Search results for "71"

Experimental Research on the Cutting of Metal Materials by Electrical Discharge Machining with Contact Breaking with Metal Band as Transfer Object

2020

The scientific paper presents practical research carried out by a mixed team of Romanian researchers from universities and the business environment. The research consists in applying the process of cutting metallic materials through electrical discharge machining with contact breaking using a metal band as a transfer object. The research was implemented with the help of a specially designed installation in the laboratory and subsequently all the necessary steps were taken to obtain the patent for it. Various metallic materials were cut using this process, but first of all, high alloy steels. In the global research conducted by the authors, active experimental programs and classic experiment…

DESDEO: The Modular and Open Source Framework for Interactive Multiobjective Optimization

2021

Interactive multiobjective optimization methods incorporate preferences from a human decision maker in the optimization process iteratively. This allows the decision maker to focus on a subset of solutions, learn about the underlying trade-offs among the conflicting objective functions in the problem and adjust preferences during the solution process. Incorporating preference information allows computing only solutions that are interesting to the decision maker, decreasing computation time significantly. Thus, interactive methods have many strengths making them viable for various applications. However, there is a lack of existing software frameworks to apply and experiment with interactive …

El ?Alivio de las Indias?. la Real Hacienda Filipina, 1565-1800

2019

Previo al estudio de la Real Hacienda filipina, el trabajo se centrará en la definición del marco territorial, la función del archipiélago en la estrategia imperial y la gran transformación de finales del siglo xVIII que afectó a su situación en el conjunto colonial. En segundo lugar, se expondrá el estado de la cuestión y las principales hipótesis sobre la evolución del Tesoro filipino y los problemas que planteaba su viabilidad, así como las fuentes y la metodología empleadas. A continuación se examinarán las grandes tendencias de la Hacienda en el largo plazo y los componentes del ingreso y el gasto, para finalizar con algunas conclusiones, en especial la respuesta a la siguiente pregunt…

Analysis of Possibility of Yeast Production Increase at Maintained Carbon Dioxide Emission Level

2016

Abstract Main parameters polluting of technological wastewater (dregs from decantation and thicken of the wort) from yeast industry are: nitrogen, potassium and COD. Such wastewater are utilized mostly on agricultural fields. Unfortunately, these fields can only accept a limited amount of wastes. The basic parameter limiting there the amount of wastewater is nitrogen. When capacity of the production is large sewages are often pretreated at an evaporator station. However, due to the fairly high running costs of the evaporator station currently such a solution is applied only to a small amount of wastes (just to meet legal requirements). Replacement of the earth gas with a biomass being suppl…

Cine y música: : sobre la consubstancialidad de las artes y el diálogo

2013

Jaume Vicent: un escultor singular en la encrucijada de dos siglos

2019

Afinidades entre la arquitectura y la música. Algunas reflexiones

2019

Aportación hispánica a la historia de la guitarra española hasta la publicación de las reglas de Pablo Minguet en 1754

2019

Exposure to a Highly Caloric Palatable Diet During Pregestational and Gestational Periods Affects Hypothalamic and Hippocampal Endocannabinoid Levels…

2016

Journal Article; Exposure to unbalanced diets during pre-gestational and gestational periods may result in long-term alterations in metabolism and behavior. The contribution of the endocannabinoid system to these long-term adaptive responses is unknown. In the present study, we investigated the impact of female rat exposure to a hypercaloric-hypoproteic palatable diet during pre-gestational, gestational and lactational periods on the development of male offspring. In addition, the hypothalamic and hippocampal endocannabinoid contents at birth and the behavioral performance in adulthood were investigated. Exposure to a palatable diet resulted in low weight offspring who exhibited low hypotha…

LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State.

2017

The low-density lipoprotein receptor-related protein 1, LRP1, interacts with APP and affects its processing. This is assumed to be mostly caused by the impact of LRP1 on APP endocytosis. More recently, also an interaction of APP and LRP1 early in the secretory pathway was reported whereat retention of LRP1 in the ER leads to decreased APP cell surface levels and in turn, to reduced Aβ secretion. Here, we extended the biochemical and immunocytochemical analyses by showing via live cell imaging analyses in primary neurons that LRP1 and APP are transported only partly in common (one third) but to a higher degree in distinct fast axonal transport vesicles. Interestingly, co-expression of LRP1 a…