Search results for "7"
showing 10 items of 46876 documents
The CANNA-TICS Study Protocol: A Randomized Multi-Center Double-Blind Placebo Controlled Trial to Demonstrate the Efficacy and Safety of Nabiximols i…
2020
Background: Gilles de la Tourette syndrome (TS) is a chronic neuropsychiatric disorder characterized by motor and vocal tics. First-line treatments for tics are antipsychotics and tic-specific behavioral therapies. However, due to a lack of trained therapists and adverse events of antipsychotic medication many patients seek alternative treatment options including cannabis. Based on the favorable results obtained from case studies on different cannabis-based medicines as well as two small randomized controlled trials using delta-9-tetrahydrocannabinol (THC), we hypothesize that the cannabis extract nabiximols can be regarded as a promising new and safe treatment strategy in TS.Objective: To …
Open Service Innovation: The Case of Tourism Firms in Scandinavia
2016
Most empirical research investigating open innovation has focused on the development of new physical products in manufacturing industries, whereas open service innovation has not been researched correspondingly. Services have some characteristics that distinguish them from physical products, which may affect the types of open innovation practice utilised during service innovation processes. Tourism services comprise a subset of services that is particularly distant from tangible products. Therefore, the exploration of how tourism firms utilise different types of open innovation practice offers a valuable opportunity to learn about the nature of open service innovation practices. Thus, this …
The promotion of tourism in Italian regions from a sensorial perspective: a website content analysis
2022
Recent tourism literature has identified the sensory dimension as key to understanding, planning and marketing tourist experiences. This paper aims to understand to what extent Italian regions consider the sensorial perspective in tourist communication, focusing the analysis on their institutional websites. We used the content analysis method considering two different periods to investigate the evolution of Italian tourism promotion. The results show that for all institutional websites, over time, attention engages only some of the five sensorial dimensions. That is, the communication does not appear balanced. Furthermore, the promotional communication in several regions is more oriented to…
Siracusa e la Sicilia nel III secolo a.C.: problemi conoscitivi e proposte di lettura dei fenomeni urbanistici e architettonici
2017
L’evoluzione sotto il profilo urbanistico e architettonico delle città di Sicilia nel III secolo a.C. può essere compresa solo a partire da un esame delle evidenze di Siracusa, la maggiore città dell’Occidente greco-ellenistico e capitale di un regno che sotto Agatocle e soprattutto sotto Ierone II vede un prodigioso sviluppo non solo per l’estensione dell’area urbana, ma soprattutto per la riconfigurazione dello spazio cittadino in forme innovative, destinate a influenzare in maniera decisiva anche le città minori del regno e dell’Oriente dell’isola, e successivamente anche dei comprensori centro-occidentali e settentrionali. L’aspetto più importante e programmatico nella rimodulazione del…
Valor de la citometría de flujo Multiparamétrica en una estrategia basada en la toxicología in vitro para la predicción de Riesgo y clasificación de …
2015
La entrada en vigor de las Normativas REACH (PARLAMENTO EUROPEO 2006) y CLP (PARLAMENTO EUROPEO 2008) fomentó que la Unión Europea financiara diferentes programas marco para desarrollar estrategias in vitro para evaluar la seguridad de los productos químicos y reducir el número de animales y el coste económico. Nuestro estudio desarrolla una estrategia citómica in vitro utilizando la citometría de flujo (CMF) (Herrera et al. 2007) para la predicción de riesgo y clasificación de 57 compuestos químicos.El objetivo último de esta tesis es el de proporcionar métodos citómicos, como alternativa in vitro al animal de laboratorio para mejorar el valor predictivo de los ensayos de citotoxicidad bas…
Cultura Digital y Nuevos Perfiles Profesionales: desafíos regionales
2010
Este trabajo propone una revisión de las nuevas tendencias en el mundo del trabajo, su orientación hacia los servicios, la gestión del conocimiento y el uso de las nuevas tecnologías. Bajo este marco se analizan algunos de los desafíos que debe enfrentar la educación actual y propone un marco de análisis en relación a aquellas competencias y habilidades que contribuirían a formar a un trabajador e-competente, adaptable y en permanente aprendizaje.
Restituir el poder, desarrollar la autonomia: trabajo social, responsabilidad local y participación comunitaria en un proyecto de promoción humana en…
2016
El desarrollo es un proceso desequilibrado, en el que operan tensiones, estímulos, contradicciones sectoriales y factores endógenos, peculiares de una única realidad, los cuales requieren en cada proyecto de cooperación un significativo compromiso de conocimiento y de comprensión del rol que juegan los factores de incertidumbre, los vínculos y los factores colaterales de cada elemento significativo (social, cultural, económico, político, etc.). Lo anterior requiere, en primer lugar prever la constante lectura, sin prejuicios, de las necesidades y de las prioridades de los beneficiarios mediante enfoques participativos, junto a una evaluación de los proyectos de desarrollo que no se encomien…
Phase equilibria of Pantelleria trachytes (Italy): constraints on pre-eruptive conditions and on the metaluminous to peralkaline transition in silici…
2018
Pantelleria Island is the type locality of pantellerite, an iron and alkali-rich rhyolite (P.I=molar Na2O+K2O/Al2O3 >1.05). Peralkaline rhyolites (i.e pantellerite and comendite) and trachytes usually represent the felsic end-members in continental rift systems (e.g., Pantelleria, Tibesti, Ethiopia, Afar, Kenya, Bain and Range, South Greenland) and in oceanic sland settings (Socorro Is., Easter Is., Iceland and Azores). The origin of peralkaline rhyolites in the different tectonic settings is still a matter of debate and three hypotheses have been suggested: (a) crystal fractionation of alkali-basalt in a shallow reservoir to produce a trachyte which subsequently gives rise to a pantelle…
Il problema della definizione della "illiceità"della mediazione nel nuovo reato di traffico di influenze illecite
2022
Le modifiche apportate al delitto di traffico d’influenze illecite ad opera della legge n. 3/2019 hanno accentuato il deficit di determinatezza che già caratterizzava la fattispecie sin dalla sua introduzione, delineando un modello di incriminazione incapace di selezionare le condotte di intermediazione penalmente rilevanti distinguendole dalla attività di lobbying consentita. Il lavoro analizza la specifica questione dell’interpretazione del predicato di “illiceità” della mediazione esaminando le diverse tesi proposte in dottrina e in giurisprudenza. Conclusivamente, l’Autore ritiene che l’interpretazione restrittiva dell’art. 346-bis c.p., che inquadra la fattispecie come delitto “avampos…
A New Perspective on the Relationship between Trading Variables and Volatility in Futures Markets
2017
In this paper, we study the relationship between trading-related variables and volatility in futures markets, from a new unifying perspective, which is based on the separation of open and closed positions. Volatility in stock index futures markets (Standard & Poor’s 500, DAX 30 and Nikkei 225) is related to the flow of contracts entered into the markets and the flow of contracts that are closed out. In general, the daily changes in the number of open and closed positions are both positively correlated with volatility. Additionally, there is a stronger positive relationship between the number of open (respectively, closed) positions and contemporaneous volatility on those days when t…