Search results for "6b"
showing 10 items of 66 documents
Inducible and reversible inhibition of mirna-mediated gene repression in vivo
2021
Although virtually all gene networks are predicted to be controlled by miRNAs, the contribution of this important layer of gene regulation to tissue homeostasis in adult animals remains unclear. Gain and loss-of-function experiments have provided key insights into the specific function of individual miRNAs, but effective genetic tools to study the functional consequences of global inhibition of miRNA activity in vivo are lacking. Here we report the generation and characterization of a genetically engineered mouse strain in which miRNA-mediated gene repression can be reversibly inhibited without affecting miRNA biogenesis or abundance. We demonstrate the usefulness of this strategy by invest…
Structure of eigenvectors of random regular digraphs
2018
Let $d$ and $n$ be integers satisfying $C\leq d\leq \exp(c\sqrt{\ln n})$ for some universal constants $c, C>0$, and let $z\in \mathbb{C}$. Denote by $M$ the adjacency matrix of a random $d$-regular directed graph on $n$ vertices. In this paper, we study the structure of the kernel of submatrices of $M-z\,{\rm Id}$, formed by removing a subset of rows. We show that with large probability the kernel consists of two non-intersecting types of vectors, which we call very steep and gradual with many levels. As a corollary, we show, in particular, that every eigenvector of $M$, except for constant multiples of $(1,1,\dots,1)$, possesses a weak delocalization property: its level sets have cardin…
Associazioni ‘ndranghetiste di nuovo insediamento e problemi applicativi dell’art. 416 bis c.p.
2016
Il fenomeno dell’espansione della ‘ndrangheta al di fuori della terra di origine impone alla dottrina e alla giurisprudenza di interrogarsi sulla questione della applicabilità della fattispecie di associazione di stampo mafioso alle “mafie delocalizzate” in aree geografiche non tradizionali. L’autore prende le mosse da una breve ricostruzione del modello organizzativo adottato dalla ‘ndrangheta nell’Italia settentrionale, e procede nel vagliare le possibili soluzioni al quesito se l’accertamento di una struttura organizzativa tipicamente ‘ndranghetista sia di per sé idonea ad integrare la fattispecie di cui all’art. 416bis c.p., anche in mancanza della prova di una effettiva estrinsecazione…
CCDC 251467: Experimental Crystal Structure Determination
2004
Related Article: J.R.Hanson, P.B.Hitchcock, I.Pibiri, F.Piozzi|2003|J.Chem.Res.||147|doi:10.3184/030823403103173291
CCDC 1981430: Experimental Crystal Structure Determination
2020
Related Article: Kibrom Gebreheiwot Bedane, Lukas Brieger, Carsten Strohmann, Ean-Jeong Seo, Thomas Efferth, Michael Spiteller|2020|Bioorg.Chem.|102|104102|doi:10.1016/j.bioorg.2020.104102
CCDC 647231: Experimental Crystal Structure Determination
2007
Related Article: C.Peifer, D.Schollmeyer, M.Tschertsche, S.Laufer|2007|Acta Crystallogr.,Sect.E:Struct.Rep.Online|63|o2249|doi:10.1107/S1600536807014717
CCDC 1961567: Experimental Crystal Structure Determination
2020
Related Article: Kibrom Gebreheiwot Bedane, Lukas Brieger, Carsten Strohmann, Ean-Jeong Seo, Thomas Efferth, Michael Spiteller|2020|J.Nat.Prod.|83|2122|doi:10.1021/acs.jnatprod.0c00060
CCDC 606000: Experimental Crystal Structure Determination
2006
Related Article: E.Kaasalainen, J.Tois, L.Russo, K.Rissanen, J.Helaja|2006|Tetrahedron Lett.|47|5669|doi:10.1016/j.tetlet.2006.06.014
The rank of random regular digraphs of constant degree
2018
Abstract Let d be a (large) integer. Given n ≥ 2 d , let A n be the adjacency matrix of a random directed d -regular graph on n vertices, with the uniform distribution. We show that the rank of A n is at least n − 1 with probability going to one as n grows to infinity. The proof combines the well known method of simple switchings and a recent result of the authors on delocalization of eigenvectors of A n .
The smallest singular value of a shifted $d$-regular random square matrix
2017
We derive a lower bound on the smallest singular value of a random d-regular matrix, that is, the adjacency matrix of a random d-regular directed graph. Specifically, let $$C_1<d< c n/\log ^2 n$$ and let $$\mathcal {M}_{n,d}$$ be the set of all $$n\times n$$ square matrices with 0 / 1 entries, such that each row and each column of every matrix in $$\mathcal {M}_{n,d}$$ has exactly d ones. Let M be a random matrix uniformly distributed on $$\mathcal {M}_{n,d}$$ . Then the smallest singular value $$s_{n} (M)$$ of M is greater than $$n^{-6}$$ with probability at least $$1-C_2\log ^2 d/\sqrt{d}$$ , where c, $$C_1$$ , and $$C_2$$ are absolute positive constants independent of any other parameter…