Search results for "7α"
showing 3 items of 3 documents
EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells
2017
Arrival of encephalitogenic T cells at inflammatory foci represents a critical step in development of experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis. EBI2 and its ligand, 7{alpha},25-OHC, direct immune cell localization in secondary lymphoid organs. CH25H and CYP7B1 hydroxylate cholesterol to 7{alpha},25-OHC. During EAE, we found increased expression of CH25H by microglia and CYP7B1 by CNS-infiltrating immune cells elevating the ligand concentration in the CNS. Two critical pro-inflammatory cytokines, interleukin-23 (IL-23) and interleukin-1 beta (IL-1{beta}), maintained expression of EBI2 in differentiating Th17 cells. In line with this, EBI2 enhan…
Androgēnie anaboliskie steroīdi, to ietekme uz veselību un izplatība sabiedrības vidū
2016
Ārējais izskats spēj ietekmēt apkārtējo sabiedrības viedokli, veidojot priekšstatu par cilvēka raksturu un spējām. Izsenis cilvēkus ieinteresējis, kā izmantojot mazāku piepūli iegūt pievilcīgāku ķermeņa izskatu un labāku sportisko sniegumu. Lai sasniegtu mērķi cilvēki dažkārt ir gatavi izmēģināt visdažādākos līdzekļus, lai gan tiem ir risks pasliktināt veselību un izraisīt nopietnas blakusparādības. Šī darba mērķis bija noskaidrot, vai Latvijā ir izplatīta androgēno anabolisko steroīdu lietošana, kādi ir to lietošanas paradumi un, kurš no testosterona līdzekļiem BENU aptieku tīklā ir vispieprasītākais laika posmā no 2013. gada 1. janvāra līdz 2015. gada 31. decembrim. Pēc iegūtajiem aptauju…
Age-related changes in cholesterol metabolism in macrosomic offspring of rats with streptozotocin-induced diabetes.
2001
The aim of this study was to determine the impact of diabetic macrosomia on cholesterol and lipoprotein metabolism. Age-related changes in the activities of serum LCAT, hepatic HMG-CoA reductase, cholesterol 7α-hydroxylase, and ACAT, the major enzymes involved in cholesterol metabolism, were determined in macrosomic offspring of streptozotocin-induced diabetic rats. Hepatic, serum, and lipoprotein cholesterol contents were also examined. Mild hyperglycemia in pregnant rats was induced by intraperitoneal injection of streptozotocin (40 mg/kg body weight) on day 5 of gestation. Control pregnant rats were injected with citrate buffer. At birth, macrosomic pups had higher serum, LDL-HDL1, and H…