Search results for "54"
showing 10 items of 2200 documents
Hypoxia-inducible factor 1 alpha expression increases during colorectal carcinogenesis and tumor progression
2008
Abstract Background Hypoxia-inducible factor 1 alpha (HIF-1α) is involved in processes promoting carcinogenesis of many tumors. However, its role in the development of colorectal cancer is unknown. To investigate the significance of HIF-1α during colorectal carcinogenesis and progression we examined its expression in precursor lesions constituting the conventional and serrated pathways, as well as in non-metastatic and metastatic adenocarcinomas. Methods Immunohistochemistry and Western blot is used to analyse HIF-1α expression in normal colonic mucosa, hyperplastic polyps (HPP), sessile serrated adenomas (SSA), low-grade (TA-LGD) and high-grade (TA-HGD) traditional adenomas as well as in n…
A comparison between the chemical behaviour of lead-gold and lead-bismuth eutectics towards 316L stainless steel
2013
Radiochimica acta, 101 (10)
La Dánae burlesca de Pedro Silvestre. Edición anotada / The burlesque Danae by Pedro Silvestre. An annotated edition
2017
Ofrecemos en el presente trabajo la edición de un poema basado en el mito de Dánae que fue compuesto en el siglo XVIII por un autor que firmaba bajo el seudónimo de Pedro Silvestre. El mayor interés de esta composición radica en el hecho de ser una de las escasas muestras que encontramos en la literatura española de una fábula burlesca que desarrolla este mito clásico. Nuestro trabajo ofrece la transcripción modernizada –basada en el único manuscrito existente– de este texto hasta ahora inédito, además de una breve introducción y diversas notas lingüísticas y aclaratorias.Palabras clave: mitología, Dánae y Perseo, fábula burlesca, manuscrito, Pedro Silvestre. Abstract:We offer in this paper…
Perseo en la Comedia tardobarroca: Ignacio Ferrera y Pasqual
2015
Entre los géneros que recrearon el mito de Perseo en la literatura española sobresale la comedia barroca. Lope y Calderón compusieron dos conocidas obras sobre este asunto mitológico, que llegaría a su máxima expresión dramática con el auto sacramental Perseo y Andrómeda del propio Calderón. Sin embargo, ya casi mediado el siglo xviii, es decir, en el tardobarroco, encontramos una curiosa obra debida a un cierto Ignacio Ferrera y Pasqual, que constituye una de las versiones más sui generis de la historia de Perseo. Presentamos en este artículo un análisis de esta sorprendente pieza. Perseus in the late baroque comedy: Ignacio Ferrera y PasqualAbstract: Among the genres that recreated the m…
Pasaules spogulis
1599
Teoloģiski, filozofiski ētisks un vēsturisks traktāts, viens no apjomīgākajiem N. Molllīna iespieddarbiem. Izdots arī latīņu valodā (1588, 1599). Vācu valodas izdevums dāvāts Livonijas karavadonim dažādu valstu karadienestā Georgam Fārensbaham (1551-1602), Cēsu pirmajam vaivadam no 1598. gada līdz 1602. gadam, kad krita karā pret zviedriem aplencot Vīlandes pili. Grāmatas titullapu ietver ornamentāla aproce ar dažādām fantastiskām būtnēm, grifiem, jūras vāravām utml. Ievadā publicēta Dāvida Hilhena vēstule Georgam Cīgleram. Tad seko Dāniela Hermaņa sacerētais Georga Fārensbaha dzīves apraksts. Šis G. Cīglera darbs ir vienīgais Mollīna iespieddarbs, kas guvis plašāku ievērību ārpus Livonijas…
A Comparative Facebook Content Analysis between Romanian and Western European Airline Carriers
2014
This research aims to investigate the different social media strategies adopted by the airline companies from two European regions. In the attempt to land more customers on their social media runway, drive more sales from social media content, increase customer satisfaction through a high response rate or increase their brand awareness, the airlines combine creativity and high-quality ideas to better promote their products and services to customers all around the globe. The paper analyses the content (number of fans, posts, number of likes, the dynamics of comments, response rate) on the Facebook pages of Tarom, Blue Air, Wizz Air, Lufthansa, Austrian Airlines, KLM International and Air Eur…
Sphingosine-1-phosphate increases human alveolar epithelial IL-8 secretion, proliferation and neutrophil chemotaxis
2009
Sphingosine-1-phosphate (S1P) has been presented recently as a pro-inflammatory agent in the airway epithelium since S1P levels are increased in bronchoalveolar lavage fluid of human asthmatics. However, the effects of S1P over the alveolar epithelium and neutrophil interactions are poorly understood. Here, we show that S1P increased interleukin 8 (IL-8) gene expression and protein secretion and proliferation in alveolar epithelial cells A549 at physiological concentrations (1 microM). At the same time, S1P increased intracellular Ca2+ concentration (potency 17.91 microM, measured by epifluorescence microscopy), phospholipase D (PLD) activity (measured by chemiluminiscence method) and extra…
Can PBDEs affect the pathophysiologic complex of epithelium in lung diseases?
2020
Brominated flame-retardant (BFRs) exposure promotes multiple adverse health outcomes involved in oxidative stress, inflammation, and tissues damage. We investigated BFR effects, known as polybrominated diphenyl ethers (PBDEs) (47, 99 and 209) in an air-liquid-interface (ALI) airway tissue derived from A549 cell line, and compared with ALI culture of primary human bronchial epithelial cells (pHBEC). The cells, exposed to PBDEs (47, 99 and 209) (0.01-1 mu M) for 24 h, were studied for IL-8, Muc5AC and Muc5B (mRNAs and proteins) production, as well as NOX-4 (mRNA) expression. Furthermore, we evaluated tight junction (TJ) integrity by Trans-Epithelial Electrical Resistance (TEER) measurements, …
Crystal Structures and Cytotoxicity of ent-Kaurane-Type Diterpenoids from Two Aspilia Species
2018
A phytochemical investigation of the roots of Aspilia pluriseta led to the isolation of ent-kaurane-type diterpenoids and additional phytochemicals (1⁻23). The structures of the isolated compounds were elucidated based on Nuclear Magnetic Resonance (NMR) spectroscopic and mass spectrometric analyses. The absolute configurations of seven of the ent-kaurane-type diterpenoids (3⁻6, 6b, 7 and 8) were determined by single crystal X-ray diffraction studies. Eleven of the compounds were also isolated from the roots and the aerial parts of Aspilia mossambicensis. The literature NMR assignments for compounds 1 and 5 were revised. In a cytotoxicity assay, 12α-methoxy-ent-kaur-9(11),1…
Measles virus enhances the expression of cellular immediate-early genes and DNA-binding of transcription factor AP-1 in lung epithelial A549 cells.
2002
In this work we investigated the effect of measles virus (MV) infection on the expression of immediate-early genes junB, c-jun and c-fos mRNA as well as AP-1 DNA-binding activity in the lung epithelial-like adenocarcinoma cell line A549. The transcription factor AP-1, which is a group of dimeric complexes of the Fos and Jun family proteins, is an important regulator in many cellular responses to different extracellular stimuli. Membrane cofactor protein CD46, which acts as a receptor for laboratory-adapted and vaccine strains of MV, has been reported to associate with beta1 integrin molecules, which are known to trigger signaling events and activate immediate-early genes. The expression of …