Search results for "610"
showing 10 items of 1353 documents
The role of SAXS and molecular simulations in 3D structure elucidation of a DNA aptamer against lung cancer
2021
Aptamers are short, single-stranded DNA or RNA oligonucleotide molecules that function as synthetic analogs of antibodies and bind to a target molecule with high specificity. Aptamer affinity entirely depends on its tertiary structure and charge distribution. Therefore, length and structure optimization are essential for increasing aptamer specificity and affinity. Here, we present a general optimization procedure for finding the most populated atomistic structures of DNA aptamers. Based on the existed aptamer LC-18 for lung adenocarcinoma, a new truncated LC-18 (LC-18t) aptamer LC-18t was developed. A three-dimensional (3D) shape of LC-18t was reported based on small-angle X-ray scattering…
Influence of Oral Health Care Systems on Future Career Environment of Dental Students in Europe
2021
Oral healthcare is organized subsidiarily and independently by nation states in Europe and also within the EU and consequently, major differences between the nation states and the various oral healthcare systems in Europe are present. The socialization in the respective catchment area can have an impact on the job choice and the perception of employment opportunities of different professional groups. Therefore, the purpose of this survey was to elucidate the influence of different oral healthcare systems on students living or studying in the respective catchment area. A questionnaire (in English, French, German, Italian, and Spanish) with 18 different components was administered. Data on ge…
EVAR IN OUT CLINIC PATIENTS: IS IT FEASIBLE AND SAFE?
2013
Introduction Only little is known about endovascular aneurysm repair (EVAR) performed as an outpatient procedure. We report here a two-center (Middelares Hospital, Antwerp (Deurne), Belgium and University Hospital Zurich, Switzerland) experience in 104 EVAR patients of which a group of 52 patients have been treated on an outpatient (out-EVAR) basis and compared to a matched group of 52 patients that have been treated as inpatients (in-EVAR). Methods Selection criterions for out-EVAR were: informed consent, travel time to the hospital if readmission was required of <30-60 minutes, and technically uncomplicated EVAR. Most out-EVAR has been treated percutaneous. In-EVAR patients consisted in a…
COVID-SCORE Spain: public perceptions of key government COVID-19 control measures
2021
Abstract Background Spain was initially one of the countries most affected by the coronavirus disease 2019 (COVID-19) pandemic. In June 2020, the COVID-SCORE-10 study reported that the Spanish public’s perception of their government’s response to the pandemic was low. This study examines these perceptions in greater detail. Methods We employed an ordered logistic regression analysis using COVID-SCORE-10 data to examine the Spanish public’s perception of 10 key aspects of their government’s COVID-19 control measures. These included support for daily needs, mental and general health services, communication, information and coordination, which were examined by gender, age, education level, hav…
The PANDA Endcap Disc DIRC
2018
Journal of Instrumentation 13(02), C02002 - C02002 (2018). doi:10.1088/1748-0221/13/02/C02002
The importance of psychological variables in the perceived exertion of young football players
2017
Las escalas para medir la percepción del esfuerzo están entre los métodos que han sido utilizados para el control y la evaluación de la carga interna del entrenamiento en deportes de equipo como el fútbol. Debido a su naturaleza psicofisiológica, su registro proporciona información proveniente tanto de indicadores fisiológicos como psicológicos del deportista. Dentro del marco de la Teoría de la Autodeterminación (SDT, Self Determination Theory; Deci & Ryan, 1985; Ryan & Deci, 2017) y de la Teoría de las Metas de Logro (AGT, Achievement Goal Theory; Ames, 1992; Nicholls, 1989), en esta tesis doctoral se estudian tanto las variables contextuales desadaptativas (dimensiones del clima motivaci…
Polymorphic chiral squaraine crystallites in textured thin films
2020
Chirality 32(5), 619 - 631 (2020). doi:10.1002/chir.23213
Mathematics Competence Level: The Contribution of Non-symbolic and Spatial Magnitude Comparison Skills.
2019
Magnitude comparison skills have been related to mathematics competence, although results in this area vary. The current study aimed to describe the performance of 75 children (aged 4-5 years) in two comparison tasks; and examine the strength of the relationship between each of the two tasks and mathematics competence level (MCL). Participants were assessed with the Early Numeracy Test which provides a global MCL score. Magnitude comparison skills were assessed with two tasks: a non-symbolic number comparison task and a spatial comparison task. Results of the Pearson correlation analysis showed a relationship between the two tasks with better performance in the spatial comparison task. Regr…
Duelo: Factores de riesgo de duelo complicado en cuidados paliativos
2015
Duelo:Factores de riesgo de duelo complicado en cuidados paliativos Antecedentes Tradicionalmente, los factores de riesgo de duelo complicado no han sido evaluados en el ámbito de los cuidados paliativos, y aún menos, estudiados todos los factores de riesgo simultáneamente. Un objetivo principal podría ser el diagnóstico temprano de riesgo de duelo complicado y, de esta manera, evitar a los cuidadores primarios la cronificación de sus trastornos físicos y psicológicos, aún más, la muerte de una persona significativamente relevante es un fuerte predictor de mortalidad (Christakis & Allison, 2007; Schmidpeter, 2015). Prigerson & Jacobs (2001) propusieron el segundo mes después del fallecimien…
Value of Combined PET Imaging with [18F]FDG and [68Ga]Ga-PSMA-11 in mCRPC Patients with Worsening Disease during [177Lu]Lu-PSMA-617 RLT
2021
Despite the promising results of prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) in metastatic castration-resistant prostate cancer (mCRPC), some patients show worsening disease during PSMA-RLT. We investigated the value of combined [18F]FDG and [68Ga]Ga-PSMA-11 PET imaging in this setting. In n = 29 mCRPC patients with worsening disease after a median of four cycles of [177Lu]Lu-PSMA-617 RLT, combined [18F]FDG and [68Ga]Ga-PSMA-11 PET imaging was performed to detect [18F]FDG-avid lesions with low or no PSMA expression (mismatch lesions). To evaluate prognostic implication of mismatch, survival analyses regarding presence, location, and [18F]FDG PET-derived para…