Search results for "6-OHDA"
showing 5 items of 5 documents
Effects of Substantia Nigra pars compacta lesion on the behavioral sequencing in the 6-OHDA model of Parkinson’s disease
2019
The basal ganglia circuitry plays a crucial role in the sequential organization of behavior. Here we studied the behavioral structure of the animals after 21 days of 6-OHDA-induced lesion of the dopaminergic nigrostriatal system. Frequencies and durations of individual components of the behavioral repertoire were calculated; moreover, whether a temporal organization of the activity was present, it was investigated by using T-pattern analysis, a multivariate approach able to detect the real-time sequential organization of behavior. Six sham-depleted and six rats with unilateral 6−OHDA-lesion of the Substantia Nigra pars compacta were used. As to quantitative evaluations, the comparison betwe…
Involvement of Nitric Oxide in Nigrostriatal Dopaminergic System Degeneration : A Neurochemical Study.
2009
The present study was undertaken to explore the involvement of nitric oxide (NO) in the 6-hydroxydopamine (6-OHDA) experimental model of Parkinson's disease (PD) in rats. The effect of pharmacological manipulation of the NO system was evaluated on striatal dopamine (DA) level decrease produced by the toxin. 7-nitroindazole (7-NI, 50 mg/kg i.p.; n= 5) pretreatment significantly restored the striatal DA contents. Conversely, 40 mg/kg i.p. of molsidomine (MOL, n= 5), an NO donor, significantly worsened the neurodegeneration (n= 5) and completely counteracted the neuroprotective effect of 7-NI (n= 5). Thus, a crucial role for NO in 6-OHDA induced neurodegeneration is suggested together with a p…
No zoba pulpas cilmes šūnām izolētu eksosomu ietekme uz dzīvnieku gaitu 6-hidroksidopamīna inducētā Pārkinsona slimības modelī žurkās
2019
Pārkinsona slimība ir otra visbiežāk sastopamā neirodeģeneratīvā saslimšana pasaulē, kuras incidence turpina pieaugt. Slimības pacientiem raksturīgi gaitas traucējumi, kas ļoti ierobežo dzīves kvalitāti. Diemžēl joprojām nav atrasta efektīva medikamentozā terapija, kas apturētu slimības progresiju. Šī darba mērķis bija noskaidrot, vai no zoba pulpas cilmes šūnām izolētas eksosomas reversē gaitas izmaiņas 6-hidroksidopamīna (6-OHDA) inducētā Pārkinsona slimības modelī žurkās, kā arī noskaidrot, vai pēc eksosomu lietošanas pārtraukšanas ir novērojams ilgtermiņa gaitu normalizējošs efekts. Gaitas izmaiņu noteikšanai tika veikts CatWalk XT automatizētais gaitas tests. Darbā iegūtie dati ļauj se…
Neuroprotective Properties of Mildronate, a Small Molecule, in a Rat Model of Parkinson’s Disease
2010
Previously, we have found that mildronate [3-(2,2,2-trimethylhydrazinium) propionate dihydrate], a small molecule with charged nitrogen and oxygen atoms, protects mitochondrial metabolism that is altered by inhibitors of complex I and has neuroprotective effects in an azidothymidine-neurotoxicity mouse model. In the present study, we investigated the effects of mildronate in a rat model of Parkinson’s disease (PD) that was generated via a unilateral intrastriatal injection of the neurotoxin 6-hydroxydopamine (6‑OHDA). We assessed the expression of cell biomarkers that are involved in signaling cascades and provide neural and glial integration: the neuronal marker TH (tyrosine hydroxylase); …
No zoba pulpas cilmes šūnas izolētas eksosoma ievadītas intranazāli protektē dopamīnerģiskos neironus 6-OHDA izraisītā Pārkinsona slimības modelī žur…
2018
Pārkinsona slimība (PS) ir viena no visbiežāk sastopamajām neirodeģeneratīvajām saslimšanām, kurai joprojām nav atrasta efektīva medikamentoza terapija. Slimnieku skaits ar katru gadu pieaug, jo aizvien ir apgrūtināta savlaicīga slimības diagnosticēšana un ārstēšana. Pirmos PS simptomus novēro, kad lielākajā smadzeņu daļā jau ir notikusi dopamīnerģisko neironu atrofija. Darba mērķis bija noskaidrot eksosomu protekciju uz dopamīnerģiskajiem neironiem un to ietekmi uz motorajiem traucējumiem un salīdzināt kā no zoba pulpas cilmes šūnā iegūtas eksosomas spēj protektēt neirotoksīna 6-OHDA izraisītus bojājumus žurku smadzenēs. noskaidrot vai intranazāli ievadītas eksosomas, izolētas no zoba pulp…