Search results for "70"
showing 10 items of 9933 documents
Circulating Tumor Cells (CTCs): A Unique Model of Cancer Metastases and Non-invasive Biomarkers of Therapeutic Response
2021
Late-stage cancer metastasis remains incurable in the clinic and is the major cause death in patients. Circulating tumor cells (CTCs) are thought to be metastatic precursors shed from the primary tumor or metastatic deposits and circulate in the blood. The molecular network regulating CTC survival, extravasation, and colonization in distant metastatic sites is poorly defined, largely due to challenges in isolating rare CTCs. Recent advances in CTC isolation and ex vivo culture techniques facilitates single-cell omics and the development of related animal models to study CTC-mediated metastatic progression. With these powerful tools, CTCs can potentially be used as non-invasive biomarkers pr…
Experimental evidence for a liquid-liquid crossover in deeply cooled confined water.
2014
International audience; In this work we investigate, by means of elastic neutron scattering, the pressure dependence of mean square displacements (MSD) of hydrogen atoms of deeply cooled water confined in the pores of a three-dimensional disordered SiO 2 xerogel; experiments have been performed at 250 and 210 K from atmospheric pressure to 1200 bar. The " pressure anomaly " of supercooled water (i.e., a mean square displacement increase with increasing pressure) is observed in our sample at both temperatures; however, contrary to previous simulation results and to the experimental trend observed in bulk water, the pressure effect is smaller at lower (210 K) than at higher (250 K) temperatur…
Analyse morphologique de talwegs et comportement scalant : applications des dimensions non-entières à la géographie physique
1999
Morphological talweg analysis and scaling behaviour: applying non-integer dimension to physical geography. -- The organisation of the talweg network is fundamental to the erosion system on the silty loamy plateaux of north-western France. The morphology of the Pays de Caux is a good example of successive runoff concentration caused by the nesting of small dry valleys. These are inherited from a periglacial climate and their general direction is governed by tectonics. However the detailed pattern of these forms remains complex and without obvious explanation. Non-integer dimensions may offer a ceratin logic to this relatively chaotic pattern. This paper has therefore sought to demonstrate th…
Gutters egne refleksjoner omkring hvorfor de avsluttet videregående opplæring, og hva som skal til for å fullføre utdanning : En kvalitativ studie ba…
2018
Masteroppgave psykisk helsearbeid ME504 - Universitetet i Agder 2018 Throughout our working carrier we have met youth who had dropped out from upper secondary school with that consequence that they stand without work or education. We wish to approach the phenomenon dropouts from the perspective of the youth, here boys, to try to find out more about how they think of their own possibilities. This study is part of a research project at the University of Agder and represents a contribution to the research group “Ung i Sør”. The purpose of this study is to increase understanding around how boys explain the causes behind their choice to dropout and what they express can contribute to returning t…
Aménités urbaines et périurbaines dans une aire métropolitaine de forme fractale
2002
In the THÜNEN tradition, Urban Economy is a striking abstraction, giving models that keep the main features of the wide diversity of real word cities. Nevertheless, this paradigm less suits the modern urban spatial structures (polycentrism, weak centripetal forces, etc.), particularly the peri-urban form of metropolitan areas, which are an urban/rural integrated space. In this paper, we propose a classical micro-economic urban model combined with a " SIERPINSKI's carpet " geometry, a fractal form which suits for fit together urban and rural areas in a hierarchical structure. Subject to a budget constraint, a household maximises a Cobb-Douglas/CES function, where household's taste for divers…
L'implantation des gares TGV en France: tensions interscalaires, jeux d'acteurs et recompositions spatiales
2010
L’extension du réseau de lignes à grande vitesse renouvelle le problème du positionnement des gares, notamment en France qui privilégie une logique d’efficacité fondée sur des dessertes rapides et cadencées entre grandes métropoles au détriment des espaces intermédiaires. Cette option se traduit par deux types de localisation : gare principale centrale pour les plus grandes villes et gare périphérique pour les villes petites et moyennes. Ces choix d’implantation résultent de processus interactifs qui concernent tous les niveaux de l’organisation spatiale. Ainsi, si on examine les processus de décision ayant conduit à l’implantation des gares TGV en France, ces choix et les stratégies de val…
Outlying location of logistics activities : the example of the Burgundy in France
2015
International audience; This paper contributes to the understanding of spatial location of logistics activities in an outlying region. A quantitative analysis in Burgundy (French region) underlines the important polarization of warehousing developed in a limited area during 1980–1990s intensified during 2000s. The companies that locate their warehouses in Burgundy have different strategies that could explain this outlying location. For example, the low cost of land, favorable terms of tax system and the presence of a labour pool with an important unemployed rate incentive could incentive some companies to locate their warehouses in an outlying region like the Burgundy.
Biology of the sauropod dinosaurs: the evolution of gigantism
2010
The herbivorous sauropod dinosaurs of the Jurassic and Cretaceous periods were the largest terrestrial animals ever, surpassing the largest herbivorous mammals by an order of magnitude in body mass. Several evolutionary lineages among Sauropoda produced giants with body masses in excess of 50 metric tonnes by conservative estimates. With body mass increase driven by the selective advantages of large body size, animal lineages will increase in body size until they reach the limit determined by the interplay of bauplan, biology, and resource availability. There is no evidence, however, that resource availability and global physicochemical parameters were different enough in the Mesozoic to ha…
Correlation Between Smoking Paradox and Heart Rhythm Outcomes in Patients With Coronary Artery Disease Receiving Percutaneous Coronary Intervention
2022
BackgroundThe effect of smoking on short-term outcomes among patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) is controversial. However, little is known about the impact of smoking on long-term outcomes in patients with stable coronary artery disease (CAD) who receive PCI.MethodsA total of 2,044 patients with stable CAD undergoing PCI were evaluated. They were divided into two groups according to smoking status (current smokers vs. non-smokers). Baseline characteristics, exposed risk factors, angiographic findings, and interventional strategies were assessed to compare the long-term clinical outcomes between groups. Predictors for myocardial in…