Search results for "7"
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Korruptio ja huono hallinto tutkimuskohteena varhaismodernissa Ruotsissa : näkökulmat, menetelmät ja mahdollisuudet
2021
Artikkelissa käsitellään korruption ja huonon hallinnon tutkimusta menneisyydessä, ennen kaikkea Ruotsin ja Suomen yhteisen historian ajalla. Tarkoituksena on antaa tämänhetkisen tutkimustiedon valossa yleiskuva siitä, mitä teemasta tällä hetkellä tiedetään sekä pohtia tulevan tutkimuksen mahdollisuuksia, ongelmia (mukaan luettuna lähdekriittiset vaikeudet) sekä vastaisen tutkimuksen lähestymistapoja.
Övervakning av försummelse och korruption i häradshövdingars tjänsteutövning i Viborgs guvernement 1750-1780-talen
2022
Advokatfiskalerna vid hovrätterna i Finland fram till 1900 : utbildning, karriär och social status
2022
Applying Axial Symmetries to Historical Silk Fabrics: SILKNOW’s Virtual Loom
2020
Symmetry is part of textile art in patterns and motifs that decorate fabrics, which are made by the interlacement of warp and wefts. Moreover, the 3D representation of fabrics have already been studied by some authors
Purification and crystallization of the two major coat proteins of bacteriophage P23-77 for x-ray crystallography
2009
An ancient virus type from extreme environments
2014
Vaginal infection of mice with HSV type 2 variant ER−: A new animal model for human primary genital HSV type 2 infections
1992
Abstract Studying the pathogenesis of vaginal infections in mice with two variants of Herpes simplex virus type 2 (HSV-2) strain ER we observed that both variants ER+ and ER− caused severe vaginitis but only ER+ invaded the CNS leading to lethal neurological disease. In contrast, mice infected with ER− cleared the virus from the vagina and recovered from infection. ER+ and ER− expressed equal levels of thymidine kinase (TK) indicating a TK-independent difference in neurovirulence. Using the non-neurovirulent variant ER−, we were able to investigate humoral immune responses late after infection. Vaginal infection with ER− suppressed serum antibody formation after a secondary systemic HSV-1 i…
CVB3 VP1 interacts with MAT1 to inhibit cell proliferation by interfering with Cdk-activating kinase complex activity in CVB3-induced acute pancreati…
2021
Coxsackievirus B3 (CVB3) belongs to the genus Enterovirus of the family Picornaviridae and can cause acute acinar pancreatitis in adults. However, the molecular mechanisms of pathogenesis underlying CVB3-induced acute pancreatitis have remained unclear. In this study, we discovered that CVB3 capsid protein VP1 inhibited pancreatic cell proliferation and exerted strong cytopathic effects on HPAC cells. Through yeast two-hybrid, co-immunoprecipitation, and confocal microscopy, we show that Menage a trois 1 (MAT1), a subunit of the Cdk-Activating Kinase (CAK) complex involved in cell proliferation and transcription, is a novel interaction protein with CVB3 VP1. Moreover, CVB3 VP1 inhibited MAT…
Internalization of novel non-viral vector TAT-streptavidin into human cells
2007
BMC Biotechnology, 7 (1)
Infection-induced chromatin modifications facilitate translocation of herpes simplex virus capsids to the inner nuclear membrane
2021
Herpes simplex virus capsids are assembled and packaged in the nucleus and move by diffusion through the nucleoplasm to the nuclear envelope for egress. Analyzing their motion provides conclusions not only on capsid transport but also on the properties of the nuclear environment during infection. We utilized live-cell imaging and single-particle tracking to characterize capsid motion relative to the host chromatin. The data indicate that as the chromatin was marginalized toward the nuclear envelope it presented a restrictive barrier to the capsids. However, later in infection this barrier became more permissive and the probability of capsids to enter the chromatin increased. Thus, although …