Search results for "5a"
showing 4 items of 204 documents
Resolvent estimates for elliptic quadratic differential operators
2011
Sharp resolvent bounds for non-selfadjoint semiclassical elliptic quadratic differential operators are established, in the interior of the range of the associated quadratic symbol.
Jeu de Taquin and Diamond Cone for so(2n+1, C)
2020
International audience; The diamond cone is a combinatorial description for a basis of a natural indecomposable n-module, where n is the nilpotent factor of a complex semisimple Lie algebra g. After N. J. Wildberger who introduced this notion, this description was achieved for g = sl(n) , the rank 2 semisimple Lie algebras and g = sp (2n).In this work, we generalize these constructions to the Lie algebra g = so(2n + 1). The orthogonal semistandard Young tableaux were defined by M. Kashiwara and T. Nakashima, they index a basis for the shape algebra of so(2n + 1). Defining the notion of orthogonal quasistandard Young tableaux, we prove that these tableaux describe a basis for a quotient of t…
Modulation of Hepatitis C Virus NS5A Hyperphosphorylation by Nonstructural Proteins NS3, NS4A, and NS4B
1999
NS5A of the hepatitis C virus (HCV) is a highly phosphorylated protein involved in resistance against interferon and required most likely for replication of the viral genome. Phosphorylation of this protein is mediated by a cellular kinase(s) generating multiple proteins with different electrophoretic mobilities. In the case of the genotype 1b isolate HCV-J, in addition to the basal phosphorylated NS5A (designated pp56), a hyperphosphorylated form (pp58) was found on coexpression of NS4A (T. Kaneko, Y. Tanji, S. Satoh, M. Hijikata, S. Asabe, K. Kimura, and K. Shimotohno, Biochem. Biophys. Res. Commun. 205:320‐326, 1994). Using a comparative analysis of two full-length genomes of genotype 1b…
In vitro studies on the activation of the hepatitis C virus NS3 proteinase by the NS4A cofactor.
1996
AbstractProteolytic processing of the nonstructural proteins of the hepatitis C virus (HCV) is mediated by two viral proteinases: the NS2-3 proteinase cleaving at the NS2/3 junction and the NS3 serine-type proteinase responsible for processing at the NS3/4A, NS4A/B, NS4B/5A, and NS5A/B sites. Activity of the NS3 proteinase is modulated by NS4A. In the absence of this cofactor processing at the NS3-dependent sites does not occur or, in the case of the NS5A/B junction, is poor but increased when NS4A is present. Although recent studies demonstrated that proteinase activation requires direct interaction between NS3 and NS4A, the mechanism by which NS4A exerts the activation function is not kno…