Search results for "570"
showing 10 items of 1074 documents
Reductive modification of genetically encoded 3-nitrotyrosine sites in alpha synuclein expressed in E.coli
2019
Tyrosine nitration is a post-translational protein modification relevant to various pathophysiological processes. Chemical nitration procedures have been used to generate and study nitrated proteins, but these methods regularly lead to modifications at other amino acid residues. A novel strategy employs a genetic code modification that allows incorporation of 3-nitrotyrosine (3-NT) during ribosomal protein synthesis to generate a recombinant protein with defined 3-NT-sites, in the absence of other post-translational modifications. This approach was applied to study the generation and stability of the 3-NT moiety in recombinant proteins produced in E.coli. Nitrated alpha-synuclein (ASYN) was…
FMEA - BASIC CONCEPT IN PRODUCT QUALITY
2018
Failure modes and effects analysis (FMEA) is a systematic procedure for analyzing a system (the entire system or just an assembly, subassembly or component) to identify potential failure modes, causes and effects of each failure on system operation. A somewhat different definition was formulated by Goddard Space Flight Center (USA) : FMEA is a procedure whereby every credible way of defeating each item from the lower decomposition level to the highest level is analyzed to determine effects on the system and classify each potential way of failure according to the severity of its effect.
RISK ANALISYS REGARDING HEALTH AND SAFETY AT WORK
2018
The work was created according to the provisions of the work safety legislation in force, regarding the obligation of the management of the economic agents to correctly determine the risk factors in order to ensure the measures for prevention of accidents and professional illnesses. The analysis presents the main aspects of the frequent mistakes that may arise in the risk assessment. So, it has been concluded that risks are inevitable in business, and that each activity is unique, as well as the risks from one activity to another or from one group of activities to another. Under these circumstances, it has been established that the success of an enterprise depends on how the risks were mana…
Temperature effects explain continental scale distribution of cyanobacterial toxins
2018
Insight into how environmental change determines the production and distribution of cyanobacterial toxins is necessary for risk assessment. Management guidelines currently focus on hepatotoxins (microcystins). Increasing attention is given to other classes, such as neurotoxins (e.g., anatoxin-a) and cytotoxins (e.g., cylindrospermopsin) due to their potency. Most studies examine the relationship between individual toxin variants and environmental factors, such as nutrients, temperature and light. In summer 2015, we collected samples across Europe to investigate the effect of nutrient and temperature gradients on the variability of toxin production at a continental scale. Direct and indirect…
Biology of the sauropod dinosaurs: the evolution of gigantism
2010
The herbivorous sauropod dinosaurs of the Jurassic and Cretaceous periods were the largest terrestrial animals ever, surpassing the largest herbivorous mammals by an order of magnitude in body mass. Several evolutionary lineages among Sauropoda produced giants with body masses in excess of 50 metric tonnes by conservative estimates. With body mass increase driven by the selective advantages of large body size, animal lineages will increase in body size until they reach the limit determined by the interplay of bauplan, biology, and resource availability. There is no evidence, however, that resource availability and global physicochemical parameters were different enough in the Mesozoic to ha…
SETAC GLB and SETAC Europe SAC: a liaison promoting the next generation of ecotoxicologists and environmental chemists
2018
Environmental sciences Europe 30(1), 41s12302-018-0171-z (2018). doi:10.1186/s12302-018-0171-z
Personality predicts social dominance in female zebra finches, Taeniopygia guttata, in a feeding context.
2011
6 pages; International audience; Although personality has been defined as a suite of correlated behaviours, most studies of animal personality actually consider correlations between a few traits. We examined the repeatability and correlational structure of five potential personality traits (activity, neophobia, exploratory tendencies, risk-taking behaviour and obstinacy), in female zebra finches. In addition, we assessed to what extent personality influenced social dominance in a feeding context in this gregarious species. All personality traits were found to be highly repeatable within individuals. In addition, except for obstinacy, all of them were related to each other, thus defining a b…
Plagiarism and predatory journals: A threat to scientific integrity
2018
This article presents an analysis of the concept of plagiarism in order to show the wide spectrum of manifestations that can be considered as such when committing a transgression of intellectual property, carried out with the intention of deceiving the authors’ true contribution and the originality and novelty of the information. It describes the different circumstances in which intentional plagiarism has occurred, and the damage that this misconduct causes in the credibility of the scientific system, in which authorship credit is the foundation of the academic career, of the prestige of the author in the scientific community, and the basis for financing research. Some circumstances are fav…
Childhood Obesity and Maternal Personality Traits: A New Point of View on Obesity Behavioural Aspects.
2021
The epidemic spread of childhood obesity in Western society has interested many researchers, who agree in defining it as a multifactorial disease in which not only eating habits and sedentary lifestyle play a role, but also genetic predisposition. The aim of this study was to analyze the personality profile of a group of mothers of children with obesity and to compare this profile to that of a group of mothers of children without obesity. A total of 258 mothers participated in the study (126 mothers of children with obesity and 132 mothers of children without obesity). Weight and height were measured and the body mass index was calculated. The Minnesota Multiphasic Personality Inventory sec…
Providing pediatric well-care and sick visits in the COVID-19 pandemic era: the recommendations of the Italian pediatric society.
2020
AbstractPediatricians have observed a significant decrease in in-person child health visits during the COVID-19 pandemic. In the post lockdown period, the coronavirus trend remains positive in Italy but fears of a second wave have recently grown in Italy due to active hotbeds of contagion. The pandemic may negatively affect the care of pediatric patients and overall children welfare as it may present with severe signs and symptoms or it may complicate. The Italian Pediatric Society recommend to separate well visits from sick ones, to educate families and to promote hygienic strategies to provide an adequate pediatric assistance in case of a second pandemic wave.