Search results for "5aR*"
showing 10 items of 204 documents
Identification and characterization of amphiphysin II as a novel cellular interaction partner of the hepatitis C virus NS5A protein.
2003
The hepatitis C virus (HCV) NS5A protein is highly phosphorylated by cellular protein kinases. To study how NS5A might be integrated in cellular kinase signalling, we isolated phosphoproteins from HuH-7 hepatoma cells that specifically interacted with recombinant NS5A protein. Subsequent mass spectrometry identified the adaptor protein amphiphysin II as a novel interaction partner of NS5A. Mutational analysis revealed that complex formation is primarily mediated by a proline-rich region in the C-terminal part of NS5A, which interacts with the amphiphysin II Src homology 3 domain. Importantly, we could further demonstrate specific co-precipitation and cellular co-localization of endogenous a…
Unitary Groups Acting on Grassmannians Associated with a Quadratic Extension of Fields
2006
Let (V, H) be an anisotropic Hermitian space of finite dimension over the algebraic closure of a real closed field K. We determine the orbits of the group of isometries of (V, H) in the set of K-subspaces of V . Throughout the paper K denotes a real closed field and K its algebraic closure. Then it is well known (see, for example, [4, Chapter 2], [23]; see also [8]) that K = K(i) with i = √−1. Also we let (V,H) be an anisotropic Hermitian space (with respect to the involution underlying the quadratic field extension K/K) of finite dimension n over K. In this context we consider the natural action of the unitary group U = U(V,H) of isometries of (V,H) on the set Xd of all ddimensional K-subs…
On the Russo-Dye Theorem for positive linear maps
2019
Abstract We revisit a classical result, the Russo-Dye Theorem, stating that every positive linear map attains its norm at the identity.
Weighted norm inequalities in a bounded domain by the sparse domination method
2019
AbstractWe prove a local two-weight Poincaré inequality for cubes using the sparse domination method that has been influential in harmonic analysis. The proof involves a localized version of the Fefferman–Stein inequality for the sharp maximal function. By establishing a local-to-global result in a bounded domain satisfying a Boman chain condition, we show a two-weight p-Poincaré inequality in such domains. As an application we show that certain nonnegative supersolutions of the p-Laplace equation and distance weights are p-admissible in a bounded domain, in the sense that they support versions of the p-Poincaré inequality.
Guava (Psidium guajava L.) Leaf Extract as Bioactive Substances for Anti-Androgen and Antioxidant Activities
2022
Leaves of guava (Psidium guajava L.) have been used in Thai folk medicine without any supporting evidence as a traditional herbal remedy for hair loss. Androgenetic alopecia (AGA) is chronic hair loss caused by effects of androgens in those with a genetic predisposition, resulting in hair follicle miniaturization. Our objectives were to provide the mechanistic assessment of guava leaf extract on gene expressions related to the androgen pathway in well-known in vitro models, hair follicle dermal papilla cells (HFDPC), and human prostate cancer cells (DU-145), and to determine its bioactive constituents and antioxidant activities. LC-MS analysis demonstrated that the main components of the et…
A RADIATION CONDITION FOR UNIQUENESS IN A WAVE PROPAGATION PROBLEM FOR 2-D OPEN WAVEGUIDES
2009
We study the uniqueness of solutions of Helmholtz equation for a problem that concerns wave propagation in waveguides. The classical radiation condition does not apply to our problem because the inhomogeneity of the index of refraction extends to infinity in one direction. Also, because of the presence of a waveguide, some waves propagate in one direction with different propagation constants and without decaying in amplitude. Our main result provides an explicit condition for uniqueness which takes into account the physically significant components, corresponding to guided and non-guided waves; this condition reduces to the classical Sommerfeld-Rellich condition in the relevant cases. Final…
Hypusinated eIF5A is required for the translation of collagen
2021
AbstractThe evolutionary conserved elongation factor eIF5A is required for the translation of mRNAs that encode protein sequences with consecutive prolines or combined with glycine and charged amino acids. Mammalian collagens are enriched in putative eIF5A-dependent Pro-Gly-containing tripeptides. Here, we show that eIF5A is needed for heterologous expression of collagen in yeast, and using a dual luciferase reporter system we confirmed that eIF5A depletion interrupts translation at Pro-Gly-collagenic motifs. Using mouse fibroblasts, we showed that depletion of active eIF5A reduced collagen 1α (Col1a1) content, which became concentrated around the nuclei, in contrast to a stronger and all o…
Mahonian STAT on rearrangement class of words
2017
In 2000, Babson and Steingr\'{i}msson generalized the notion of permutation patterns to the so-called vincular patterns, and they showed that many Mahonian statistics can be expressed as sums of vincular pattern occurrence statistics. STAT is one of such Mahonian statistics discoverd by them. In 2016, Kitaev and the third author introduced a words analogue of STAT and proved a joint equidistribution result involving two sextuple statistics on the whole set of words with fixed length and alphabet. Moreover, their computer experiments hinted at a finer involution on $R(w)$, the rearrangement class of a given word $w$. We construct such an involution in this paper, which yields a comparable jo…
Pattern statistics in faro words and permutations
2021
We study the distribution and the popularity of some patterns in $k$-ary faro words, i.e. words over the alphabet $\{1, 2, \ldots, k\}$ obtained by interlacing the letters of two nondecreasing words of lengths differing by at most one. We present a bijection between these words and dispersed Dyck paths (i.e. Motzkin paths with all level steps on the $x$-axis) with a given number of peaks. We show how the bijection maps statistics of consecutive patterns of faro words into linear combinations of other pattern statistics on paths. Then, we deduce enumerative results by providing multivariate generating functions for the distribution and the popularity of patterns of length at most three. Fina…
2′,5′-oligoadenylate synthetase from a lower invertebrate, the marine sponge Geodia cydonium, does not need dsRNA for its enzymatic activity
2002
AbstractRecently, the presence of 2′,5′-linked oligoadenylates and a high 2′,5′-oligoadenylate synthetase activity were discovered in a lower invertebrate, the marine sponge Geodia cydonium. It has been demonstrated that mammalian 2–5A synthetase isozymes require a dsRNA cofactor for their enzymatic activity. Our results show that, unlike mammalian 2–5A synthetases, the 2–5A synthetase from the sponge acts in a dsRNA-independent manner in vitro. A prolonged incubation of the G. cydonium extract with a high concentration of a micrococcal nuclease had no effect on the activity of the 2–5A synthetase. At the same time, the micrococcal nuclease was effective within 30 min in degrading dsRNA nee…