Search results for "65"
showing 10 items of 1111 documents
Visceral Adiposity Index: An Indicator of Adipose Tissue Dysfunction
2013
The Visceral Adiposity Index (VAI) has recently proven to be an indicator of adipose distribution and function that indirectly expresses cardiometabolic risk. In addition, VAI has been proposed as a useful tool for early detection of a condition of cardiometabolic risk before it develops into an overt metabolic syndrome. The application of the VAI in particular populations of patients (women with polycystic ovary syndrome, patients with acromegaly, patients with NAFLD/NASH, patients with HCV hepatitis, patients with type 2 diabetes, and general population) has produced interesting results, which have led to the hypothesis that the VAI could be considered a marker of adipose tissue dysfuncti…
Vitamin D and Osteoporosis in HIV/HCV Coinfected Patients: A Literature Review
2015
Vitamin D deficiency further increases the risk of osteoporosis in HIV-positive patients coinfected with hepatitis C virus (HCV); however, it is still unclear whether HCV-related increased fracture risk is a function of the severity of liver disease. The aim of this review was to identify studies on associative vitamin D deficiency patterns in high-risk populations such as HIV/HCV coinfected patients. We did this by searching MEDLINE and EMBASE databases, from inception to August 2014, and included bibliographies. The final 12 articles selected are homogeneous in terms of age but heterogeneous in terms of sample size, participant recruitment, and data source. Most of the HIV/HCV coinfected …
Observational constraints on inhomogeneous cosmological models without dark energy
2011
It has been proposed that the observed dark energy can be explained away by the effect of large-scale nonlinear inhomogeneities. In the present paper we discuss how observations constrain cosmological models featuring large voids. We start by considering Copernican models, in which the observer is not occupying a special position and homogeneity is preserved on a very large scale. We show how these models, at least in their current realizations, are constrained to give small, but perhaps not negligible in certain contexts, corrections to the cosmological observables. We then examine non-Copernican models, in which the observer is close to the center of a very large void. These models can gi…
Hypoxia Positively Regulates the Expression of pH-Sensing G-Protein–Coupled Receptor OGR1 (GPR68)
2016
Background & Aims: A novel family of proton-sensing G-proteinâcoupled receptors, including ovarian cancer G-proteinâcoupled receptor 1 (OGR1) (GPR68) has been identified to play a role in pH homeostasis. Hypoxia is known to change tissue pH as a result of anaerobic glucose metabolism through the stabilization of hypoxia-inducible factor-1α. We investigated how hypoxia regulates the expression of OGR1 in the intestinal mucosa and associated cells. Methods: OGR1 expression in murine tumors, human colonic tissue, and myeloid cells was determined by quantitative reverse-transcription polymerase chain reaction. The influence of hypoxia on OGR1 expression was studied in monocytes/macrophages and…
Weak and strong convergence of an inertial proximal method for solving bilevel monotone equilibrium problems
2022
In this paper, we introduce an inertial proximal method for solving a bilevel problem involving two monotone equilibrium bifunctions in Hilbert spaces. Under suitable conditions and without any restrictive assumption on the trajectories, the weak and strong convergence of the sequence generated by the iterative method are established. Two particular cases illustrating the proposed method are thereafter discussed with respect to hierarchical minimization problems and equilibrium problems under saddle point constraint. Furthermore, a numerical example is given to demonstrate the implementability of our algorithm. The algorithm and its convergence results improve and develop previous results i…
Does social climate influence positive eWOM? A study of heavy-users of online communities.
2018
Abstract This paper provides a deeper understanding of the role of social influences on positive eWOM behaviour (PeWOM) of heavy-users of online communities. Drawing on Social Interaction Utility Framework, Group Marketing and Social Learning Theories, we develop and test a research model integrating the interactions between the social climate of a website and Interpersonal Influences in PeWOM. 262 Spanish heavy-users of online communities were selected and the data analysed using partial least squares equation modelling. Overall, the model explains 59% of the variance of PeWOM on online communities. Findings reveal that interaction with other members of the online community (Social Presenc…
Towards Stable Radial Basis Function Methods for Linear Advection Problems
2021
In this work, we investigate (energy) stability of global radial basis function (RBF) methods for linear advection problems. Classically, boundary conditions (BC) are enforced strongly in RBF methods. By now it is well-known that this can lead to stability problems, however. Here, we follow a different path and propose two novel RBF approaches which are based on a weak enforcement of BCs. By using the concept of flux reconstruction and simultaneous approximation terms (SATs), respectively, we are able to prove that both new RBF schemes are strongly (energy) stable. Numerical results in one and two spatial dimensions for both scalar equations and systems are presented, supporting our theoret…
A sequence motif enriched in regions bound by the Drosophila dosage compensation complex
2010
Abstract Background In Drosophila melanogaster, dosage compensation is mediated by the action of the dosage compensation complex (DCC). How the DCC recognizes the fly X chromosome is still poorly understood. Characteristic sequence signatures at all DCC binding sites have not hitherto been found. Results In this study, we compare the known binding sites of the DCC with oligonucleotide profiles that measure the specificity of the sequences of the D. melanogaster X chromosome. We show that the X chromosome regions bound by the DCC are enriched for a particular type of short, repetitive sequences. Their distribution suggests that these sequences contribute to chromosome recognition, the genera…
Global patterns of sequence evolution in Drosophila.
2007
This article is available from: http://www.biomedcentral.com/1471-2164/8/408
Thermodynamic and Kinetic Modeling of Co-utilization of Glucose and Xylose for 2,3-BDO Production by Zymomonas mobilis
2021
Prior engineering of the ethanologen Zymomonas mobilis has enabled it to metabolize xylose and to produce 2,3-butanediol (2,3-BDO) as a dominant fermentation product. When co-fermenting with xylose, glucose is preferentially utilized, even though xylose metabolism generates ATP more efficiently during 2,3-BDO production on a BDO-mol basis. To gain a deeper understanding of Z. mobilis metabolism, we first estimated the kinetic parameters of the glucose facilitator protein of Z. mobilis by fitting a kinetic uptake model, which shows that the maximum transport capacity of glucose is seven times higher than that of xylose, and glucose is six times more affinitive to the transporter than xylose.…