Search results for "54"
showing 10 items of 2200 documents
Land Snail Communities in Limestone Gorges from the Southern Part of the Metaliferi Mountains (Apuseni Mountains, Romania)
2018
Abstract This study focuses on terrestrial gastropod communities in a karst area, where the presence of water and the limestone generates favourable environment for land snails. Three limestone gorges were analysed located in the southeast of the Metaliferi Mountains. Four different habitats in three limestone gorges were analysed – Glodului, Cibului and Mada. A total of 42 species of land snails were identified. The terrestrial gastropod communities in the area are dominated by calciphile species, such as Granaria frumentum, Truncatellina cylindrica and Alopia bielzii madensis. The differences between the analysed habitats are not pronounced enough to be reflected in the structure of the s…
Endoplasmic Reticulum Stress and miRNA Impairment in Aging and Age-Related Diseases
2021
Aging is a physiological process defined by decreased cellular and tissue functions. Reduced capacity of protein degradation is one of the important hallmarks of aging that may lead to misfolded protein accumulation and progressive loss of function in organ systems. Recognition of unfolded/misfolded protein aggregates via endoplasmic reticulum (ER) stress sensors activates an adaptive mechanism, the unfolded protein response (UPR). The initial step of UPR is defined by chaperone enhancement, ribosomal translation suppression, and misfolded protein degradation, while prolonged ER stress triggers apoptosis. MicroRNAs (miRNAs) are non-coding RNAs affecting various signaling pathways through de…
Walking Stroop carpet: an innovative dual-task concept for detecting cognitive impairment
2013
A Perrochon,1,2,5 G Kemoun,1,2 E Watelain,3,4 A Berthoz51ISIS, Research Institute on Handicap and Aging, Paris; 2Université de Poitiers, Laboratoire Mobilité, Vieillissement et Exercice (MOVE), EA 6314, 3Université de Valenciennes, LAMIH, UMR CNRS 8201, 4Université Sud Toulon Var, HandiBio, EA 4322, La Garde, 5LPPA, UMR CNRS 7152, Collège de France, Paris, FranceBackground: Several studies have reported the potential value of the dual-task concept during locomotion in clinical evaluation because cognitive decline is strongly associated with gait abnormalities. However, current dual-task tests appear to be insufficient for early diagnosi…
Do testate amoebae communities recover in concordance with vegetation after restoration of drained peatlands?
2016
The environmental importance of peatlands has stimulated efforts to restore their specific ecosystem structure and functions. Monitoring and assessment of the ecological state of the peatland is fundamental in restoration programmes. Most studies have focused on the responses of vegetation and, to a lesser extent, on testate amoebae (TA). To our knowledge, none have investigated whether these two groups show concordance in the context of restoration of drained peatland. Here we assess community concordance between TA and vegetation in boreal peatlands belonging to four different land use management classes (natural, drained, restored 3–7 years ago, and restored 9–12 years ago). TA and veget…
Aportaciones al conocimiento de los mosquitos (Diptera, Culicidae) de alta montaña presentes en la Península Ibérica
2009
Several larval samplings of mosquitoes (Diptera, Culicidae) in different mountainous regions of the peninsular Spain were carried out. A total of 2796 specimens belonging to 18 species were collected, nevertheless the 72.5 % of these finds includes only three of them (Cx. hortensis hortensis, Cx. pipiens and Cs. longiareolata). The adaptation capacity to a varied typology of water bodies together with the marked multivoltinism that characterizes their biotic cycles are postulated as two of the principal reasons that explain their abundances. The altitudinal distribution as well as some information about the bioecology of all the species captured are also exposed.
Primera cita de Culex interrogator (Diptera: Culicidae) para la Hispaniola y actualización del listado de mosquitos de Jarabacoa, República Dominicana
2020
Desde que dio inicio el nuevo siglo, varios estudios sobre la culicidofauna de la Hispaniola han elevado el conocimiento de este grupo de artrópodos, muy relevantes desde el punto de vista médico y veterinario. En relación a la diversidad de la familia Culicidae, los hallazgos más recientes se han realizado en el municipio de Jarabacoa, República Dominicana. Con el objetivo de profundizar en la diversidad de los culícidos presentes en esta localidad montañosa de El Cibao, se procedió a la búsqueda de criaderos de mosquitos, sobre todo de origen natural, desde enero de 2018 hasta junio de 2019. La identificación de los especímenes se realizó mediante la utilización de lupa binocular y micros…
The Influence of Hedonic and Utilitarian Motivators on Likelihood to Buy a Tourism Package
2013
To fully understand the pattern of choice, it is important that any explanation of consumer behavior to be accompanied by a complete understanding of the interplay between a consumer’s functional goals and experiential preferences within the decision context. Consumer researchers have increasingly begun to investigate consumer choice based on distinctions that involve the purchase and consumption of goods for pleasure versus for more utilitarian and instrumental purposes. Consumers are often faced with these types of choices between hedonic and utilitarian alternatives that are at least partly driven by emotional desires rather than cold cognitive deliberations. This research approaches fac…
Buying Intentions Influenced by Various Determinants in Tourism
2014
Marketing has acquired a central role in tourism because it helps organizations to create value in transactions with buyers. Thus, this important area of any business process is used to educate consumers, to add value to their experience in tourism, and to seek new ways to reward loyalty through innovative schemes (e.g., programs for frequent travelers). This paper presents the examination of the responses of 154 tourists in relation to their intention to purchase a travel package and the factors that are usually decisive in the decision making process regarding tourism services, factors that could also create the loyalty that any tourism enterprise can create through marketing.
Practical Considerations for the Daratumumab Management in Portuguese Routine Clinical Practice: Recommendations From an Expert Panel of Hematologists
2022
The recent therapeutic progress in multiple myeloma (MM) has led to the introduction of novel and highly potent drug classes. Daratumumab was the first CD38-targeting antibody showing to be effective and safe in MM patients as monotherapy and in combination regimens, which led to its rapid implementation in clinical practice. Considering that treatment discontinuation for drug-related adverse events can impact patients’ quality of life and outcomes, the treatment decision should consider different factors and be weighted for each patient individually. Here, we aimed to guide clinicians using daratumumab treatment for MM by addressing practical real-world considerations based on an expert pa…
High Output Heart Failure in Multiple Myeloma: Pathogenetic Considerations.
2022
The high output heart failure is a clinical condition in which the systemic congestion is associated to a high output state, and it can be observed in a non-negligible percentage of hematological diseases, particularly in multiple myeloma, a condition in which the risk of adverse cardiovascular events may increase, with a worse prognosis for patients. For this reason, though an accurate literature search, we provided in this review a complete overview of different pathogenetic mechanisms responsible for high output heart failure in multiple myeloma. Indeed, this clinical finding is present in the 8% of multiple myeloma patients, and it may be caused by artero-venous shunts, enhanced angioge…