Search results for "570"
showing 10 items of 1074 documents
Autophagy
2012
Klionsky, Daniel J. et al.
Editorial: Highlights of ENPER 2019—European Network for Plant Endomembrane Research Meeting
2021
published
Promoter Activation in Dhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing
2019
Abstract Natural products (NPs) from microorganisms have been important sources for discovering new therapeutic and chemical entities. While their corresponding biosynthetic gene clusters (BGCs) can be easily identified by gene‐sequence‐similarity‐based bioinformatics strategies, the actual access to these NPs for structure elucidation and bioactivity testing remains difficult. Deletion of the gene encoding the RNA chaperone, Hfq, results in strains losing the production of most NPs. By exchanging the native promoter of a desired BGC against an inducible promoter in Δhfq mutants, almost exclusive production of the corresponding NP from the targeted BGC in Photorhabdus, Xenorhabdus and Pseud…
Pole-to-Pole Connections : Similarities between Arctic and Antarctic Microbiomes and Their Vulnerability to Environmental Change
2017
The global biogeography of microorganisms remains poorly resolved, which limits the current understanding of microbial resilience toward environmental changes. Using high-throughput 16S rRNA gene amplicon sequencing, we characterized the microbial diversity of terrestrial and lacustrine biofilms from the Arctic, Antarctic and temperate regions. Our analyses suggest that bacterial community compositions at the poles are more similar to each other than they are to geographically closer temperate habitats, with 32% of all operational taxonomic units (OTUs) co-occurring in both polar regions. While specific microbial taxa were confined to distinct regions, representing potentially endemic popul…
Field-Based Health-Related Physical Fitness Tests in Children and Adolescents: A Systematic Review
2021
Physical fitness (PF) is a multi-component construct and a biomarker of health. Worse PF is related to vulnerability and predicts worse academic achievements. Thus, assessing PF is important to monitor health in youth. This systematic review aimed to identify and inform physical education, health professionals and entities about existing PF batteries and field-tests that can be used in school settings. A comprehensive literature search was carried out in five electronic databases (Academic Search Complete, Education Resources Information Center, PubMed, Scopus, and Web of Science) to identify PF battery protocols that can be carried out in the school setting. Overall, 24 PF batteries were i…
Sexually selected traits evolve positive allometry when some matings occur irrespective of the trait
2014
Positive allometry of secondary sexual traits (whereby larger individuals have disproportionally larger traits than smaller individuals) has been called one of the most pervasive and poorly understood regularities in the study of animal form and function. Its widespread occurrence is in contrast with theoretical predictions that it should evolve only under rather special circumstances. Using a combination of mathematical modeling and simulations, here we show that positive allometry is predicted to evolve under much broader conditions than previously recognized. This result hinges on the assumption that mating success is not necessarily zero for males with the lowest trait values: for examp…
Oral-Health-Related Quality of Life and Cosleeping: The Role of Nocturnal Breastfeeding
2021
The purpose of this paper is to analyse the association between cosleeping and the number of breastfeeding sessions in infants, OHRQoL of the child and the family, and the DMFT Child’s index. The sample comprised 273 children (2–4 years old). In addition to the clinical examination of the child to assess the DMFT Index, the mother was requested to complete a questionnaire to collect data about the breastfeeding practice, diet, dental hygiene, dental check-ups, quality of the child’s oral life, and family impact (ECOHIS Scale). The children’s OHRQoL is positively correlated with number of night-time breastfeeding sessions at 12 months (r2 = 0.40 **), DMFT index (r2 = 0.60 **), impact family …
Camera-LiDAR Data Fusion for Autonomous Mooring Operation
2020
Author's accepted manuscript. © 2020 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. The use of camera and LiDAR sensors to sense the environment has gained increasing popularity in robotics. Individual sensors, such as cameras and LiDARs, fail to meet the growing challenges in complex autonomous systems. One such scenario is autonomous mooring, where the ship has to …
Probabilistic models for the fatigue resistance of welded steel joints subjected to constant amplitude loading
2022
Abstract S-N curves found in various rules and regulations are the basic tool for the practicing engineer when carrying out life predictions for welded details in dynamically loaded structures. The present work is investigating the expected fatigue life and associated scatter for welded steel joints subjected to Constant Amplitude (CA) loading. The objective is to obtain more reliable life predictions based on advancements in the probabilistic model fitted to collected life data. A Random Fatigue Limit Model (RFLM) is proposed to obtain fatigue resistance curves at given probability levels of survival. As a distinction to more conventional statistical methods, the model is treating both the…
Medicamentos utilizados en pediatría extrahospitalaria: ¿disponemos de información suficiente?
2008
Objetivo: Analizar los medicamentos que reciben los pacientes pediátricos en el ámbito extrahospitalario y la información disponible sobre los mismos. Pacientes y métodos: Estudio transversal, observacional y descriptivo realizado en una muestra de pacientes menores de 14 años atendidos en urgencias del Servicio de Pediatría del Consorcio Hospital General Universitario de Valencia entre junio 2005 y agosto 2006. Se cuantifican y clasifican los medicamentos utilizados antes de acudir a urgencias y se analiza la información sobre su uso que contiene el Vademécum Internacional Medicom y la ficha técnica. Resultados: Se recogió información sobre 462 niños con media de edad de 5,2 años (interval…