Search results for "59"

showing 10 items of 1607 documents

The NUPR1/p73 axis contributes to sorafenib resistance in hepatocellular carcinoma

2021

The multikinase inhibitor sorafenib was the first drug approved by the FDA for treating patients with advanced hepatocellular carcinoma (HCC). However, sorafenib resistance remains a major challenge for improving the effectiveness of HCC treatment. Previously, we identified several genes modulated after sorafenib treatment of human HCC cells, including the stress-inducible nuclear protein 1 (NUPR1) gene. Multiple studies have shown that NUPR1 regulates autophagy, apoptosis, and chemoresistance. Here, we demonstrate that treatment of HCC cells with sorafenib resulted in the activation of autophagic flux. NUPR1 knock-down (KD) in HCC cells was associated with increased p62 expression, suggest…

SorafenibCancer ResearchCarcinoma HepatocellularSettore MED/09 - Medicina InternaHepatocellular carcinomap73Mice NudeApoptosisSettore BIO/11 - Biologia MolecolareMiceNSC5594In vivoPumaBasic Helix-Loop-Helix Transcription FactorsmedicineAutophagyNSC5994AnimalsHumansGene silencingneoplasmsbiologyActivator (genetics)business.industryLiver NeoplasmsAutophagyApoptosiTumor Protein p73Hep G2 CellsSorafenibbiology.organism_classificationmedicine.diseasedigestive system diseasesNeoplasm ProteinsOncologyDrug Resistance NeoplasmApoptosisHepatocellular carcinomaCancer researchFemalebusinessNUPR1medicine.drug
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Individuazione dei carichi disturbanti nei sistemi di potenza. Una strategia basata su misure di potenze non attive

2010

Sorgenti armoniche potenze non attive IEEE 1459Settore ING-INF/07 - Misure Elettriche E Elettroniche
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Desde el hueco, la posmemoria

2019

Soriano MuñozUNESCO::CIENCIAS DE LAS ARTES Y LAS LETRASla posmemoria Celestina SoutoNuria 2 7:CIENCIAS DE LAS ARTES Y LAS LETRAS [UNESCO]1575-2259 2322 Pasajes: Revista de pensamiento contemporáneo 517256 2019-2019 56 6921516 Desde el huecoRevista de pensamiento contemporáneo 517256 2019-2019 56 6921516 Desde el hueco [1575-2259 2322 Pasajes]Luz
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Materialitäten der Kindheit

2020

Der Band fasst aktuelle Theorieperspektiven und Forschungsbefunde zur Bedeutung von Körpern, Objekten und Räumen in der interdisziplinären Kindheitsforschung zusammen. Es wird gezeigt, in welchem Maße diese Materialitäten daran mitwirken, dass sich bestimmte gesellschaftliche Kindheitsmuster und -erfahrungen ausbilden und wie material die Positionierungs- und Subjektivierungsprozesse von Kindern als Kinder gedacht werden müssen.

Soziologie/dk/atira/pure/core/keywords/559095953ErziehungswissenschaftenSchüler und SchülerinnenSpielräumeKinderChildhood ResearchKinderkörper/dk/atira/pure/core/keywords/558306934BildungswirtschaftKinderzimmerKindheitKindheitsforschung
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CCDC 1569570: Experimental Crystal Structure Determination

2019

Related Article: Elena Prigorchenko, Sandra Kaabel, Triin Narva, Anastassia Baškir, Maria Fomitšenko, Jasper Adamson, Ivar Järving, Kari Rissanen, Toomas Tamm, Riina Aav|2019|Chem.Commun.|55|9307|doi:10.1039/C9CC04990H

Space GroupCrystallography1310121921283037394648-dodecaazatridecacyclo[46.6.1.1310.11219.12128.13037.13946.049.01318.02227.03136.04045.04954]hexacontane-555657585960-hexone deuterochloroform solvateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1816643: Experimental Crystal Structure Determination

