Search results for "68Ga"
showing 4 items of 14 documents
Bone targeting compounds for radiotherapy and imaging: *Me(III)-DOTA conjugates of bisphosphonic acid, pamidronic acid and zoledronic acid
2016
Background Bisphosphonates have a high adsorption on calcified tissues and are commonly used in the treatment of bone disorder diseases. Conjugates of bisphosphonates with macrocyclic chelators open new possibilities in bone targeted radionuclide imaging and therapy. Subsequent to positron emission tomography (PET) examinations utilizing 68Ga-labelled analogues, endoradiotheraphy with 177Lu-labelled macrocyclic bisphosphonates may have a great potential in the treatment of painful skeletal metastases. Methods Based on the established pharmaceuticals pamidronate and zoledronate two new DOTA-α-OH-bisphosphonates, DOTAPAM and DOTAZOL(MM1.MZ) were successfully synthesized. The ligands were labe…
68 ga-dotatoc pet/ct follow up after single or hypofractionated gamma knife icon radiosurgery for meningioma patients
2021
68Ga-DOTATOC represents a useful tool in tumor contouring for radiosurgery planning. We present a case series of patients affected by meningiomas on who we performed 68Ga-DOTATOC positron emission tomography (PET)/CT pre-operatively, a subgroup of which also underwent a post-operative 68Ga-DOTATOC PET/CT to evaluate the standardized uptake value (SUV) modification after Gamma Knife ICON treatment in single or hypofractionated fractions. Twenty patients were enrolled/included in this study: ten females and ten males. The median age was 52 years (range 33–80). The median tumor diameter was 3.68 cm (range 0.12–22.26 cm), and the median pre-radiotherapy maximum SUV value was 11 (range 2.3–92). …
[177Lu]Lu-DOTA-TATE and [131I]MIBG Phenotypic Imaging-Based Therapy in Metastatic/Inoperable Pheochromocytomas and Paragangliomas: Comparative Result…
2022
PurposeThe aim of the study is to assess phenotypic imaging patterns and the response to treatment with [177Lu]Lu-DOTA-TATE and/or [131I]MIBG in paragangliomas (PGLs) and pheochromocytomas (PHEOs), globally and according to the primary location.MethodsThis is a 17-patient retrospective observational study, with 9 cases treated with [177Lu]Lu-DOTA-TATE and 8 with [131I]MIBG (37 total treatments). Functional imaging scans and treatment responses were studied in order to choose the best therapeutic option and to define the progression-free survival (PFS) and disease control rate (DCR) according to treatment modality and primary location.ResultsAll patients were studied with phenotypic nuclear …
Sterilu jaunu radioaktīvu peptīdu sintēze un to pretvēža aktivitāte in vitro sistēmās
2020
NET audzēji ir visbiežāk diagnosticētā onkoloģiskā saslimšana no visiem vēža veidiem. Krūts vēzis, kas pieskaitāms NET audzējiem, ir biežākā onkoloģiskā saslimšana sievietēm ar vairākiem simtiem tūkstošu jaunu gadījumu katru gadu. Kopš pagājušā gadsimta beigām klīniskajā praksē tiek izmantota audzēju un to metastāžu diagnostika ar radiofarmaceitiskajiem preparātiem. Pēdējos gados onkoloģijā tiek ieviesta teranostika – diagnostika un terapija ar audzējam specifisku peptīdu, kas piesaistīts pie radionuklīda. Ar HA-DOTA-TATE, kas ir somatostatīna analogs, saistīti radionuklīdi paver iespējas pacientiem pieejamai teranostikai. Taču trūkst pētījumu par HA-DOTA-TATE spēju saistīties pie SSTR. Tāp…