Search results for "615"
showing 10 items of 128 documents
Modelado farmacocinético de ciclofosfamida en pacientes con cáncer de mama.
2009
El objetivo principal es establecer un modelo estructural farmacocinético poblacional, en pacientes con cáncer de mama de alto riesgo tratados con ciclofosfamida a dosis altas, para predecir su respuesta individual.Los objetivos Secundarios son explorar mecanismos fisiológicos condicionantes de la autoinducción metabólica de ciclofosfamida. Detección de subpoblaciones de pacientes a través de parámetros de eliminación de ciclofosfamida. Plantear la influencia de covariables, a través del análisis exploratorio, sobre los valores centrales de los parámetros farmacocinéticos de ciclofosfamida.La población de estudio está compuesta por pacientes atendidas en el Hospital Clínico Universitario y …
Tabaco, estrés oxidativo e inflamación en vías aéreas. Papel del AMPc.
2010
La Enfermedad Pulmonar Obstructiva Crónica (EPOC) es una patología caracterizada por una obstrucción progresiva irreversible de las vías aéreas cuya causa principal es el humo de tabaco. Una característica distintiva de esta enfermedad es la hipersecreción mucosa; además, el estrés oxidativo está implicado en este proceso. En dicho estés oxidativo juega un papel muy importante el complejo NADPH oxidasa. En esta tesis, se planteó el caracterizar los mecanismos por los que la activación del complejo NADPH oxidasa mediada por tabaco conducían a la hipersecreción mucosa, estudiando la implicación del AMPc en dicho proceso. Los resultados muestran que el tabaco activa el complejo NADPH oxidasa, …
Aspectos farmacocinéticos y farmacodinámicos de la administración de bupivacaína y ropivacaína en el plexo lumbar y nervio ciático en cirugía ortopéd…
2010
INTRODUCCIÓN Los anestésicos locales (AL) son empleados en las técnicas de anestesia locoregional por su capacidad de bloquear la conducción de impulsos nerviosos, de modo que la función sensitiva o motora de las fibras nerviosas queda inhibida transitoriamente. Estas técnicas locoregionales pueden utilizarse como técnica única o en combinación con anestesia general. El bloqueo combinado del plexo lumbar (PL) y del nervio ciático (NC) para cirugía ortotraumática de miembros inferiores es la modalidad de elección frente a la anestesia espinal y general. Existen pocos estudios referentes a la administración de mezclas de AL de acción prolongada. Para el adecuado desarrollo de la técnica anest…
Transformaciones recientes en el área metropolitana de Valencia. Evolución de los usos del suelo en el municipio de Torrent (1956-2011)
2016
Report of the Scientific Committee of the Spanish Agency for Food Safety and Nutrition (AESAN) on the presence and safety of plastics as contaminants…
2020
* This record is given in both English and Spanish. The use of plastics is widespread in both industry and domestic life as food packaging material and as a material that comes into contact with food. Therefore, plastics and their environmental impact, especially in the marine environment, arouse great interest and concern. Microplastics have been the focus of most of the studies carried out so far due to their growing presence in the natural environment and their potential to be transferred between trophic levels. It is necessary not only to make an exhaustive assessment of the presence of microplastics in the environment and food, but also of their effects on human’s health. This report a…
Teaching Archaeological Heritage Management: Towards a Change in Paradigms
2018
The concept of archaeological heritage management (AHM) has been key to wider archaeological research and preservation agendas for some decades. Many universities and other education providers now offer what is best termed heritage management education (HME) in various forms. The emphasis is commonly on archaeological aspects of heritage in a broad sense and different terms are often interchangeable in practice. In an innovative working-conference held in Tampere, Finland, we initiated a debate on what the components of AHM as a course or curriculum should include. We brought together international specialists and discussed connected questions around policy, practice, research and teaching/…
The Lupa Romana in the Roman provinces
2014
The she-wolf with the twins, Romulus and Remus, was identified as a symbol of Rome by both the Romans themselves and nations under the Roman rule. In this essay I will discuss the Lupa Romana in Roman provincial art. I will present various visual representations of the she-wolf both in the public use and in objects related to private life, and analyze the she-wolf’s symbolic meaning.The Lupa Romana was an iconic scene that was not used randomly in provincial art. It represented in the first place the idea of romanitas, being Roman. In some cases the use of the symbol could have been in consequence of instructions from Rome itself or from provincial authorities that depended on Rome, but in …
Jeffrey Herf. Undeclared Wars with Israel : East Germany and the West German Far Left, 1967–1989.
2018
Taking historical embeddedness seriously : Three historical approaches to advance strategy process and practice research
2016
International audience; Despite the proliferation of strategy process and practice research, we lack understanding of the historical embeddedness of strategic processes and practices. In this paper, we present three historical approaches with the potential to remedy this deficiency. First, realist history can contribute to a better understanding of the historical embeddedness of strategic processes; in particular, comparative historical analysis can explicate the historical conditions, mechanisms, and causality in strategic processes. Second, interpretative history can add to our knowledge of the historical embeddedness of strategic practices, and microhistory can specifically help to under…
Europe and refugees : 1938 and 2015-16
2018
Ahonen attempts to provide some historical contextualization for the refugee crisis that has dominated much of European public and political debate since 2015. He draws comparisons between the crisis-ridden present and the decade of the previous century that was particularly laden with anticipation of disaster and doom: the 1930s. More specifically, his article explores parallels in public discussions of refugees by European political leaders and media commentators in 1938, on the one hand, and 2015–16, on the other. The coverage of 1938 focuses on the Evian Conference, organized to discuss the problem of Jewish refugees from Nazi Germany, while the analysis of 2015–16 concerns the period f…