Search results for "67"
showing 10 items of 1313 documents
Retinoic-Acid-Induced Downregulation of the 67 KDa Laminin Receptor Correlates with Reduced Biological Aggressiveness of Human Neuroblastoma Cells
2012
Neuroblastoma is a common tumor of the childhood arising from embryonal sympathetic neural cell precursors. Despite of the improved therapeutic strategies, the survival rate of high-risk neuroblastoma patients is poor. Although complete clinical remissions can be achieved, relapse is relatively frequent, indicating a role for the persistence of the minimal residual disease (for review, Maris, 2010). Treatments with derivatives of retinoic acid (RA), the biologically active form of vitamin A, produce significant improvements on the therapy of high-risk neuroblastoma patients, when used together with intensive multimodal therapies (Reynolds et al., 2003, for review). Despite some controversy …
Komētas 67P/Churyumov-Gerasimenko zemas kohēzijas daļiņu elektrostatiskā fragmentācija
2015
Pēc desmit ceļā pavadītiem gadiem un 2.5 gadiem pavadītiem hibernācijas periodā, Eiropas kosmosa aģentūras (angļu: European Space Agency, ESA) izpētes misija Rosetta uz komētu 67P/Churyumov-Gerasimenko ir pilnā datu ieguves režīmā, ar visiem tās 22 zinātniskajiem instrumentiem darbībā, lai izprastu mūsu Saules Sistēmas pirmsākumus. Komētas fizikālais raksturojums parāda, ka tās aptuvenais vidējais blīvums ir ~470 kg/m3 ar relatīvi mīkstu dabu un porozitāti no 70% līdz 80%. Šādām īpašībām apveltītas arī komētas mazākās daļiņas – putekļu graudi, ko parāda Rosettas COSIMA un MIDAS instrumenti - tām ir zema kohēzija tās viegli sadalās. Fizikālie procesi, kas iespējams apraksta šo sadalīšanos ir…
The Philae lander mission and science overview.
2017
The Philae lander accomplished the first soft landing and the first scientific experiments of a human-made spacecraft on the surface of a comet. Planned, expected and unexpected activities and events happened during the descent, the touch-downs, the hopping across and the stay and operations on the surface. The key results were obtained during 12–14 November 2014, at 3 AU from the Sun, during the 63 h long period of the descent and of the first science sequence on the surface. Thereafter, Philae went into hibernation, waking up again in late April 2015 with subsequent communication periods with Earth (via the orbiter), too short to enable new scientific activities. The science return of the…
Sublimation of icy aggregates in the coma of comet 67P/Churyumov–Gerasimenko detected with the OSIRIS cameras on board Rosetta
2016
Beginning in 2014 March, the OSIRIS (Optical, Spectroscopic, and Infrared Remote Imaging System) cameras began capturing images of the nucleus and coma (gas and dust) of comet 67P/Churyumov¿Gerasimenko using both the wide angle camera (WAC) and the narrow angle camera (NAC). The many observations taken since July of 2014 have been used to study the morphology, location, and temporal variation of the comet's dust jets. We analysed the dust monitoring observations shortly after the southern vernal equinox on 2015 May 30 and 31 with the WAC at the heliocentric distance Rh = 1.53 AU, where it is possible to observe that the jet rotates with the nucleus. We found that the decline of brightness a…
Martínez Calvo, Javier, El derecho al olvido digital como remedio frente a la hipermnesia de internet, Aranzadi, Cizur Menor (Navarra), 2021, 236 pp.
2021
Garantías legales del concepto de privacidad: Entre el derecho al olvido y el nuevo reglamento europeo de protección de datos
2018
The operation of new technologies and the supply of digital goods involves for users to disclose their personal data. The market data is already a reality with the danger that this entails for the privacy of citizens. The new General Data Protection Regulation has created a new legal framework that aims to radically change the current model, giving users greater powers to control their data. A good example of this is the express statement, and for the first time, of the right to be forgotten, which allows citizens to digitally erase their data when other fundamental rights are endangered.
Modulação gênica em embriões humanos
2018
O recente implemento de moderna tecnologia -CRISPR/Cas9- possibilitou o avanço inquestionável da edição gênica em linhagem germinativa humana, seja por meio da manipulação de células precursoras de gametas, células tronco pluripotentes, gametas ou, até mesmo, de embriões. Mesmo levando em conta os benefícios terapêuticos preventivos demonstrados nas pesquisas básicas e préclínicas em embriões humanos, tais investigações encontram barreiras de aceitação em todo o mundo. Tal situação exige mudança de atitude no sentido de incrementar o debate em torno da aplicabilidade dessas novas tecnologias. Assim, a adequação das atuais regulamentações faz-se necessária e deve incluir a superação dos desa…
La reproducción asistida y la filiación. Especial referencia al caso de las parejas de mujeres homosexuales
2018
This paper analyses, in general, the evolution that has had the art. 7.3 LTRHA since its introduction by the Act 3/2007, 15 march. In that way, it shows which has been the legislator´s solution about the use of assisted reproduction tecniques by homosexual women couples. Likewise, it studies which resolutions on the matter have been more relevant in the last years. All this, to set out the legislator´s failure and the need to reformulate the filiation regime in face of the challenge that assisted reproduction implies.
La incidencia de las malas relaciones entre los progenitores a la hora de acordar el régimen de guarda y custodia compartida. Análisis de la reciente…
2018
The relationship that the parents have with each other is one of the factors to take into consideration when adopting or not the modality of shared custody and custody after a situation of family crisis. To deny the shared modality if there was no good relationship between the parents was the rule until relatively recent dates. With the entry into force of local laws as well as the change in jurisprudence, the tendency that remains is to consider that it will no longer be enough that there is this bad relationship but will have to be a situation of high confrontation so that this situation may be grounds for denial of the shared custody regime.
Reflexiones a propósito de la protección de datos en el escenario global digital: El derecho de daños en la litigiosidad internacional
2021
La circulación internacional de datos personales constituye un sector pujante en la esfera socio-económica. En tales condiciones, ante la existencia de un tratamiento ilícito de aquellos, el agraviado está legitimado para exigir una indemnización por los daños y perjuicios que se hubieran podido originar en el marco transfronterizo. Tal situación plantea dos cuestiones fundamentales: por un lado, determinar el órgano jurisdiccional competente para conocer de un eventual litigio, y, por otro, precisar la Ley aplicable para resolver la controversia suscitada. En la presente investigación cabe destacar las significativas novedades que introduce el Reglamento (UE) 2016/679, de 27 de abril de 20…