Search results for "570"
showing 10 items of 1074 documents
Impacto científico y contextualización bibliométrica de la Pediatría respecto a otras áreas temáticas
2020
[ES] Introducción El objetivo de este trabajo es doble. Por una parte, identificar y caracterizar los indicadores de producción, citación, impacto y colaboración del área Pediatrics del Journal Citation Reports, y por otra, estudiar a la revista Anales de Pediatría en el contexto de las revistas españolas de otras 20 áreas y especialidades médicas. Material y método Las fuentes de información utilizadas para la obtención de los indicadores fueron Science Citation Index-Expanded, Journal Citation Reports y Scimago Journal & Country Rank. Se realizó un análisis de regresión para comprobar la correlación entre la citación y otras variables. Resultados Pediatrics ocupó el 8.o lugar en producció…
El plagio y las revistas depredadoras como amenaza a la integridad cientifica
2019
Resumen: Este artículo propone un análisis del concepto del plagio con la finalidad de mostrar el amplio espectro de manifestaciones que pueden ser consideradas como tal al incurrir en una transgresión de la propiedad intelectual, realizada con el ánimo de engañar sobre la verdadera contribución de los autores y sobre la originalidad y novedad de la información.Describe las distintas circunstancias en las que se incurre en un plagio intencional y el daño que esta mala conducta ocasiona en la credibilidad de un sistema científico, en el que el crédito de autoría es el fundamento de la carrera académica, del prestigio del autor en la comunidad científica y la base para la financiación de la i…
NECAB2 participates in an endosomal pathway of mitochondrial stress response at striatal synapses
2021
Synaptic signaling depends on ATP generated by mitochondria. Due to extensive connectivity, the striatum is especially vulnerable to mitochondrial dysfunction and thus requires efficient mitochondrial quality control. We found that the neuronal calcium-binding protein NECAB2 ensures synaptic function in the striatum by increasing mitochondrial efficiency. NECAB2 associates with early endosomes and mitochondria at striatal synapses. Loss of NECAB2 dysregulates proteins of the endosomal ESCRT machinery and oxidative phosphorylation. Mitochondria from NECAB2-deficient mice are more abundant but less efficient. These mitochondria exhibit increased respiration and superoxide production but produ…
Differential Effects of Fluvoxamine and Other Antidepressants on the Biotransformation of Melatonin
2001
Melatonin, the predominant product of the pineal gland, is involved in the maintenance of diurnal rhythms. Nocturnal blood concentrations of melatonin have been shown to be enhanced by fluvoxamine, but not by other serotonin reuptake inhibitors. Because fluvoxamine is an inhibitor of several cytochrome P450 (CYP) enzymes, the authors studied the biotransformation of melatonin and the effects of fluvoxamine on the metabolism of melatonin in vitro using human liver microsomes and recombinant human CYP isoenzymes. Melatonin was found to be almost exclusively metabolized by CYP1A2 to 6-hydroxymelatonin and N-acetylserotonin with a minimal contribution of CYP2C19. Both reactions were potently in…
Host glycoprotein Gp96 and scavenger receptor SREC interact with PorB of disseminating Neisseria gonorrhoeae in an epithelial invasion pathway.
2007
Neisseria gonorrhoeae expresses numerous surface proteins that mediate bacterial adherence and invasion during infection. Gonococci expressing serotype A of the major outer membrane porin PorB (PorB(IA)) are frequently isolated from patients with severe disseminating infections. PorB(IA) triggers efficient adherence and invasion under low phosphate conditions mimicking systemic bloodstream infections. Here, we identify the human heat shock glycoprotein Gp96 and the scavenger receptor SREC as PorB(IA)-specific receptors. Gonococci expressing PorB(IA), but not those expressing PorB serotype B instead, bind to purified native or recombinant Gp96. Depletion of Gp96 from host cells prevented adh…
Modello numerico per la simulazione e l’ottimizzazione di controlli non distruttivi con ultrasuoni
2013
I controlli non distruttivi basati sull’impiego di ultrasuoni sono ampiamente usati per la loro efficacia e affidabilità nel rilevamento di difetti. La generazione di onde ultrasonore e la propagazione in strutture di forma non regolare sono difficili da analizzare, soprattutto se la sorgente impiegata è un laser. Le tecniche numeriche per la simulazione del fenomeno reperibili in letteratura mostrano limiti di applicabilità per frequenze nel campo dei MHz e lunghezze d’onda molto corte. In questo lavoro presentiamo un metodo numerico in grado di risolvere accuratamente ed efficientemente problemi di generazione di onde ultrasonore tramite laser, con frequenze nel range dei MHz, e di propag…
Gross motor coordination: We have a problem! A study with the Körperkoordinations Test für Kinder in youth (6-13 Years)
2021
The main goal of our cross-sectional research was to determine the current values of gross motor coordination (GMC) of Italian boys and girls between 6 and 13 years of age. Secondary goals were to study gender differences, and the four subtests trend with ages. Results were compared with the references proposed by KTK authors and with similar searches. Anthropometric measurements and KTK data from 2,206 schoolchildren (girls: n = 1,050; boys: n = 1,156) were collected. The KTK raw score (RS) increased with the age of the subjects (r = 0.678; p < 0.001). In 11–13-year-old subjects, the increase in results is less than in younger subjects. RS showed differences by gender (F = 5.899; p …
The Robotic Construction Kit as a Tool for Cognitive Stimulation in Children and Adolescents: The RE4BES Protocol
2019
Through numerous experiences, the robotics has been demonstrated to have good potential in the field of strengthening social skills in children with Special Educational Needs and in particular with autism spectrum disorder. There are still not many experimental studies on the cognitive enhancement and social skills of children with special needs conducted with robotics construction kits that, requiring both the construction of the robot body and the programming of its “mind“, bring into play a multiplicity of cognitive and social skills. For the aforementioned reasons our team from the University of Palermo and from the Center MetaIntelligenze ONLUS developed the treatment protocol RE4BES, …
A study on maternal-fetal attachment in pregnant women undergoing fetal echocardiography
2017
Purpose: To investigate the possible effects of the fetal echocardiography experience on the prenatal attachment process. The predictive effect of specific women’s psychological variables will be explored as well. Design and methods: This between groups study involved 85 women with pregnancy at risk who underwent the fetal echocardiography, and 83 women who were about to undergo the morphological scan. The tools employed were: the Prenatal Attachment Inventory (P.A.I.) to explore the maternal-fetal attachment; the Maternity Social Support Scale to investigate the woman perception of being socially supported during pregnancy; both the Big Five Questionnaire and the FACES III to explore the p…
Sibship and Self-Esteem in Children With Asthma
2016
This study has explored the valence of sibship that may empower the self-esteem of children with asthma at the interpersonal, environmental control competence, emotionality management, and body-image levels. It has been assumed that the relationship between siblings may have a moderating effect on the negative impact that asthma has on child’s development. Seventy children suffering from chronic asthma have been involved: 40 children with siblings (experimental group) and 30 sibling-free children (control group). The children with asthma have exhibited higher levels of self-esteem in comparison with the sibling-free children. The results of the study, at the clinical significance level, hig…