Search results for "5′-monophosphate"

showing 3 items of 3 documents

Nitric Oxide System and Bronchial Epithelium: More Than a Barrier

2021

Airway epithelium forms a physical barrier that protects the lung from the entrance of inhaled allergens, irritants, or microorganisms. This epithelial structure is maintained by tight junctions, adherens junctions and desmosomes that prevent the diffusion of soluble mediators or proteins between apical and basolateral cell surfaces. This apical junctional complex also participates in several signaling pathways involved in gene expression, cell proliferation and cell differentiation. In addition, the airway epithelium can produce chemokines and cytokines that trigger the activation of the immune response. Disruption of this complex by some inflammatory, profibrotic, and carcinogens agents c…

0301 basic medicinecyclic guanosine-3′PhysiologyInflammationReviewCell junctionNitric oxideAdherens junction03 medical and health scienceschemistry.chemical_compound0302 clinical medicinenitric oxidePhysiology (medical)medicineQP1-981bronchial epitheliumLungTight junctionnitric oxide synthasesoluble guanylyl cyclaserespiratory systemrespiratory tract diseases030104 developmental biologymedicine.anatomical_structure030228 respiratory systemchemistryExhaled nitric oxideCancer researchRespiratory epithelium5′-monophosphatemedicine.symptomFrontiers in Physiology
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Chemical speciation of nucleotide 5′-monophosphates in the presence of biogenic amines

2001

The interaction of adenosine-, uridine-, inosine- and guanosine-5’-monophosphates with protonated ethylenediamine, putrescine, cadaverine, spermidine and spermine, was studied potentiometrically, a...

CadaverineChemical Health and SafetyStereochemistryHealth Toxicology and MutagenesisSpermineEthylenediamineToxicologyMedicinal chemistryBiogenic PolyaminesUridineSpermidinechemistry.chemical_compoundchemistrynucleotide 5′-monophosphates; biogenic polyamines; nucleotide 5′-monophosphate-polyammonium cation complexes; speciationmedicinePutrescineInosinemedicine.drug
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Relationship between airway sensitivity to adenosine 5' monophosphate and the shape of the concentration-response curve to methacholine in subjects w…

2001

Abstract The objective of this study was to determine differences in airway sensitivity to adenosine 5′-monophosphate (AMP) between allergic rhinitis subjects with plateau and those without evidence of plateau on the concentration–response curves to methacholine. A total of 51 adults (38 subjects with allergic rhinitis and 13 healthy controls) were challenged with increasing concentrations of methacholine and AMP. The methacholine challenge was terminated when there was a 40% or more decrease in forced expiratory volume in 1 sec (FEV 1 ), whereas the AMP challenge was stopped when FEV 1 had fallen by more than 20%. A plateau for methacholine was detected in all 13 healthy controls and in 27…

Pulmonary and Respiratory MedicineAdenosine monophosphateSpirometryAdultMalemedicine.medical_specialtyAllergyRhinitis Allergic PerennialBronchoconstrictionVital CapacityBronchial Provocation TestsStatistics NonparametricBronchoconstrictor Agentschemistry.chemical_compoundmethacholine.adenosine 5′-monophosphateInternal medicineForced Expiratory VolumemedicineHumansMethacholine ChlorideAnalysis of Varianceallergic rhinitismedicine.diagnostic_testConcentration ResponseDose-Response Relationship Drugbusiness.industryRhinitis Allergic Seasonalmedicine.diseaseAdenosineAdenosine MonophosphateEndocrinologychemistryAnesthesiaCase-Control StudiesMethacholineBronchoconstrictionFemalemedicine.symptombusinessAirwaymedicine.drugRespiratory medicine
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