Search results for "615"
showing 10 items of 128 documents
Desertions in nineteenth-century shipping: modelling quit behaviour
2013
Ship jumping in foreign ports was widespread throughout the age of sail. Desertion by seamen was illegal, it occurred abroad, and men who deserted only seldom returned home. We analyse desertion quantitatively and link it to the broader question of quit behaviour and labour turnover. Though the better wages paid at the foreign ports were the main reason for desertion, the regression model of the determinants of desertion indicates that outside opportunities, such as migration, and monetary incentives played a significant role in the nineteenth-century labour market, characterized by rather strict control over labour supply, working conditions, and terms of trade. Copyright , Oxford Universi…
Actividad antimicrobiana in vitro de nuevas 6-fluoroquinolonas de administración por vía oral. Relación estructura-actividad
2002
Las fluoroquinolonas se han convertido en agentes importantes en quimioterapia, especialmente en pacientes con infecciones graves que requieran fármacos potentes administrados por vía oral. Sin embargo, la aparición de resistencias a las quinolonas ha conducido a la búsqueda de nuevas moléculas, principalmente incluyendo modificaciones en el núcleo base de la benzopiridona, lo que ha llevado al hallazgo y comercialización de nuevas quinolonas, más activas pero, en muchos casos, más tóxicas, hasta el punto de que algunas han dejado de utilizarse o han sido retiradas del mercado tras haberse demostrado su peligrosidad a medio o largo plazo.En este contexto, el ciprofloxacino es una de las qui…
The concept of the Royal Prerogative in parliamentary debates on the deployment of military in the British House of Commons, 1982–2003
2014
The article will discuss how one political key concept, the Royal Prerogative, was discussed in the British House of Commons in relation to the right to deploy and use armed troops abroad during the period 1982-2003, a time when the role of the British Parliament in decisions to deploy and commit troops to an armed conflict abroad was under extensive discussion in Parliament. This discussion began increasingly to address the state of the constitutional arrangements, more specifically the redefinition of the Royal Prerogative rights, the residual powers of the executive, as outdated in the understanding of modern representative democracy. The use of the concept was studied to reveal the atti…
Let the best story win : evaluation of the most cited business history articles
2017
Faced with intensifying competition for scientific impact measured in terms of citation counts, small disciplines are challenged to prove their importance as they lack the critical mass to accumulate large numbers of citations. This paper demonstrates that by emphasizing theoretical and methodological rigor even small disciplines such as business history can be competitive. Yet it still appears that readers of business history articles first and foremost seek interesting and useful subject matter, i.e. ‘best’ stories that can be used as background information and as tools in comparisons. However, articles advancing theory and methodology have increasingly gained interest and citations from …
Explanations of success and failure in management learning : What can we learn from Nokia's rise and fall
2016
International audience; In this paper, we study the changing explanations of success and failure over the course of a firm's history. We build on a discursive approach that highlights the role of narrative attributions in making sense of corporate performance. Specifically, we analyze how the Nokia Corporation was framed first as a success and later as a failure and how these dimensions of performance were explained in various actors' narrative accounts. In both the success and failure accounts, our analysis revealed a striking black-and-white picture that resulted in the institutionalization of Nokia's metanarratives of success and failure. Our findings also reveal a number of discursive a…
Impacto del uso de tecnologías no térmicas sobre distintos parámetros nutricionales y de calidad en alimentos líquidos / Non-thermal technologies imp…
2011
In the last decade have appeared in the Spanish market new products based on mixtures of fruit juices and milk as well as beverages mixtures of fruit and/or vegetables, which have a good acceptance by consumers and with a high nutritional value largely due to its high content in bioactive compounds as well as antioxidant capacity. Traditionally, liquid food such as fruit and/or vegetables juices, as well as milk, have been preserved by thermal treatment such as pasteurization and sterilization. However these processes can cause loss of compounds responsible for the organoleptic and nutritional quality of food. Currently there is a growing demand by the consumer for minimally processed food …
Controlled Iontophoretic Delivery in Vitro and in Vivo of ARN14140—A Multitarget Compound for Alzheimer’s Disease
2019
ARN14140 is a galantamine-memantine conjugate that acts upon both cholinergic and glutamatergic pathways for better management of Alzheimer's disease. Poor oral bioavailability and pharmacokinetics meant that earlier preclinical in vivo studies employed intracerebroventricular injection to administer ARN14140 directly to the brain. The aim of the present study was to evaluate the feasibility of using constant current transdermal iontophoresis for the noninvasive systemic delivery of ARN14140 and to quantify the amounts present in the blood and the brain. Preliminary experiments in vitro were performed using porcine skin and validated with human skin. Cumulative ARN14140 permeation across th…
Iontophoresis: electrorepulsion and electroosmosis.
2000
Over the last 10-15 years, the electrical enhancement of drug delivery across the skin has undergone intense investigation. During this period, considerable amounts of experimental data have been generated, and the successful enhancement of a diverse array of molecules has been achieved. Indeed, the commercial exploitation of the method can be envisaged within the next few years. Despite this progress, however, the mechanistic understanding of iontophoresis remains a challenging scientific question that is yet to be fully resolved. The routes of permeation under the influence of an applied electrical potential, and the molecular interactions of the transporting drug with these pathways, hav…
Farewell to Anarchy : The Myth of International Anarchy and Birth of Anarcophilia in International Relations
2018
This article scrutinizes the conceptual history of international anarchy. The argument purported here is that even though the idea of international anarchy is often seen as very central for the academic discipline of international relations, the concept is in fact not found from the forerunners or classics of the discipline. The assumption of international anarchy is commonly seen as a defining feature of a Realist school of international relations. Yet, the concept and especially its “Realist” implications are not to be found in the classics of Realism, from Thucydides, Machiavelli or Hobbes. The idea of “international anarchy” emerges quite tentatively during the First World War, in the w…
Of Walls and Fences: Brexit and the History of Cross-Border Migration
2019
Champions of Brexit have employed a large arsenal of arguments to boost their case for a Britain better off on its own, freed from its current European entanglements. All kinds of supposed ills have been linked to the country’s EU membership in British public debates over the years, ranging from petty bureaucratic absurdities, such as directives regarding crooked bananas, to heavy-handed rulings on higher matters of domestic and foreign policy. Lamentations about continental meddling have been accompanied by grand, nostalgic visions of an unfettered future Great Britain, ready to return to its proper, independent role on the global stage once it manages to cast off the shackles imposed by B…