Search results for "56"
showing 10 items of 1818 documents
Complete karyotype characterization of the K562 cell line by combined application of G-banding, multiplex-fluorescence in situ hybridization, fluores…
2001
This study combines conventional cytogenetics, fluorescence in situ hybridization (FISH), multiplex-FISH and comparative genomic hybridization (CGH). In applying this multimodal approach on the human leukemia cell line K562, the chromosome composition was refined in detail and compared with data from the literature. A hypotriploid karyotype with a modal chromosome number of 67, and 21 unique marker chromosomes were identified. The classification of six markers was identical to published data and the composition of five further markers from the literature could be fully clarified for the first time. The composition of another five markers, which have been interpreted in divergent ways in dif…
Exhumation of the High‐Pressure Tsäkkok Lens, Swedish Caledonides: Insights From the Structural and White Mica 40Ar/39Ar Geochronological Record
2020
Integrated structural, geochemical, and geochronological investigations were conducted on metasedimentary rocks in the eclogite-bearing Tsäkkok Lens of the Seve Nappe Complex (Scandinavian Caledonides) to resolve its exhumation history. Three deformation events are defined. D1 is likely related to the prograde to peak-metamorphic stages, represented by a locally preserved S1. D2 resulted in vertical shortening and is defined by a pervasive S2 and cm-/m-scale F2 closed folds. D2 terminated with Scandian thrusting, which emplaced the overlying Köli Nappe Complex. D3 records NE-SW shortening and constitutes m-/km-scale F3 open folds that deformed the Tsäkkok Lens and Köli Nappe Complex togethe…
Ploidy manipulation and citrus breeding, genetics and genomics
2020
Polyploidy appears to have played a limited role in citrus germplasm evolution. However, today, ploidy manipulation is an important component of citrus breeding strategies. For varieties, the main objective is to develop triploid seedless cultivars. For rootstock, the aim is to cumulate interesting traits in tetraploid hybrids and to improve adaptation to biotic and abiotic stresses. This chapter starts with a review of the recent knowledge acquired on the natural mechanisms of citrus polyploidization and tetraploid meiosis. Chromosome doubling of nucellar cells is frequent in apomictic citrus and results in tetraploid seedling production. Unreduced gametes are also frequently produced, mai…
Cytotoxicity and chemosensitizing activity of amphiphilic poly(glycerol)-poly(alkylene oxide) block copolymers.
2014
All polymeric chemosensitizers proposed thus far have a linear poly(ethylene glycol) (PEG) hydrophilic block. To testify whether precisely this chemical structure and architecture of the hydrophilic block is a prerequisite for chemosensitization, we tested a series of novel block copolymers containing a hyperbranched polyglycerol segment as a hydrophilic block (PPO-NG copolymers) on multi-drug-resistant (MDR) tumor cells in culture. PPO-NG copolymers inhibited MDR of three cell lines, indicating that the linear PEG can be substituted for a hyperbranched polyglycerol block without loss of the polymers' chemosensitizing activity. The extent of MDR reversal increased with the polymers affinity…
Oratio ad Sacrosanctum Oecumenicum Concilium Tridentinum, qua de ecclesiae auctoritate, et imitandis apostolis disseritur habita per... Gasparem A' F…
1563
Sign.: A4, B2
El Gran rescate de la prensa española: los anticipos reintegrables durante la Primera Guerra Mundial
2021
Resumen La crisis económica que se derivó de la Primera Guerra Mundial provocó, entre otros efectos, la caída aguda de los resultados económicos de la prensa española y una amenaza real de colapso generalizado. Reconvertida a grandes empresas, con exponentes como el primer trust periodístico español, creado en 1906, los editores de periódicos plantearon por primera vez un dilema clave para el sistema representativo: si se quería que existiese prensa, el tesoro público debía colaborar mediante subvenciones a la compra de papel. Se puso en marcha, de esta forma, el primer gran rescate de la prensa española, con una aportación millonaria de dinero público a empresas privadas que, en teoría, te…
Comment on "Lethally hot temperatures during the Early Triassic greenhouse".
2013
Sun et al . (Reports, 19 October 2012, p. 366) reconstructed Permian to Middle Triassic equatorial seawater temperatures. After correct temporal positioning of their data points, their presumed trends of temperature changes, and hence their assumption of a one-to-one relationship between putative "lethally hot" seawater temperatures and a disputable equatorial "eclipse" of some organisms, are no longer supported by their data.
Brief an Garlieb H. Merkel
1798
Ms. 930a, Nr. 10, Bl. 26r-28v Schmidt-Phiseldeck, Konrad von. Brief an Garlieb H. Merkel, Kopenhagen, am 6. März 1798 Autora rokraksts / Autograph, vācu un latīņu val. / Deutsch und Latein [6] lpp. / S. Attēlu numuri / Bildnummern: 930a-010-1 – 930a-010-6 Der Verfasser äußert zum Beginn seines Briefes erneut sein Bedauern über die räumliche Trennung und wünscht sich, nach Italien zu reisen. Weimar, wo Merkel zum gegebenen Zeitpunkt wahrscheinlich weilte, glorifiziert Schmidt-Phiseldeck mit der Bezeichnung als „Weimar-Athen“. Gleichzeitig drückt der Verfasser seine Enttäuschung über die Politik Frankreichs bezüglich der Schweiz aus, erkennt aber in der Neutralität seiner neuen Heimat Dänemar…
Agroecological engineering
2015
Earth has recently entered the new era of the Anthropocene, during which the rise of human activities are impacting for the first time ecosystems and climate on the global scale. Since the 1960s the green revolution has improved food production in quantity using industrially-designed agriculture, which has led to global pollution by pesticides and losses of food quality, biodiversity and soil carbon. As a consequence there is a need to implement agroecological practices in order to produce food safely and in a sustainable way. This virtual issue presents principles and applications of agroecological engineering, exemplified in 19 selected review articles from the journal Agronomy for Sustai…
Vaakakupissa vaarat ja vastuu: Julkisen palvelun median arvot sosiaalisen median alustojen paineessa
2021
Sosiaalisen median alustat ovat muovanneet media-alan prosesseja ja käytäntöjä merkittävästi. Alustayritysten toimintaa ohjaavat erilaiset arvot ja tavoitteet kuin mediaorganisaatioita, mikä aiheuttaa toimijoiden välille ristiriitaa. Toimintatavoistaan ja arvoistaan sosiaalisessa mediassa joutuvat neuvottelemaan erityisesti julkisen palvelun mediayhtiöt, joiden peruskivenä ovat julkisen palvelun arvot. Tarkastelemme tässä artikkelissa suomalaisen julkisen palvelun mediayhtiön Yleisradion alustasuhdetta laadullisen haastatteluaineiston avulla. Kysymme, miten Yleisradiossa kuvataan ja perustellaan suhdetta sosiaalisen median alustoihin ja minkälaiseen arvopuheeseen suhteen kuvaaminen kytkeyty…