Search results for "54"
showing 10 items of 2200 documents
The literary dramatic text as a corpus for historical analysis of facework activities
2016
This paper aims to justify the use of theatre plays as valid corpus to characterize aspects of Spanish socio-cultural face, specifically the historical evolution of face work in Spanish. Literature works have not always been considered as valid corpus due to its fictional nature and stylistic purpose. However, this paper aims not only to refute these two arguments against the use of plays, but also to propose different arguments that support the use of this type of corpus. In fact, it is suggested that plays, may constitute data for pragmatic analysis because they present sociocultural implications, interactional development of the action, a wide range of communicative situations and psicop…
Fuzzy logic-decision-making system dedicated to evaluation of logistics project effectiveness
2016
Background: Project effectiveness is synonymous with project success. It is measured or assessed in terms of the degree to which project objectives are achieved. This paper presents an approach to evaluating the effectiveness of logistics projects. The starting point is the analysis of the current state of knowledge in the area of assessing project effectiveness, including logistics projects. The purpose of the study was to identify the critical factors determining the success of logistics projects and develop a model of logistics project effectiveness. Methods: The paper is based on the available recent scientific-theoretical research and publications and on practical studies in 25 enterpr…
Value of Combined PET Imaging with [18F]FDG and [68Ga]Ga-PSMA-11 in mCRPC Patients with Worsening Disease during [177Lu]Lu-PSMA-617 RLT
2021
Despite the promising results of prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) in metastatic castration-resistant prostate cancer (mCRPC), some patients show worsening disease during PSMA-RLT. We investigated the value of combined [18F]FDG and [68Ga]Ga-PSMA-11 PET imaging in this setting. In n = 29 mCRPC patients with worsening disease after a median of four cycles of [177Lu]Lu-PSMA-617 RLT, combined [18F]FDG and [68Ga]Ga-PSMA-11 PET imaging was performed to detect [18F]FDG-avid lesions with low or no PSMA expression (mismatch lesions). To evaluate prognostic implication of mismatch, survival analyses regarding presence, location, and [18F]FDG PET-derived para…
KOSMOS 2017 Peru Side Experiment: nutrients, phytoplankton abundances, enzyme rates, photophysiology
2022
This data was collected during an short-term incubation experiment in March 2017 that investigated the response of a surface plankton community to upwelling. This experiment was carried in the framework of the SFB754-funded KOSMOS mesocosm study that took place in La Punta, Callao, Peru between February-April 2017. A total of six different treatments were used to disentangle chemical and biological characteristics of deep water that influence surface plankton blooms: 2 different deep water sources with different nutrient concentrations; 3 treatments to distinguish the effects of inorganic nutrients, organic nutrients and deep water microbial populations. Measured variables include inorganic…
Structured reporting of rectal cancer staging and restaging: A consensus proposal
2021
Background: Structured reporting (SR) in oncologic imaging is becoming necessary and has recently been recognized by major scientific societies. The aim of this study was to build MRI-based structured reports for rectal cancer (RC) staging and restaging in order to provide clinicians all critical tumor information. Materials and Methods: A panel of radiologist experts in abdominal imaging, called the members of the Italian Society of Medical and Interventional Radiology, was established. The modified Delphi process was used to build the SR and to assess the level of agreement in all sections. The Cronbach’s alpha (Cα) correlation coefficient was used to assess the internal consistency of ea…
Oxidative and nitrosative stress in the metastatic microenvironment.
2010
Metastases that are resistant to conventional therapies are the main cause of most cancer-related deaths in humans. Tumor cell heterogeneity, which associates with genomic and phenotypic instability, represents a major problem for cancer therapy. Additional factors, such as the attack of immune cells or organ-specific microenvironments, also influence metastatic cell behavior and the response to therapy. Interaction of cancer and endothelial cells in capillary beds, involving mechanical contact and transient adhesion, is a critical step in the initiation of metastasis. This interaction initiates a cascade of activation pathways that involves cytokines, growth factors, bioactive lipids and r…
An ultra-short measure of positive and negative affect: The Reduced Affective Well-Being Scale (RAWS).
2020
In applied organizational research, where economy of scale is often a crucial factor in successful assessment, ultra-short measures are often needed. This study investigates the psychometric properties of the Reduced Affective Well-Being Scale (RAWS), an ultra-short measure of positive and negative affect in the workplace. This 6-item ultra-short version was compared with the original 12-item scale proposed by Segura and González-Romá (2003) in terms of internal consistency and criterion validity, using a sample of 1117 bank employees. In addition, longitudinal measurement invariance and within-subject reliability of the RAWS over time were assessed in a longitudinal sample of 458 employees…
Kinetics of Renal Function during Induction in Newly Diagnosed Multiple Myeloma: Results of Two Prospective Studies by the German Myeloma Study Group…
2021
Background: Preservation of kidney function in newly diagnosed (ND) multiple myeloma (MM) helps to prevent excess toxicity. Patients (pts) from two prospective trials were analyzed, provided postinduction (PInd) restaging was performed. Pts received three cycles with bortezomib (btz), cyclophosphamide, and dexamethasone (dex
Chronic Background Radiation Correlates With Sperm Swimming Endurance in Bank Voles From Chernobyl
2022
Sperm quantity and quality are key features explaining intra- and interspecific variation in male reproductive success. Spermatogenesis is sensitive to ionizing radiation and laboratory studies investigating acute effects of ionizing radiation have indeed found negative effects of radiation on sperm quantity and quality. In nature, levels of natural background radiation vary dramatically, and chronic effects of low-level background radiation exposure on spermatogenesis are poorly understood. The Chernobyl region offers a unique research opportunity for investigating effects of chronic low-level ionizing radiation on reproductive properties of wild organisms. We captured male bank voles (Myo…
Next-Generation Sequencing (NGS) application to the detection of mutations endowing herbicide resistance
2014
The Next Generation Sequencing (NGS) technologies offer tremendous possibilities for accurate detection of mutations endowing resistance. Yet, their use for this purpose has not emerged in crop protection. We aim at promoting NGS use for herbicide resistance diagnosis. In an exemplary study, we describe a simple procedure for this purpose, useable by virtually any scientist and implementing freely accessible programs for the analysis of NGS data. Three PCR amplicons encompassing seven codons of the ALS gene that are crucial for herbicide resistance were sequenced using non-quantified pools of crude DNA extracts from 40 plants in each of 28 field populations of two species of barnyard-grass:…