Search results for "61"
showing 10 items of 3634 documents
It's Sad but I Like It The Neural Dissociation Between Musical Emotions and Liking in Experts and Laypersons
2016
Emotion-related areas of the brain, such as the medial frontal cortices, amygdala, and striatum, are activated during listening to sad or happy music as well as during listening to pleasurable music. Indeed, in music, like in other arts, sad and happy emotions might co-exist and be distinct from emotions of pleasure or enjoyment. Here we aimed at discerning the neural correlates of sadness or happiness in music as opposed those related to musical enjoyment. We further investigated whether musical expertise modulates the neural activity during affective listening of music. To these aims, 13 musicians and 16 non-musicians brought to the lab their most liked and disliked musical pieces with a …
The pleasure evoked by sad music is mediated by feelings of being moved
2017
Why do we enjoy listening to music that makes us sad? This question has puzzled music psychologists for decades, but the paradox of “pleasurable sadness” remains to be solved. Recent findings from a study investigating the enjoyment of sad films suggest that the positive relationship between felt sadness and enjoyment might be explained by feelings of being moved (Hanich et al., 2014). The aim of the present study was to investigate whether feelings of being moved also mediated the enjoyment of sad music. In Experiment 1, 308 participants listened to five sad music excerpts and rated their liking and felt emotions. A multilevel mediation analysis revealed that the initial positive relations…
Limitacions educatives del teatre escolar tradicional : reflexions i propostes escèniques alternatives
2014
En primer lloc, aquesta investigació s’endinsa en una reflexió sobre el teatre escolar tradicional per mostrar les diferents limitacions de caràcter educatiu que presenten aquestes pràctiques a l’escola. Posteriorment, la recerca planteja diferents propostes i estratègies metodològiques amb l’objectiu de resoldre aquestes limitacions. La investigació està fonamentada en l’ampla experiència personal del seu autor envers el teatre escolar i el gran nombre i varietat de muntatges teatrals realitzats, que serveixen de proves documentals per reforçar les hipòtesis que plantegem a la investigació.
Differential influence of vemurafenib and dabrafenib on patient lymphocytes despite similar clinical efficacy in melanoma
2014
Background: Since the majority of melanomas eventually become resistant and progress, combining selective BRAF inhibitors (BRAFi) with immunotherapies has been proposed to achieve more durable treatment responses. Here, we explored the impact of selective BRAFi on the hosts’ immune system. Patients and methods: Clinical data, whole blood counts (WBC) and serum lactate dehydrogenase (LDH) of 277 vemurafenib- and 65 dabrafenib-treated melanoma patients were evaluated. The frequency and phenotype of lymphocyte subpopulations were determined by flow cytometry while T cell cytokine secretion was measured by multiplex assays. Results: Progression-free survival (PFS) as well as overall survival (O…
Mutant HRAS as novel target for MEK and mTOR inhibitors.
2015
HRAS is a frequently mutated oncogene in cancer. However, mutant HRAS as drug target has not been investigated so far. Here, we show that mutant HRAS hyperactivates the RAS and the mTOR pathway in various cancer cell lines including lung, bladder and esophageal cancer. HRAS mutation sensitized toward growth inhibition by the MEK inhibitors AZD6244, MEK162 and PD0325901. Further, we found that MEK inhibitors induce apoptosis in mutant HRAS cell lines but not in cell lines lacking RAS mutations. In addition, knockdown of HRAS by siRNA blocked cell growth in mutant HRAS cell lines. Inhibition of the PI3K pathway alone or in combination with MEK inhibitors did not alter signaling nor had an imp…
Aikuisten maahanmuuttajien kotoutumiskoulutuksen tulosten ennustaminen lähtötason arviointien perusteella
2017
Artikkelissa selvitetään aikuisten maahanmuuttajien kotoutumiskoulutuksessa saavuttamaa suomen kielen taitoa ja sitä, ennustaako koulutuksen alussa tehtävä lähtötason arviointi saavutettua kielitaitoa. Tutkimukseen osallistuneet maahanmuuttajat (N = 286) osallistuivat lähtötason arviointiin Testipisteessä. Sen jälkeen he suorittivat kotoutumiskoulutuksen opinnot peruspolun tai hitaan opintopolun mukaisesti muutamassa pääkaupunkiseudun oppilaitoksessa. Testipisteen mallin mukaisessa lähtötason arvioinnissa selvitetään maahanmuuttajan suomen kielen taitoa ja opiskeluvalmiuksia testeillä ja taustatietoja keräämällä. Niiden pohjalta maahanmuuttaja ohjataan sopivimmalle opintopolulle ja kielitai…
Monitieteistä tutkimusta mestari Franckesta
2018
Arvio teoksesta Ulrike Nürnberger, Elina Räsänen & Uwe Albrecht (toim.), Meister Francke Revisited: Auf den Spuren eines Hamburger Malers (Petersberg: Michael Imhof Verlag, 2017).
Estrategias empresariales en el territorio : El caso del mueble valenciano
2020
El territorio y las aglomeraciones de empresas son factores que cada vez suscitan mayor interés en las teorías de la organización. En el estudio que aquí se presenta se aborda el análisis de un conglomerado específico: el del mueble valenciano, su expansión a lo largo del siglo XX y su declive tras las crisis de la globalización y del consumo. Se evidencian las conexiones y complementariedades entre empresas y cómo la cooperación puede ser más importante que la rivalidad en un mercado competitivo. Los factores de contingencia y las crisis tienen una incidencia diferencial en las empresas según el segmento en que se encuentren, pero también, en función de las estrategias que adopten. Por ell…
Automatic Processing of Changes in Facial Emotions in Dysphoria: A Magnetoencephalography Study
2018
It is not known to what extent the automatic encoding and change detection of peripherally presented facial emotion is altered in dysphoria. The negative bias in automatic face processing in particular has rarely been studied. We used magnetoencephalography (MEG) to record automatic brain responses to happy and sad faces in dysphoric (Beck’s Depression Inventory ≥ 13) and control participants. Stimuli were presented in a passive oddball condition, which allowed potential negative bias in dysphoria at different stages of face processing (M100, M170, and M300) and alterations of change detection (visual mismatch negativity, vMMN) to be investigated. The magnetic counterpart of the vMMN was el…
Spatiotemporal dynamics of activation in motor and language areas suggest a compensatory role of the motor cortex in second language processing
2023
The involvement of the motor cortex in language understanding has been intensively discussed in the framework of embodied cognition. Although some studies have provided evidence for the involvement of the motor cortex in different receptive language tasks, the role that it plays in language perception and understanding is still unclear. In the present study, we explored the degree of involvement of language and motor areas in a visually presented sentence comprehension task, modulated by language proficiency (L1: native language, L2: second language) and linguistic abstractness (literal, metaphorical, and abstract). Magnetoencephalography data were recorded from 26 late Chinese learners of …