2018

Related Article: Ben-Lin, Hu Ke Zhang, Cunbin An, Dieter Schollmeyer, Wojciech Pisula, Martin Baumgarten|2018|Angew.Chem.,Int.Ed.|57|12375|doi:10.1002/anie.201803230

Space GroupCrystallography1117232941475359-octakis((2-[triisopropylsilyl]ethynyl))-2050-dithia-3715192125333745495155-dodecaazaheptadecacyclo[37.21.2.2927.0238.0436.0634.0832.01426.01624.01822.04362.04456.04654.04852.05761.01364.03163]tetrahexaconta-1(61)246(34)79(64)1012141618212325272931(63)32353739(62)40424446485153555759-hentriacontaene tetrahydrofuran solvateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 705737: Experimental Crystal Structure Determination

2009

Related Article: D.Meshcheryakov, V.Bohmer, M.Bolte, V.Hubscher-Bruder, F.Arnaud-Neu|2009|Chem.-Eur.J.|15|4811|doi:10.1002/chem.200802573

Space GroupCrystallography97979898-Tetramethyl-3435191-tetra-t-butyl-153147637995-hexaoxa-6822243840545670728688-dodeca-azapentadecacyclo[91.3.1.1^4549^.0^596^.0^914^.0^1621^.0^2530^.0^3237^.0^4146^.0^4853^.0^5762^.0^6469^.0^7378^.0^8085^.0^8994^]octanonaconta-1(96)2491113161820252729323436414345485052575961646668737577808284899193-hexatriacontaene-72339557187-hexone ethanol ethyl acetate solvateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 687874: Experimental Crystal Structure Determination

2009

Related Article: D.Meshcheryakov, F.Arnaud-Neu, V.Boehmer, M.Bolte, J.Cavaleri, V.Hubscher-Bruder, I.Thondorf, S.Werner|2008|Org.Biomol.Chem.|6|3244|doi:10.1039/b808773c

Space GroupCrystallographyCrystal System31119273559-hexa-t-butyl-656566666767-hexamethyl-15314763-tetraoxa-68222438405456-octaazadodecacyclo[59.3.1.1^1317^.1^2933^.0^564^.0^914^.0^1621^.0^2530^.0^3237^.0^4146^.0^4853^.0^5762^]heptahexaconta-1(64)2491113161820252729323436414345485052575961-tetracosaene-7233955-tetrone acetonitrile solvateCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 265476: Experimental Crystal Structure Determination

2005

Related Article: Yudong Cao, Leyong Wang, M.Bolte, M.O.Vysotsky, V.Bohmer|2005|Chem.Commun.||3132|doi:10.1039/b505223h

Space GroupCrystallographyCrystal System6177101105-Tetramethoxy-415213238498697-octaoxa-55578183102104106108-octaazatridecacyclo(50.33.12.31872.33566.1384.11620.1333715054.15862.16078.16468.17074.17680) dodecahecta-13(98)16(112)171933(111)343650(110)515358(109)596164 (105)656770(101)717376(99)777984-tetracosaene-5682103107-tetraone methanol solvate sesquihydrateCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 687875: Experimental Crystal Structure Determination

2009

Related Article: D.Meshcheryakov, F.Arnaud-Neu, V.Boehmer, M.Bolte, J.Cavaleri, V.Hubscher-Bruder, I.Thondorf, S.Werner|2008|Org.Biomol.Chem.|6|3244|doi:10.1039/b808773c

Space GroupCrystallographyCrystal SystemCrystal Structure31119273559-hexa-t-butyl-656566666767-hexamethyl-15314763-tetraoxa-68222438405456-octaazadodecacyclo[59.3.1.1^1317^.1^2933^.0^564^.0^914^.0^1621^.0^2530^.0^3237^.0^4146^.0^4853^.0^5762^]heptahexaconta-1(64)2491113161820252729323436414345485052575961-tetracosaene-7233955-tetrone ethanol solvateCell ParametersExperimental 3D Coordinates
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