Search results for "7210*"
showing 10 items of 20 documents
Enrichissement sémantique d'un IFC pour une extraction partielle dynamique
2014
http://www.lcdpu.fr/livre/?GCOI=27000100860820&fa=sommaire; International audience; La dématérialisation de l'ensemble des données et des processus dans le domaine du bâtiment est un enjeu mondial depuis ces 10 dernières années. Au-delà de la simple représentation géométrique d'un bâtiment, le BIM s'impose petit à petit comme un système d'information coopératif complexe, intégrant avec difficulté les données et pratiques hétérogènes des différents acteurs du domaine. La restitution intégrée de ces données aux usagers du bâtiment est une opération délicate. Pour répondre à ce verrou, nous utilisons une approche sémantique de représentation du bâtiment et particulièrement de la norme IFC. Cet…
Review: monoclinic zirconia, its surface sites and their interaction with carbon monoxide
2015
This review concerns monoclinic zirconia, its surface sites and their probing with carbon monoxide. The surface sites and their modifications using thermal treatments with vacuum or reactive gases are also included. In this work, we present information on the nature and manipulation of hydroxyl species and their quantities on the surface, the different types of cationic sites where CO is adsorbed linearly and their energetics, as well as the surface sites and dynamics of formate formation. We also compare the surface concentrations of the different surface species to better understand the extent and nature of the interactions. Finally, we discuss some of the remaining open questions and how…
Knockout of myeloid cell leukemia-1 induces liver damage and increases apoptosis susceptibility of murine hepatocytes
2008
Apoptosis, or programmed cell death, regulates tissue development and homeostasis in multi-cellular organisms. Extrinsic or intrinsic death signals activate pro-apoptotic pathways, resulting in the activation of caspases and finally in cell death. An important event during apoptosis process is the permeabilization of the outer mitochondrial membrane (OMM). Integrity of the OMM is regulated by the Bcl-2 protein family, which is divided into three groups: anti-apoptotic members Bcl-2, Bcl-xL and myeloid cell leukemia-1 (Mcl-1), pro-apoptotic multidomain members Bax and Bak, and pro-apoptotic BH3-only proteins. Mitochondrial activation is regulated by selective interactions of Bcl-2 proteins v…
Hepatocyte-specific deletion of the antiapoptotic protein myeloid cell leukemia-1 triggers proliferation and hepatocarcinogenesis in mice
2010
Regulation of hepatocellular apoptosis is crucial for liver homeostasis. Increased sensitivity of hepatocytes toward apoptosis results in chronic liver injury, whereas apoptosis resistance is linked to hepatocarcinogenesis and nonresponsiveness to therapy-induced cell death. Recently, we have demonstrated an essential role of the antiapoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) in hepatocyte survival. In mice lacking Mcl-1 specifically in hepatocytes (Mcl-1Δhep), spontaneous apoptosis caused severe liver damage. Here, we demonstrate that chronically increased apoptosis of hepatocytes coincides with strong hepatocyte proliferation resulting in hepatocellular carcinoma (HCC).…
Projekt komputu armii litewskiej z 1703 r. wraz z podziałem na poszczególne chorągwie i regimenty
2017
W niniejszym artykule zostaje wprowadzone do obiegu naukowego nowe źródło do badań nad historią armii litewskiej w okresie wielkiej wojny północnej (1700–1721), którym jest projekt komputu z 1703 r. Znajduje się on w Bibliotece Kórnickiej Polskiej Akademii Nauk w rękopisie o sygnaturze 985. W inwentarzu rękopisów biblioteki widnieje natomiast jako komput z 1706 r. Trudno jednak ustalić faktyczną datę jego powstania. Możliwe jest jedynie oszacowanie pewnych cezur. Sporządzony został na pewno przed 27 listopada 1703 r. (wprowadzenie w życie postanowień rady senatu w Jaworowie o pozbawieniu urzędów Sapiehów). Natomiast prawdopodobnie powstał przed lub w trakcie sejmu lubelskiego (11 czerwca – …
Anti-inflammatory Function of High-Density Lipoproteins via Autophagy of IκB Kinase
2015
Background & Aims: Plasma levels of high-density lipoprotein (HDL) cholesterol are frequently found decreased in patients with inflammatory bowel disease (IBD). Therefore, and because HDL exerts anti-inflammatory activities, we investigated whether HDL and its major protein component apolipoprotein A-I (apoA-I) modulate mucosal inflammatory responses in vitro and in vivo. Methods: The human intestinal epithelial cell line T84 was used as the in vitro model for measuring the effects of HDL on the expression and secretion of tumor necrosis factor (TNF), interleukin-8 (IL-8), and intracellular adhesion molecule (ICAM). Nuclear factor-κB (NF-κB)-responsive promoter activity was studied by …
L'anonymat du donneur de gamètes face au droit d'accès aux archives
2016
International audience; En l’espèce, le Conseil d’État apprécie si le refus de communiquer des informations et documents concernant un donneur de gamètes porte atteinte au droit d’accès aux archives invoqué par la personne conçue grâce à ce don. Le juge considère que le refus, fondé sur le respect du principe d’anonymat, ne fait pas obstacle à son droit d’accès dans la mesure où le délai de communicabilité n’a pas expiré.
Supposition d’enfant et structure de substitution dans l’histoire de Silvie : les « phantomes de la supposition » dans les Illustres Françaises
2016
International audience
Strappazzandola di parole ... maltrarrandola apiù un posso... Una lite tra fratello e sorella nella Sicilia di fine seicento
2019
La sfera domestica, nel passato come nel presente, è ?l?ambito privilegiato di espressione e di azione della violenza maschile contro le donne?. Nell?ultimo quarantennio gli studi su questo fenomeno di lunga durata e rappresentativo delle relazioni tra uomini e donne si sono moltiplicati. La violenza contro le donne si è rivelata un angolo visuale molto importante per riflettere su ?alcuni temi centrali nella storia europea: la famiglia, il potere, la civilizzazione? ed è oggetto di studio in diversi ambiti disciplinari, incluso quello storico. In questo articolo ho preso in esame la lunga contesa giudiziaria tra Anna Ruffo e il fratello maggiore Placido Ruffo, principe della Scaletta, prim…
Machine Perfusions in Liver Transplantation: The Evidence‐Based Position Paper of the Italian Society of Organ and Tissue Transplantation
2020
The use of machine perfusion (MP) in liver transplantation (LT) is spreading worldwide. However, its efficacy has not been demonstrated, and its proper clinical use has far to go to be widely implemented. The Società Italiana Trapianti d’Organo (SITO) promoted the development of an evidence-based position paper. A 3-step approach has been adopted to develop this position paper. First, SITO appointed a chair and a cochair who then assembled a working group with specific experience of MP in LT. The Guideline Development Group framed the clinical questions into a patient, intervention, control, and outcome (PICO) format, extracted and analyzed the available literature, ranked the quality of th…