Search results for "594"
showing 9 items of 9 documents
Oncolytic Virotherapy as Emerging Immunotherapeutic Modality: Potential of Parvovirus H-1
2014
Human tumors develop multiple strategies to evade recognition and efficient suppression by the immune system. Therefore, a variety of immunotherapeutic strategies have been developed to reactivate and reorganize the human immune system. The recent development of new antibodies against immune check points may help to overcome the immune silencing induced by human tumors. Some of these antibodies have already been approved for treatment of various solid tumor entities. Interestingly, targeting antibodies may be combined with standard chemotherapy or radiation protocols. Furthermore, recent evidence indicates that intratumoral (it) or intravenous (iv) injections of replicative oncolytic viruse…
Two Remarkably Luminous Galaxy Candidates at z ≈ 10-12 Revealed by JWST
2022
The first few 100 Myr at z > 10 mark the last major uncharted epoch in the history of the universe, where only a single galaxy (GN-z11 at z ≈ 11) is currently spectroscopically confirmed. Here we present a search for luminous z > 10 galaxies with JWST/NIRCam photometry spanning ≈1–5 μm and covering 49 arcmin2 from the public JWST Early Release Science programs (CEERS and GLASS). Our most secure candidates are two MUV ≈ −21 systems: GLASS-z12 and GLASS-z10. These galaxies display abrupt ≳1.8 mag breaks in their spectral energy distributions (SEDs), consistent with complete absorption of flux bluewards of Lyα that is redshifted to =+z12.40.3 0.1and=+z10.40.5 0.4. Lower redshift interlopers su…
Dzieje ludności żydowskiej na terenach latyfundium Zamoyskich za czasów linii kanclerskiej (Jan „Sariusz”, Tomasz, Jan „Sobiepan” Zamoyscy). Przyczyn…
2014
Celem artykułu jest omówienie dziejów ludności żydowskiej na terenach należących do rodziny Zamoyskich w okresie od drugiej połowy XVI do drugiej połowy XVII wieku, w kresie rządów założyciela ordynacji Jana „Sariusza” Zamoyskiego (1542 – 1605), jego syna Tomasza Zamoyskiego (1594 – 1638) oraz wnuka Jana „Sobiepana” Zamoyskiego (1627 – 1665), ostatniego ordynata z tzw. linii starszej, zwanej też „kanclerską”. Zostały w nim omówione warunki polityczne, jakie towarzyszyły osiedlaniu się Żydów w latyfundium Zamoyskich (w szczególności w większych ośrodkach miejskich: Zamościu, Szczebrzeszynie, Tomaszowie, Kraśniku oraz Tarnogrodzie) oraz aspekty społeczne, kulturowe i gospodarcze ich funkcjono…
Riga devicta ab augustissimo principe Gvstavo Adolpho Svecorvm, Gothorvm, Vandalorvmqve rege, magno principe Finlandiae, duce Esthoniae, Careliaque, …
1625
Saturs:Apsveikuma dzejolis: Illustri ac generoso Domino Iacobo de la Gardie [..] Rigensis Gubernatori &c. post devictam Derpatum, plurimasque arces Livoniae, filiola divinitus orbato [39.-40.] lpp. (Grāfam Jakobam Delagardijam Zviedrijas militārajam un valsts darbiniekam, feldmaršalam (1620), Zviedru Vidzemes ģenerālgubernatoram (1621–1628)). Izdevums pieejams arī: https://digital.slub-dresden.de/werkansicht/dlf/20246/
Le Dieu masque
2015
International audience; ...
Poussin et Louis XIV : peinture et monarchie dans la France du Grand siècle
2015
International audience; Dans cet essai, l'auteur, Olivier Bonfait s'emploie à résoudre le paradoxe suivant : comment Nicolas Poussin, dont la carrière s'est déroulée à un ou deux ans près hors de France, a fini par incarner pour les théoriciens et les amateurs du XVIIe siècle puis les manuels d'histoire le peintre par excellence du "siècle de Louis XIV" au sens esthétique du terme.Comment Poussin, qui a peint presque tous ses tableaux à Rome, est-il devenu un artiste français ? Pourquoi un peintre dont le séjour à Paris fut un échec est-il un héros national ? Dans les histoires qui relient Poussin à la France au XVIIe siècle, de Richelieu à Fénélon, une suite de méprises furent à l’origine …
Striking a Balance among Security, Privacy and Competition. The Data Retention and Investigatory Powers Act 2014 (DRIP)
2015
Following the ECJ decision that declared the Data Retention Directive invalid, the Data Retention and Investigatory Powers Act 2014 (DRIP) has been enacted. It is not indisputable whether the DRIP gives more powers to the intelligence services at the detriment of both citizens’ privacy and freedom of enterprise or whether it simply clarifies the nature and extent of obligations that can be imposed on telecommunications service providers based outside the UK under Part 1 of the Regulation of Investigatory Powers Act 2000 (RIPA). The article provides news also on Data Retention Regulations 2014, R (David Davis MP and Tom Watson MP) v Secretary of State for the Home Department and the proposed…
The NUPR1/p73 axis contributes to sorafenib resistance in hepatocellular carcinoma
2021
The multikinase inhibitor sorafenib was the first drug approved by the FDA for treating patients with advanced hepatocellular carcinoma (HCC). However, sorafenib resistance remains a major challenge for improving the effectiveness of HCC treatment. Previously, we identified several genes modulated after sorafenib treatment of human HCC cells, including the stress-inducible nuclear protein 1 (NUPR1) gene. Multiple studies have shown that NUPR1 regulates autophagy, apoptosis, and chemoresistance. Here, we demonstrate that treatment of HCC cells with sorafenib resulted in the activation of autophagic flux. NUPR1 knock-down (KD) in HCC cells was associated with increased p62 expression, suggest…
Peindre « La Jérusalem délivrée » au XVIIe siècle : poésie épique et représentation tragique
1994
International audience