Search results for "63"

Zvaigžņotā Debess: 2013, Vasara (220)

2013

Saturs: Pēdējā "Apollo" ekspedīcija uz Mēnesi ; Vissavienības Astronomijas un ģeodēzijas biedrības Latvijas nodaļa ; M.Gills. ESON – astronomijas popularizēšanas tīkls ; S.Kropa. Dvēsele Atakamas tuksnesī ; M.G. Īsumā: ESO Astro Camp Eiropas vidusskolēniem 2013.gada decembrī ; A.Alksnis. Atklāta vēl viena no Saulei vistuvākajām kaimiņzvaigznēm ; A.Alksnis. Tuvēja zvaigzne, kas ir izveidojusies jau drīz pēc Lielā Sprādziena ; A.Alksnis. Čeļabinskas superbolīds – simtgades notikums ; A.Alksnis. Nevis pārsteidzoša nova, bet gan kvazāra uzliesmojums ; I.Eglītis. Orius – Baldones observatorijā atklātais centaurs ; R.Misa. Denisa Tito Marsa iedvesmas fonds ; A.A. Īsumā: Ap zvaigzni Gleznotāja Bet…

Morphological characterisation of soil structure in tilled fields: from a diagnosis method to the modelling of structural changes over time

2004

Characterisation of soit structure within the tilled layer of cultivated fields is crucial because the importance of this soil characteristic on the biological, chemical and physical properties of the soil and its repercussions on water cycle, root growth and functioning. We present in this paper a method for field characterisation of soil structure. This method, practised since the 1970s, was designed for field diagnosis of the effects of cropping systems on soil structure. It is based on a stratification of the observation face of a pit dug perpendicular to the direction of tillage and traffic: spatial compartments are distinguished, according to the nature of the mechanical stresses they…

miR-205-5p-mediated downregulation of ErbB/HER receptors in breast cancer stem cells results in targeted therapy resistance

2015

AbstractThe ErbB tyrosine kinase receptor family has been shown to have an important role in tumorigenesis, and the expression of its receptor members is frequently deregulated in many types of solid tumors. Various drugs targeting these receptors have been approved for cancer treatment. Particularly, in breast cancer, anti-Her2/EGFR molecules represent the standard therapy for Her2-positive malignancies. However, in a number of cases, the tumor relapses or progresses thus suggesting that not all cancer cells have been targeted. One possibility is that a subset of cells capable of regenerating the tumor, such as cancer stem cells (CSCs), may not respond to these therapeutic agents. Accumula…

A pan-cancer analysis shows immunoevasive characteristics in NRF2 hyperactive squamous malignancies

2023

The NRF2 pathway is frequently activated in various cancer types, yet a comprehensive analysis of its effects across different malignancies is currently lacking. We developed a NRF2 activity metric and utilized it to conduct a pan-cancer analysis of oncogenic NRF2 signaling. We identified an immunoevasive phenotype where high NRF2 activity is associated with low interferon-gamma (IFNγ), HLA-I expression and T cell and macrophage infiltration in squamous malignancies of the lung, head and neck area, cervix and esophagus. Squamous NRF2 overactive tumors comprise a molecular phenotype with SOX2/TP63 amplification, TP53 mutation and CDKN2A loss. These immune cold NRF2 hyperactive diseases are a…

Comment on “Worldwide Distribution of PK Deficiency: the Defect Seems Mainly Concentrated in West African Countries and the United States.”

2021

Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation

2021

Abstract Background Little is known about characteristics of seasonal human coronaviruses (HCoVs) (NL63, 229E, OC43, and HKU1) after allogeneic stem cell transplantation (allo-HSCT). Methods This was a collaborative Spanish and European bone marrow transplantation retrospective multicenter study, which included allo-HSCT recipients (adults and children) with upper respiratory tract disease (URTD) and/or lower respiratory tract disease (LRTD) caused by seasonal HCoV diagnosed through multiplex polymerase chain reaction assays from January 2012 to January 2019. Results We included 402 allo-HSCT recipients who developed 449 HCoV URTD/LRTD episodes. Median age of recipients was 46 years (range,…

Nuevas pinturas europeas en el MOBAT (Chile)

2018

El MOBAT es uno de los espacios culturales más significados de Chile, por la historia que envuelve su emblemático edificio como por la cantidad y calidad de obras artísticas y piezas históricas que atesora. Sin embargo, desde el terremoto de 2010, permanece cerrado al público y pendiente de ser restaurado y rehabilitado. En este trabajo completamos otros estudios anteriormente publicados sobre la colección de pintura europea que el museo alberga entre sus muros. The MOBAT is one of the most significant cultural spaces in Chile, due to the history that surrounds its emblematic building as well as the quantity and quality of artistic works and historical pieces that it treasures. However, sin…

Fama posthuma a la vida y muerte del doctor frey Lope Felix de Vega Carpio y elogios panegiricos a la inmortalidad de sv nombre / escritos por los ma…

1636

Sign.: œ8, œœ4, A-Z8, Aa-Cc8, Dd4 Errates tip. a la fol. Port. orlada Escut xill. del Duc de Sesa a la f. [7

Strain gradient elasticity within the symmetric BEM formulation

2014

The symmetric Galerkin Boundary Element Method is used to address a class of strain gradient elastic materials featured by a free energy function of the (classical) strain and of its (first) gradient. With respect to the classical elasticity, additional response variables intervene, such as the normal derivative of the displacements on the boundary, and the work-coniugate double tractions. The fundamental solutions - featuring a fourth order partial differential equations (PDEs) system - exhibit singularities which in 2D may be of the order 1/ r 4 . New techniques are developed, which allow the elimination of most of the latter singularities. The present paper has to be intended as a resear…

IL-22 is produced by innate lymphoid cells and limits inflammation in allergic airway disease

2011

Interleukin (IL)-22 is an effector cytokine, which acts primarily on epithelial cells in the skin, gut, liver and lung. Both pro- and anti-inflammatory properties have been reported for IL-22 depending on the tissue and disease model. In a murine model of allergic airway inflammation, we found that IL-22 is predominantly produced by innate lymphoid cells in the inflamed lungs, rather than TH cells. To determine the impact of IL-22 on airway inflammation, we used allergen-sensitized IL-22-deficient mice and found that they suffer from significantly higher airway hyperreactivity upon airway challenge. IL-22-deficiency led to increased eosinophil infiltration lymphocyte invasion and production…