Search results for "70"

Plasma membrane redox system in the erythrocytes of rowers: Pilot study

2017

The oxidative stress results from a change in the physiological balance between oxidant and antioxidant species. This type of stress is a chemical change in the redox state of cells. The increased production of reactive species is related to an excessive metabolic activation, for example, from an intense physical exercise or an excessive caloric intake (1). In physiological conditions, muscle fibers are provided with an antioxidant system able to keep under control the excessive production of Reactive Oxygen Species (ROS).

Cruising y e-citas: un nuevo contexto para los encuentros sexuales entre hombres jóvenes que tienen sexo con hombres

2015

Resumen El objetivo de este artículo es el de explorar el papel que juega, en la actualidad, la irrupción de la mediación tecnológica de la información y la comunicación en la configuración de nuevos contextos para la relación sexual. En concreto, hemos explorado una práctica determinada, el cruising, entre hombres jóvenes que tienen sexo con hombres contactado a través de las e-citas. Se ha apostado por la metodología cualitativa con la intención de recopilar los discursos sobre sexualidad, riesgos y salud que se generan y construyen entre el grupo de iguales. Según extraemos de nuestro estudio, el nuevo marco que confiere esta tecnología estaría caracterizado por (a) una mayor accesibilid…

Epidemiology of malignant melanoma in the province of Palermo (2003-2005)

2011

<p><strong>Background</strong>: The incidence of melanoma has steadily increased worldwide and shows geographical variability according to latitude. The aim of this study was to describe the incidence of cutaneous malignant melanoma (CMM) cases in the Province of Palermo during the period 2003-2005.</p><p><strong>Methods</strong>: 231 incident cases of CMM, registered by the Cancer Registry of Palermo, were analysed. Anatomic localization, histological type, thickness, ulceration, margins, any lymph node involvement and metastases were evaluated. A statistical analysis of survival rates was performed.</p><p><strong>Results</stro…

Publicación científica biomédica: Cómo escribir y publicar un artículo de investigación Biomedical publication: how to write and publish a research a…

2011

Calibration of high voltages at the ppm level by the difference of $$^{83{\mathrm{m}}}$$ 83m Kr conversion electron lines at the KATRIN experiment

2018

The neutrino mass experiment KATRIN requires a stability of 3 ppm for the retarding potential at − 18.6 kV of the main spectrometer. To monitor the stability, two custom-made ultra-precise high-voltage dividers were developed and built in cooperation with the German national metrology institute Physikalisch-Technische Bundesanstalt (PTB). Until now, regular absolute calibration of the voltage dividers required bringing the equipment to the specialised metrology laboratory. Here we present a new method based on measuring the energy difference of two $$^{83{\mathrm{m}}}$$ 83m Kr conversion electron lines with the KATRIN setup, which was demonstrated during KATRIN’s commissioning measurements …

Parasite presence induces gene expression changes in an ant host related to immunity and longevity

2021

Most species are either parasites or exploited by parasites, making parasite&ndash

“One Ring to Bind Them All”—Part II: Identification of Promising G-Quadruplex Ligands by Screening of Cyclophane-Type Macrocycles

2010

A collection of 26 polyammonium cyclophane-type macrocycles with a large structural diversity has been screened for G-quadruplex recognition. A two-step selection procedure based on the FRET-melting assay was carried out enabling identification of macrocycles of high affinity (ΔT1/2up to30°C) and high selectivity for the human telomeric G-quadruplex. The four selected hits possess sophisticated architectures, more particularly the presence of a pendant side-arm as well as the existence of a particular topological arrangement appear to be strong determinants of quadruplex binding. These compounds are thus likely to create multiple contacts with the target that may be at the origin of their h…

The distributions of protein coding genes within chromatin domains in relation to human disease.

2019

Abstract Background Our understanding of the nuclear chromatin structure has increased hugely during the last years mainly as a consequence of the advances in chromatin conformation capture methods like Hi-C. The unprecedented resolution of genome-wide interaction maps shows functional consequences that extend the initial thought of an efficient DNA packaging mechanism: gene regulation, DNA repair, chromosomal translocations and evolutionary rearrangements seem to be only the peak of the iceberg. One key concept emerging from this research is the topologically associating domains (TADs) whose functional role in gene regulation and their association with disease is not fully untangled. Resul…

SNPs detection by eBWT positional clustering

2019

Sequencing technologies keep on turning cheaper and faster, thus putting a growing pressure for data structures designed to efficiently store raw data, and possibly perform analysis therein. In this view, there is a growing interest in alignment-free and reference-free variants calling methods that only make use of (suitably indexed) raw reads data. We develop the positional clustering theory that (i) describes how the extended Burrows–Wheeler Transform (eBWT) of a collection of reads tends to cluster together bases that cover the same genome position (ii) predicts the size of such clusters, and (iii) exhibits an elegant and precise LCP array based procedure to locate such clusters in the e…

Multiplex Amplicon Quantification (MAQ), a fast and efficient method for the simultaneous detection of copy number alterations in neuroblastoma

2010

Abstract Background Cancer genomes display characteristic patterns of chromosomal imbalances, often with diagnostic and prognostic relevance. Therefore assays for genome-wide copy number screening and simultaneous detection of copy number alterations in specific chromosomal regions are of increasing importance in the diagnostic work-up of tumors. Results We tested the performance of Multiplex Amplicon Quantification, a newly developed low-cost, closed-tube and high-throughput PCR-based technique for detection of copy number alterations in regions with prognostic relevance for neuroblastoma. Comparison with array CGH and the established Multiplex Ligation-dependent Probe Amplification method…