of neurons that, furthermore, exhibit underdeveloped neuritic arbors. Genetic data indicate that the tumor suppressor protein p53 not only mediates the adverse effects of telomere attrition on proliferation and self-renewal but it is also involved in preventing normal neuronal differentiation of adult progenitors with dysfunctional telomeres. Interestingly, progenitor cells …

Recio Morales, Oscar: Alejandro O'Reilly, inspector general. Poder militar, familia y territorio en el reinado de Carlos III

2021

Vēsture: Latvijas Universitātes Žurnāls, 2018, Nr.6

2019

Search for neutral MSSM Higgs bosons at LEP

2006

The four LEP collaborations, ALEPH, DELPHI, L3 and OPAL, have searched for the neutral Higgs bosons which are predicted by the Minimal Supersymmetric Standard Model (MSSM). The data of the four collaborations are statistically combined and examined for their consistency with the background hypothesis and with a possible Higgs boson signal. The combined LEP data show no significant excess of events which would indicate the production of Higgs bosons. The search results are used to set upper bounds on the cross-sections of various Higgs-like event topologies. The results are interpreted within the MSSM in a number of "benchmark" models, including CP-conserving and CP-violating scenarios. Thes…

Nimfes al Vinalopó. La poesia renaixentista d’un alacantí oblidat, Josep Gosalbes de Cunedo (s. XVI)

2013

Resum: L’obra del poeta alacantí del segle XVI Josep Gosalbes de Cunedo ha passat a l’oblit. Alguns aspectes de la seua vida i obra mereixen atenció, com a mínim, per haver tractat temes propis de la seua terra. Alguns dels seus poemes tracten l’antiga Governació d’Oriola, al sud del regne de València, i celebren la creació del bisbat d’Oriola, motiu pel qual l’autor descriu el territori amb gust renaixentista. La seua amistat amb l’humanista Just Lipsi marca la seua biografia, on guerres i presó també estan presents.Paraules clau: poesia llatina; Renaixement; Oriola; Alacant; Just LipsiAbstract: The work of the 16th. century poet from Alicante Joseph Gosalbes of Cunedo has been forgotten. …

Instrucció, 1753, 05, 30

Precedeix al tit.: [creu de Malta Signat al final: "Don Juan Antonio Bringas de la Torre" y rùbrica ms Port. amb orla xil Escut reial xil. a la port Caplletra ornada en la primera p Sign.: [A]-F2 Fules impreses per ambdues cares Reclams

Primary mouse fibroblasts deficient for c-Fos, p53 or for both proteins are hypersensitive to UV light and alkylating agent-induced chromosomal break…

2000

The important regulatory proteins, c-Fos and p53 are induced by exposure of cells to a variety of DNA damaging agents. To investigate their role in cellular defense against genotoxic compounds, we comparatively analysed chromosomal aberrations and apoptosis induced by ultraviolet (UV-C) light and the potent alkylating agent methyl methanesulfonate (MMS) in primary diploid mouse fibroblasts knockout for either c-Fos or p53, or double knockout for both genes. We show that c-Fos and p53 deficient fibroblasts are more sensitive than the corresponding wild-type cells as to the induction of chromosomal aberrations and apoptosis. Double knockout fibroblasts lacking both c-Fos and p53 are viable an…

Studi greci e latini nell?antica Università di Altamura (1748-1821)

2019

The article tries to highlight, despite the scarse of available documentation, the Greek and Latin studies (language and texts) in the ancient Apulian University in Altamura (1748-1821). Furthermore, on the basis of unpublished archival materials (school registers and student workbooks) it is possible to shed light on the ancient authors explained at school, the teaching methods, and the study practices.

Inuentiones y translationes de S. Mercurio

2019

Inuentiones and translationes of the relics are part of the hagiographic dossier of a saint and provide interesting information about his cult over the centuries. For S. Mercurius of Caesarea the original texts in Greek have been lost, but we have two collections miracles in Coptic that narrate the inuentio and translatio of his relics and there is also a medieval tradition about his translatio to Benevento (Italy). From all these texts is deduced a healing cult of S. Mercurius based on the usual topics.

Induction of apoptosis in human retinoblastoma cells by topoisomerase inhibitors

1998

PURPOSE:To examine the apoptotic effect induced in human retinoblastoma Y79 cells by camptothecin, etoposide, and amsacrine, to examine the effect of these drugs on the expression of many apoptosis-related modulators, and to test the antiapoptotic effect exerted by insulin-like growth factor-I (IGF-I). METHODS:Morphologic features of apoptosis were demonstrated using acridine orange- ethidium bromide staining and electron microscopy. DNA fragmentation was determined by means of an in situ cell detection procedure (TdT-dUTP terminal nick-end labeling [TUNEL]) or by electrophoresis on agarose gels and was quantified by enzyme-linked immunosorbent assay. The expression of apoptosis-related mod…